Development of an analytical method to determine phenolic endocrine disrupting chemicals in sewage and sludge by GC/MS

An analytical method has been developed to determine hisphenoi A and five degradation products of alkyiphenoi ethoxylates in sewage and sludge. The parameters of accelerated solvent extraction （ASE） were optimized. C18 cartridge was used to clean up the sewage and the extract of sludge. The sensitivity of the mass detector was improved by adjusting the voltage of the lens manually. The instrumental detection limit was 3.2-17.8pg. The method detection limits were 2.5-11.4 ng/L and 0.3-2.1ng/g for sewage and sludge analysis respectively. The recovery and relative standard deviation for sewage analysis were 79.2%-111.4% and 6.9% - 12.6%; for sludge analysis were 68.5% - 114.0% and 8.9%-16.0%. Finally this method was applied to determining the phenolic endocrine disrupting chemicals in sewage and sludge from a sewage treatment plant in Beijing.     

春季小心"精神异常"

春天是万物复苏的季节，但也是各类精神疾病的多发期。春天气压较低，容易引起人脑分泌的激素紊乱，诱发精神分裂症等多种重型精神病；而春季连绵的阴雨天气则是抑郁症高发的外部因素；春天多变的气候也会使正常人情绪波动加快。     

瑞舒伐他汀钙干预对高尿酸血症所致大鼠内皮功能紊乱的影响

 为探讨瑞舒伐他汀钙(rosuvastatin)对高尿酸血症大鼠模型及其内皮功能紊乱的影响,将72只Sprague-Dawley(SD)雄性大鼠随机分组,采用酵母膏和氧嗪酸钾腹腔注射方法,建立高尿酸血症动物模型.设别嘌呤醇干预为阳性对照,以2.5、5.0和10.0mg瑞舒伐他汀钙/kg剂量干预动物模型,采用专用试剂盒测定尿酸(UA)、一氧化氮(NO)、内皮素-1(ET-1)、血管紧张素II(AngII)的血清水平,免疫组织化学鉴定主动脉组织的一氧化氮合酶(eNOS)蛋白质表达水平变化.结果显示,与对照组比较,高尿酸血症动物模型组血清UA、ET-1和AngII显著升高,血清NO降低,主动脉内皮组织eNOS表达水平降低.瑞舒伐他汀钙干预动物模型后发现,随着药物剂量和干预时间的增加,该药改善以上内皮功能紊乱相关的指标,使之逐渐恢复至正常水平,当瑞舒伐他汀钙干预剂量为10mg/(kg·d)和干预6周时,与非药物干预的模型组有显著差异,其改善内皮功能效果明显高于嘌呤组(阳性对照组).由此表明,瑞舒伐他汀钙通过升高血清中NO和eNOS的蛋白表达,降低血浆ET-1及AngII,从而改善高尿酸血症大鼠的血管内皮功能,并且该作用呈剂量依赖性.     

著名病理生理学家--赵克森教授

赵克森教授,我国著名的病理生理学家,国际休克学会联盟(IFSS)的创建人之一。现为国务院学位委员会学科评议组成员,南方医科大学(原第一军医大学)病理生理教研室教授,博士生导师。 1987年在日本东京第四届微循环大会的闭幕式上,大会主席土屋雅春教授向赵克森教授颁发了奖状,奖励他对"白细胞在休克微循环紊乱中的作用"     

Research progress of the endocrine disrupting activities of polychlorinated biphenyls

Polychlorinated biphenyls (PCBs) arc global persistent organic pollutants. Almost all commercial PCBs mixtures, single PCB congener, and their metabolites possess endocrine disrupting activities. They can disrupt the estrogen/androgen system, thyroid hormone system and other endocrine systems by interfering with the synthesis, transport, storage, metabolism, and feedback regulation of hormones. The newest data related to the endocrine disrupting activities of PCBs and their mechanisms arc reviewed and the research perspectives arc also discussed.     

健康的一半是心理健康

随着社会的进步及科学技术的发展,使我们对健康的概念有了更进一步的认识和理解。健康的人不但在生理上没有疾病,在心理上也应该是健康的,只有身心俱佳,对社会有良好适应的人,才算是一个真正的健康者。巴普洛夫说过:“一切顽固沉重的忧郁和焦虑足以给各种疾病大开方便之门”。心理的异常变化,可以使神经系统功能紊乱,最终导致循环系统、消化系统、免疫系统等机能失去平衡而引起一系列病变。所以说,对某些因心理因素导致的病症,心理治疗是必要的。     

Quantitative structure-activity relationship of estrogen activities of bisphenol A analogs

BISPHENOL A (4,4-ISOPROPYLIDENEDIPHENOL, BPA) IS MANUFACTURED IN HIGH QUANTITIES, WITH 90% OR MORE BEING USED AS A MONOMER FOR THE PRODUCTION OF POLYCARBONATE AND EPOXY RESINS, UNSATURATED POLYESTER-STYRENE RESINS AND FLAME RETARDANTS. THE FINAL PRODUCTS …