miRNA与肿瘤发生

肿瘤发生的机制是细胞出现失控性增殖。肿瘤的发生一直被广泛认为是由于一系列癌基因蛋白和抑癌基因蛋白的开放读码框的突变而逐步形成的。随着非编码RNA（ncRNA）的发现，传统观念正被改变。最近的研究表明非编码RNA中的成员miRNA可能对于肿瘤的形成起着重要的调控作用。 miRNA（microRNA）是一类高度保守的非编码RNA（ncRNA），长度一般为19—25nt的单链型RNA（ssRNAs），由60．110nt的可形成发夹状的内源性转录前体加工而成。miRNA与靶mRNA的3’UTR碱基配对，通过抑制mRNA的翻译或直接使mRNA降解，在转录后水平使基因产生沉默。越来越多的证据显示由miRNA调节的基因调控机制作为基因表达水平调控的一种重要方式，与肿瘤的发生密切相关。     

把基因分析引进人类学——人类学学者访谈录之三十九

结合自身的研究,探讨了遗传学在人类学的应用及前景问题,如体质人类学、医学人类学、分子人类学、考古人类学等分支领域。     

Mapping of the rice （Oryza sativa L.） thermo-sensitive genic male sterile gene tms5 with EST and SSR markers

VELOPING“TWO-LINE”HYBRID RICE.THE POLLEN FERTILITY OF TGMS IS REGULATED BY THE TEMPERATURE OF ENVIRONMENT.THE POLLENS OF TGMS LINES ARE STERILE WHEN THE ENVI-RONMENT TEMPERATURE IS ABOVE A CRITICAL POINT,BUT FERTILE BELOW THIS POINT.SO FAR,A NUMBER OF T…     

Strategy for the mapping of interactive genes using bulked segregant analysis method and Mapmaker/Exp software

A qualitative trait is usually controlled by a single gene, but it may be sometimes controlled by two or even more genes. This phenomenon is called gene interaction. Rapidly searching for linked mo- lecular markers via bulked segregant analysis (BSA) and then constructing regional linkage map with Mapmaker/Exp has become a common approach to mapping single major genes. However, methods and computer programs developed for mapping single major genes cannot be simply applied to interactive genes because the genetic patterns of gene interac- tions are quite different from that of single-gene in- heritance. Up to now, experimental methods for quickly screening molecular markers linked to inter- active genes and statistical methods and corre- sponding computer softwares for simultaneously analyzing the linkage relationships of multiple mo- lecular markers to an interactive gene have not been available. To solve this problem, in this paper, we propose a strategy for mapping interactive genes using BSA and Mapmaker/Exp. We demonstrate that all interactive genes can be mapped by the 'BSA Mapmaker/Exp' strategy using F2 generation (in a few cases, F3 generation is also needed). As BSA and Mapmaker/Exp have been broadly used in gene mapping studies and are well known by many re- searchers, the strategies proposed in this paper will be useful for practical researches.     

Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice （Oryza sativa L.）

A rice psl1 （presenescing leaf） mutant was obtained from a japonica variety Zhonghua 11 via radiation of ^60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the biggest length, while the leaves of the wild variety could keep green for 25--35 d. In this study, genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene （psl1） located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nipponbare and 93-11. The psl1 was further mapped between two STS markers, STS2-19 and STS2-26, with genetic distances of 0.43 and 0.11 cM, respectively, while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus, the region being delimited to 48 kb. This result was very useful for cloning of the psl1 gene.     

幼虫的起源

长期以来，幼虫和成虫是由同一基因物种进化而来这一假设与许多生物学现象有着难以调和的矛盾。本书的作者提出了一个大胆的猜想——决定幼虫形态的相关基因可能是由不同种类动物交互移植而来，并通过举例论证了这一幼虫基因移植论的可行性。     

OFDM信号保护间隔的设计方案

在无线通信中，由于无线信道的多径衰落极大地恶化了通信质量。为了达到优良的误码率性能。考虑在传送通路上产生的多径衰落状态和符号同步的位置是重要的，合适的保护间隔（GI）设计是必须的。在OFDM通信方式中，把指数函数型延迟作为多径环境的模型，从传送效率和误码率特性的角度出发，研究了关于在发送端应附加的GI长度和接收端应去除的GI长度的设计方法，在考虑同步误差时，使OFDM具有能承受多径衰落的优良特性。     

基于多服务等级随机网络系统价控策略分析

引进多服务等级随机网络系统的用户需求量与价格模型,讨论了定价策略问题,同时给出了用户需求量的无偏估计.对于用户呼叫到达时间服从于几何分布的网络系统,制定了静态无激励定价策略.对一般较复杂网络模型制定了动态定价策略,该策略可调整用户需求估计量均值,使网络取到最大收入.由于用户需求量是一随机变量,对系统施加点激励价控策略,激励和引导用户选择对网络整体有利的服务请求.建立的定价策略,可提高网络资源的利用率,控制网络拥塞,较适合于目前网络日益发展的需要.     

分析法在多进制数字调制教学中的应用

就通信原理课程中多进制数字调制的教学难点进行了讨论，以8PSK为例对多进制数字信号的产生与信号的解调进行了分析。     

多普勒雷达机房附属设施远程控制系统

给出一种使用公用电话网进行远程控制雷达机房附属设施的系统。该系统采用普通双音多频电话机上的按键,作为控制命令按键,通过MT8870双音调多频接收机作电话双音多频解码核心,实现对雷达机房附属设施远程控制功能。