磁感应治疗研究和临床试验

 肿瘤磁感应加温治疗是近年来兴起的一项新型肿瘤治疗技术。该技术利用定位导入肿瘤靶区的磁性介质在交变磁场下的磁化损耗产热,对恶性肿瘤实施磁介导加温治疗。研究表明,肿瘤组织在交变磁场诱导的磁热效应下升温至40～70℃时,靶区沉积的热能作用可特异性杀死癌细胞,抑制癌症复发和转移,并可激发机体的抗癌免疫效应,进一步增强治疗效果,是一种简便易行、安全有效的肿瘤治疗方法。磁感应加温治疗在肿瘤治疗的特异性、靶向性等方面显现出其独特优势,已引起了国内外肿瘤临床治疗界的极大兴趣。本文对实验室近年来开展的基于多种磁性介质的肿瘤磁感应热疗研究进行了综述,主要包括磁感应治疗设备研制、热疗用磁性介质研发和磁热疗生物医学实验研究3个方面。在这些研究的基础上,肿瘤磁感应热疗的临床前实验已经完成,目前已经开展一期临床试验研究。     

磁感应热疗联合125I籽源近距离放疗研究

 磁感应热疗植入合金热籽与放射籽源在尺度上处于同一水平,当热籽和放射籽源同时植入肿瘤组织,热场和辐射将共同作用于肿瘤细胞,提高肿瘤细胞的杀灭作用.本文应用电磁学理论计算射频磁场中热籽和放射籽源的产热功率.并将不同分布的热籽和放射籽源置于磁感应设备射频磁场中,调节磁场参数,观察不同条件下的温升曲线.同时研究了放射籽源在磁感应射频磁场下的升温情况以验证放射籽源的安全性,以及合金热籽与放射籽源混合排布情况下的升温情况以验证联合治疗的有效性.理论计算和实验结果表明,放射籽源在磁感应治疗射频磁场下(50~500kHz)磁热效应不显著,其用于热放疗的安全性得到验证.将放射籽源与热籽混合植入琼脂体模和离体肌肉组织,在介质植入区域内温度均远超过43℃,可实现植入区域内热疗对放疗的增敏作用.     

肿瘤治疗的绿色疗法——热疗

 热疗是一门古老的科学.古希腊著名医生希波克拉底即认为:“药物不能治的可用手术治,手术不能治的可用热来治疗,热不能治的就无法治了.”这在一定程度上预言了热疗在肿瘤治疗中的重要作用.     

三峡茶疗探源

茶疗是中医与茶文化结合的产物，茶疗是一种普遍现象，又具有源远流长的历史。关于三峡茶疗起源，有各种不同的解说，普疗说、特疗说、种疗说相辅相成，相互印证，反映了该地区茶疗文化的博大深厚。     

一种肿瘤热疗温度控制系统

一种以凌阳SPCE061A单片机为核心构成的肿瘤热疗温度控制系统。在控制系统中,运用传统模糊的控制方法,实验表示稳定质量不好,并且稳定精确度不高。而在基本模糊控制器的方法上,将插值计算结合到模糊判决过程中,不但简化了模糊控制表的设计,而且具有动态响应好、超调小,稳态品质较高,无静差以及鲁棒性较强等特点。     

提高青贮饲料品质的方法

1．加酸青贮法。青贮原料中加入一定量无机酸或缓冲液,能迅速降低pH值,促进青贮料迅速下沉,正常发酵,从而达到长期保存的目的。具体方法：取30％盐酸92份和40％硫酸8份混合,使用时每100份此种混合液加入400份水予以稀释,每1000公斤原料加此稀释液50-60公斤。     

Development and application of tumor-targeting magnetic nanoparticles FA-StNP@Fe2O3 for hyperthermia

Modified magnetic starch nanoparticles （FA-StNP@Fe2O3） were synthesized by conjugating folic acid （FA-PEG-NH2） onto the surface of magnetic starch nanoparticles （StNP@Fe2O3） prepared by reverse microemulsion method. The synthesized FA-StNP@Fe2O3 was investigated by transmission electron microscopy and zeta potential analysis. The average size of its well dispersed particles was 250 nm. The iron concentration of 2 mg/g was detected by phenanthroline method. Placing FA-StNP@Fe2O3 nanoparticles in the alternating magnetic field for 30 min resulted in an increase in the suspension temperature from ambient temperature （37℃） to a value between 42℃ and 43℃. Co-cultured nanoparticles and Hela cell line or normal HUEC-12 cell line, and the biological effects at the cellular level were investigated in the alternating magnetic field using MTT assay, Hochest-PI double staining and flow cytometry analysis. Experimental results showed that FA-StNP@Fe2O3 within acertain concentration range has no obvious effect on cell proliferation. When treated in the magnetic field, apoptosis rate on Hela induced by FA-StNP@Fe2O3 was 13.4%. Prussian blue staining analysis confirmed that the nanoparticles modified with folic acid had improved ability in tumor cell-targeting, and therefore, potential applications in biomedical and magnetocaloric areas. It is expected be applied in tumor targeting therapy in the near future.     

Hyperthermia by a nitinol stent in an alternating magnetic field:Safety and feasibility in rabbit esophageal cancer

Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer.This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field (AMF) and investigated whether this method offers a therapeutic option for esophageal cancer.Nitinol stents were placed in the cervical esophagi of healthy rabbits,which were heated in an AMF for different times at 43,46 and 50 ℃.The esophagi were histologically examined after a week to observe whether there was transmural necroses.Then esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46℃ for 10 min.Stents were heated to a target temperature within 5 min.The highest tolerated temperature and time for the healthy rabbit esophagus was at 46℃ for 10 min.Tumor growth was delayed by heating and it was statistically significant.Heating the rabbit esophageal wall at 46℃ for 10 min proves to be safe and effective in delaying tumor growth.     

艾条灸治疗带状疱疹后遗神经痛的疗效观察

目的 观察用艾条灸治疗带状疱疹后遗神经痛的疗效.方法 将86例带状疱疹后遗神经痛的患者,随机分成两组,治疗组46例.应用艾条对病变部进行灸疗.对照组40例,选用维生素B1、维生素B12神经营养剂,口服消炎痛等常规疗法.分析两组疗效有无差别.结果 治疗组总有效率88.13％,对照组总有效率为65％,两组比较差异有显著性(P<0.05).结论 艾条灸治疗带状疱疹后遗神经痛,疗效显著值得推广.