日本“自身癌疫苗”用于临床实验

近来 ,日本细胞医药公司和日本物理化学研究所合作 ,用患者自身的癌细胞制作疫苗 ,以提高患者免疫机能治疗癌症 ,在日本引起广泛关注。据《日经产业新闻》日前报道 ,所谓“自身癌疫苗”是从患者通过手术切除的病变部分提取 2克癌细胞组织 ,用福尔马林使其失去活性 ,不再具有癌变功能。然后给这些组织施以特殊药剂制成疫苗注入患者体内。这样 ,失去活性的癌细胞就可以提高免疫机能利用患者自身的癌细胞制作疫苗并用于临床研究还是第一次。日本细胞医药公司计划今后把它作为一种新的癌症治疗方法加以普及和推广。日本细胞医药公司的“自身癌疫…     

人类“抗癌战争“新动向

虽然医药科学不断地发明了许多新方法来对付癌症这一凶险杀手,美国的癌症年度报告却称死亡率的下降停止了——     

治愈植物癌症枯黄萎病的研究

本文论述了植物癌症——枯萎病和黄萎病的的发生发展史、发病症状、致病原因和致病机理以及世界范围内防治这两种病的研究历史和现状;重点论述了绿色药肥"特效灭萎灵"治愈植物癌症的理论依据、特点和优点;指出了这一重大发明的理论意义和实践意义,它的开发推广不但对中国农业,而且对世界农业都有着不可估量的作用。     

陕西师范大学侯颖春教授

侯颖春,男,1959年生,陕西眉县人,医学博士、博士后（美国国立卫生研究院）,陕西师范大学分子细胞生物学教授、博士生导师,＂国家科学技术奖＂和＂教育部科学技术奖＂评审专家,陕西省基因组与健康学会副理事长,陕西省细胞生物学学会理事,美国生物化学与分子生物学学会（ASBMB）会员,美国微生物学学会（ASM）会员。     

Mechanisms of inherited cancer susceptibility

A small proportion of many cancers are due to inherited mutations in genes, which result in a high risk to the individual of developing specific cancers. There are several classes of genes that may be involved： tumour suppressor genes, oncogenes, genes encoding proteins involved in DNA repair and cell cycle control, and genes involved in stimulating the angiogenic pathway. Alterations in susceptibility to cancer may also be due to variations in genes involved in carcinogen metabolism. This review discusses examples of some of these genes and the associated clinical conditions caused by the inheritance of mutations in such genes.     

A data-mining approach to biomarker identification from protein profiles using discrete stationary wavelet transform

Objective： To develop a new bioinformatic tool based on a data-mining approach for extraction of the most informative proteins that could be used to find the potential biomarkers for the detection of cancer. Methods： Two independent datasets from serum samples of 253 ovarian cancer and 167 breast cancer patients were used. The samples were examined by surfaceenhanced laser desorption/ionization time-of-flight mass spectrometry （SELDI-TOF MS）. The datasets were used to extract the informative proteins using a data-mining method in the discrete stationary wavelet transform domain. As a dimensionality reduction procedure, the hard thresholding method was applied to reduce the number of wavelet coefficients. Also, a distance measure was used to select the most discriminative coefficients. To find the potential biomarkers using the selected wavelet coefficients, we applied the inverse discrete stationary wavelet transform combined with a two-sided t-test. Results： From the ovarian cancer dataset, a set of five proteins were detected as potential biomarkers that could be used to identify the cancer patients from the healthy cases with accuracy, sensitivity, and specificity of 100%. Also, from the breast cancer dataset, a set of eight proteins were found as the potential biomarkers that could separate the healthy cases from the cancer patients with accuracy of 98.26%, sensitivity of 100%, and specificity of 95.6%. Conclusion： The results have shown that the new bioinformatic tool can be used in combination with the high-throughput proteomic data such as SELDI-TOF MS to find the potential biomarkers with high discriminative power.     

癌症的研究策略与方法

癌症是一种严重威胁人类生命与健康的恶性疾病.目前还没有找到有效的方法来治愈癌症.从癌症的发现、治疗及预防史对癌症的产生原因、研究进程和治疗方法等进行综述,并提出了癌细胞很可能是高等动物细胞回复突变成"原始真核动物细胞"的理论.治疗癌症必须找出癌细胞与正常细胞在代谢、生长、繁殖及调控上的差异,从生命机理上理解癌症,从而达到根治的目的.     

线粒体去乙酰化酶SIRT3与衰老疾病

线粒体去乙酰化酶SIRT3是酵母Sir2同源蛋白,通过对线粒体多种蛋白质赖氨酸的去乙酰化修饰,它可以调控多种代谢过程,如脂肪酸的β-氧化作用、TCA循环、氧化磷酸化等.SIRT3可参与氧化应激反应,降低细胞内ROS水平;也可以作为一种肿瘤抑制因子,促进细胞的凋亡.在某些乳腺癌细胞中,SIRT3表达下调.敲除SIRT3或者SIRT3表达降低,可影响与代谢相关的衰老性疾病如心脏疾病、癌症等的发生.论文总结了近年去乙酰化酶SIRT3在代谢调控及癌症细胞凋亡中的分子机制以及SIRT3与心脏疾病、癌症的相互关系,希望为衰老疾病的预防和治疗提供一定的理论基础.     

南京癌友康复协会成员的基本分析

对南京癌友康复协会１０１１名会员所患恶性肿瘤（下简称癌症）部位、性别、患病年龄、生存时间、职业和治疗康复方法,以及对１８名死亡会员作了统计分析,显示出该协会成员的基本状况,在一定程度上反映了南京地区癌症患者的特征