Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

The controlling factors and distribution prediction of H2S formation in marine carbonate gas reservoir, China

Generally, there are some anhydrites in carbonate reservoir, as H2S is also familiar in carbonate oil and gas reservoirs. Nowadays, natural gas with high H2S concentration is usually considered as TSR origin, so there is close relationship between H2S and anhydrite. On the contrary, some carbonate rocks with anhydrite do not contain H2S. Recently, researches show that H2S is only a necessary condition of H2S formation. The reservoir porosity, sulfate ion content within formation water, reservoir temperature, oil/gas and water interface, hydrocarbon and some elements of reservoir rock have great controlling effects on the TSR occurrence. TSR deoxidizes hydrocarbon into the acidic gas such as H2S and CO2, and the H2S formation is controlled by TSR occurrence, so the relationship among reaction room, the contact chance of sulfate ion and hydrocarbon, the reservoir temperature has great influence on the TSR reaction. H2S has relatively active chemical quality, so it is still controlled by the content of heavy metal ion. Good conditions of TSR reaction and H2S preservation are the prerequisite of H2S distribu- tion prediction. This paper builds a predictive model based on the characteristic of natural gas reservoir with high H2S-bearing. In the porosity reservoir with anhydrite, the formation water is rich in sulfate and poor in heavy metal ion. Oil and gas fill and accumulate in the gas reservoir with good preservation conditions, and they suffered high temperature later, which indicates the profitable area of natural gas with high H2S-bearing.     

国内科技期刊亮点

"直接法"测定蛋白质晶体结构新方法我国科学家近年来在发展"直接法"测定蛋白质晶体结构的研究方面,提出了一种处理单对同晶型置换数据的新方法。     

福建省淡水鱼类寄生单殖吸虫名录

1964-1965年福建省进行鱼病调查时，从60余种淡水鱼鱼体上收集到一批单殖类吸虫标本。经笔者鉴定隶属于3目、5科、12属，80余种。本文现就其中的3目、4科、11属、72种的学名，寄主及分布情况先予以报导。     

维生素D

维生素D是一种脂溶性维生素，也被看作是一种作用于钙、磷代谢的激素前体，它与阳光有密切关系。维生素D在人类中的主要生理功能是维持血清钙和磷的浓度在正常范围内，维持神经肌肉功能正常和骨骼的健全，它是生命必需的营养素和钙代谢的最重要生物调节因子。     

SrFCl:Eu~(2+)晶体的电子自旋共振谱研究

用程序降温法生长了SrFCl:Eu~(2+)晶体,并测量了它的电子自旋共振谱。应用最小二乘法拟合技术对g因子及自旋哈密顿参数进行了精确拟合。报道了各向异性的g因子及有关自旋哈密顿参量。发现并归属了Eu~(2+)的高阶禁阻跃迁。     

偏头痛的遗传:从性性状的遗传假说

偏头痛被公认为一种家族高聚集性神经系统疾病 ,尽管欧美白种人群的患病率远高于亚洲人种 ,但全球范围内的患病率女性是男性的 2～ 4倍却是恒定的 .临床及遗传医学仅仅沿用常染色体显性或染色体隐性遗传、多基因遗传及线粒体遗传理论均不能满意地解释所有家系的特征 ,笔者率先在国际上提出的从性性状遗传模式sex conditionedgeneticmodel(即男性为常隐、女性为常显遗传 )似可较好地解释偏头痛复杂的“不一致”的遗传方式 .自然界中的生物体内一条染色体的基因会对另一条染色体致病基因的表达实施功能调控 ,此种遗传疾病范例在遗传性秃顶、肝豆状核变性等症中已得到验证 .当然对于环境的因素也有待考虑 ,时下对于复杂遗传病的研究正是最富有挑战性的 .     

余龙 中国基因科学的耕耘者

人类基因研究领域是一个奥妙无穷的科学神殿,同时又是一个深不可测、浩瀚无际的聚宝盆。目前科学家在这个领域的工作状态如同一只小蚂蚁在啃一块大骨头:科学家正一步步探索着这座神秘的宫殿,一点点啃噬着这块可造福于人类的宝藏,攻下一关,庆贺一番;啃下一块,抢而食之;科学家们既要有蚂蚁啃骨头、耐得住寂寞的“坐功”,又要有不顾斯文“抢食吃”的竞争意识。谁耐得住寂寞,持之以恒,谁就会有收获;谁的工作群体战斗力更高,竞争意识更强,谁的收获就会更加丰盛。     

偏心因子数据的计算方法研究进展

从偏心因子(acentric factor)的定义出发，分析了ω数据的确定方法和获取数据的手段，评述了国内外ω计算方法的近期进展，包括对应态蒸气压关联方程法、对应态基团贡献法(CSGC)、图论法及拓扑法等，指出了各种方法的优缺点及最新的计算发展方向。