Suppressing progress of pancreatitis through selective inhibition of NF-κB activation by using NAC

OBJECTIVE: To explore the characteristics of NF-KappaB activation in the progress of pancreatitis, the relationship with expression of TNF-alpha in the inflammatory reaction, and prevent the exacerbation of pancreatitis by using NAC. METHOD: Forty-eight rats were divided into three groups: therapy (group C), pancreatitis (group B) and control (group A). NAC served as the inhibitor of NF-KappaB activation. In the time intervals of 1.5, 3.0, 6.0, 12.0 hour, NF-KappaB activation was detected with flow cytometry (FCM) and the expression of TNF-alpha mRNA and protein with in situ hybridization (ISH) and enzyme-linked immuno-sorbent assay (ELISA) respectively. Meanwhile, the level of lipase and amylase in the serum was assayed and the pathological change was evaluated. RESULT: NF-KappaB activation in the pancreatitis group was higher than that in the control group (P<0.01), peaked at 3 hours, and was depressed by the inhibitor of NF-KappaB, NAC. The expression of TNF-alpha as well as the level of lipase and amylase in the serum also rose synchronously with activation of NF-KappaB. In contrast to group A, it was significantly different (P<0.01) in group B. After using NAC in group C, all of these values were decreased and the inflammatory reaction in the pancreas abated evidently. The pathology changes of the pancreas were shown to be alleviated in group C. CONCLUSION: First, NF-KappaB activity is intensively initiated in the course of pancreatitis and shown to have closely relationship with the release of cytokines. Second, use of NAC markedly depressed NF-KappaB activation. TNF-alpha expression is down regulated by cytokines. It is suggested that NAC probably acts as a useful agent for treatment of pancreatitis by indirectly inhibiting activation of NF-KappaB.     

具有时滞和扩散的Beddington-DeAngelis功能性反应的捕食-食饵模型的周期解

研究具有时滞和扩散的Beddington-DeAngelis功能性反应的捕食-食饵模型,利用重和度理论探讨了此模型在周期情形下周期解的存在性.     

B4C改性酚醛树脂对Si3N4的高温粘接性能

以酚醛树脂为基体,加入B4C作为改性填料制备出高温粘结剂,并对Si3N4陶瓷进行粘接.在300～800 ℃温度范围内对Si3N4陶瓷粘接试样进行热处理,并测试了不同温度热处理后的室温剪切强度.结果表明,经过700～800 ℃热处理后,粘结剂表现出较为理想的粘接性能,剪切强度测试结果为Si3N4陶瓷基体破坏.利用扫描电镜研究了粘接试样的断面形貌及胶层结构特征.研究表明,在高温热处理过程中,B4C改性填料发生了复杂的物理、化学变化,通过B4C与树脂挥发分之间的改性反应,有效提高了酚醛树脂热解后的残炭值,进而改善了粘接胶层结构的高温稳定性;纤维状物质的形成与B2O3颗粒的细化,有助于提高粘接胶层的连接强度.     

黑木耳子实体水溶性多糖的分离纯化及其部分理化性质和生物效用

黑木耳(Auricularia auricula)子实体的水溶性多糖经提取、脱蛋白、分离和纯化,得单一均匀组分 WEAⅡ。实验证实 WEAⅡ对供试微生物菌株无毒性,对由二甲苯所致小鼠耳壳炎、醋酸引起的小鼠扭体反应均有显著的抑制作用,能显著延长小鼠热板反应时间。     

具有Crowley-Martin型功能性反应的非自治捕食者-食饵系统的正周期解

主要考虑了具有Crowley-Martin型功能性反应的非自治捕食者-食饵系统的正周期解问题.在系统参数是周期的情形下,利用重合度延拓定理建立非自治捕食者-食饵系统的正周期解和边界周期解的存在性.最后,利用数值模拟验证和补充了该理论结果.     

微生物发酵蛋白饲料在奶牛饲养中的应用研究

本研究利用黑曲霉和米曲霉组合发酵豆粕、棉粕和菜粕等农副产品生产发酵蛋白饲料. 在四川、陕西、新疆三省(区)6个规范化奶牛场, 共选择339头的中后期泌乳奶牛, 进行对比饲养试验. 结果表明: (1)降低原奶中体细胞达88～175万个/ml, 说明该发酵蛋白饲料对提高奶牛抗病力、防治乳房炎具有显著效果;(2)提高产奶量, 试验组奶牛比照组平均多产奶1.08kg/头/天;(3)对乳蛋白、乳脂肪、乳蛋白和乳中固体物有均提高趋势, 但多数差异不显著;(4)饲料成本降低, 经济效益提高, 试验组奶牛比对照组奶牛每头每天多收益6.50元.     

用消炎止痛糊剂治疗口腔急性根尖炎的临床研究

目的 观察评价消炎止痛糊剂治疗口腔急性根尖炎的临床效果.方法 50例患者随机分为治疗组和对照组,对照组常规治疗,治疗组用?肖炎止痛糊剂,观察治疗效果.结果 治疗3 d后,治疗组临床疗效显著.结论 应用消炎止痛糊剂较常规根尖炎治疗方法的止痛效果非常明显.     

炭疽杆菌与炭疽病

炭疽杆菌为革兰氏染色阳性芽胞杆菌，可通过破损的皮肤或粘膜、呼吸道及肠道侵入人体，并繁殖产生强烈的毒素，使局部形成坏死性炎性改变。当机体抵抗力低弱时，病原菌可由局部病灶侵入血液循环或经淋巴管形成败血症或进而播散至脑膜、肺及肠，严重损害人体健康，甚至危及生命。因此，炭疽杆菌及其毒素被某些国家选为主要的生化武器。