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10月30日，南京师范大学、华大基因等单位的科研人员成功破泽了白暨豚全基因组图谱，为解析白黯豚独特的生活爿性及进化历程奠定了重要的遗传学基础，同时也为哺乳动物尤其是鲸类的研究与保护提供了宝贵资源。     

兰花基因组计划：探索生命进化之谜

从达尔文开始，在随后的200多年时间里，兰花一直是进化生物学家关注的焦点，对它们的观察和研究从来没有停止过。1903年，喙长25厘米的天蛾的发现，证实了达尔文关于彗星兰传粉者的预测；2003年，眉兰花香成分的测定，证实了这种兰花是依靠释放假的“性激素”来诱骗雄胡蜂传粉的。越来越多的研究，让我们逐步认识了千奇百怪的兰花。     

万钢:加强我国全球变化的协调集成研究已迫在眉睫

<正>7月9日,科技部部长万钢强调说,以全球气候变化为主要内容的全球变化问题日益突出,将成为人类可持续发展最严峻的挑战之一,大力加强我国全球变化的协调集成研究已经迫在眉睫。全球变化研究是研究地球系     

个人基因测序有多远

基因测序技术不但能锁定个人病变基因,还能提做到提前预防和治疗。但有专家担心这些全基因检测普及,一旦落入保险公司或者被测者雇主的手中,将会对人们的生活产生不良影响。     

灵芝基因组框架图已经完成

《自然通讯》(Nature Communications)6月报道,有着"不死药"美誉的中国仙草——灵芝(Ganoderma lucidum),其基因组框架图已于近日绘成。该项目由中国医学科学院药用植物研究所、美国田纳西州大学健康科学中心和威斯康星大学麦迪逊分校等机构的研究人员联合完成,通讯作者是中国医学科学院药用植物研究所的陈士林所长和孙超博士。灵芝,不仅在中国久负盛名,在世界范围内也是众所周知的一种药用大     

Accurate localization and excision of genomic islands in four strains of <Emphasis Type="Italic">Pseudomonas aeruginosa</Emphasis> and <Emphasis Type="Italic">Pseudomonas fluorescens</Emphasis>

Mobile genomic islands (GIs) can be excised from the chromosome, then form a circular intermediate and be reintegrated into the chromosome by the GI internal integrase. Some mobile GIs can also be transferred into a new receptor cell by transformation, conjugation, or transduction. The action sites of the integrase are usually flanked direct repeats (DRs) of the GIs. Accurate localization of the flanking sequences is a precondition for determining the mobility of the GI. Mobile GIs are generally associated with transfer RNAs (tRNAs). Based on the correlation between flanking sequences and tRNA sequences, the flanking sequences of 11 putative mobile GIs in Pseudomonas aeruginosa PAO1, P. aeruginosa PA14, P. fluorescens Pf-5 and P. fluorescens Pf0-1 were identified. Among the 11 GIs, Pf0-1GI-1 is responsible for benzoate degradation. PAO1GI-1, Pf5GI-2, Pf5GI-3, and Pf5GI-4 were confirmed experimentally to be excised from a chromosome to form a circular intermediate. The action sites of the integrases are these GIs direct repeats. Due to distinct DRs, cutting sites for the internal integrase of PAO1GI-1, Pf5GI-2, Pf5GI-3 and Pf5GI-4 were determined outside the T-loop of the tRNA^Gly gene, outside the anticodon loop of the tRNA^Ser gene and tRNA^Lys gene, and at the asymmetric 3′-end of the tRNA^Leu gene, respectively. PAO1GI-1 and other mobile GIs may be transferred into many different strains that belong to different phyla because of the clear flanking sequences. This study describes basic information about the action sites of the integrases, assesses the mobility of GIs, and can help design and transfer mobile GIs to candidate strains.     

DNA damage,signaling and repair: Protecting genomic integrity and reducing the risk of human disease

DNA is the genetic material that contains the "instructions" to not only guide the continuation of life but also govern the development, metabolism and functioning of living organisms. DNA damage occurs daily due to various exogenous (environ-     

公益工商研究所始末

本文系统地介绍了由中国最大的民族资本集团——荣家企业经营的公益工商研究所的创办过程及其所进行的研究课题和所取得的成果。文中指出该所是为荣家企业的生存和发展服务的,是集工业、科技、经济于一体的研究机构。     

C─值悖论及其机制

基因组大小，即Ｃ值，与基因组中所含的遗传信息的认定数量间缺乏对应，这种Ｃ一值悖论是由非基因ＤＮＡ的增加所造成的．     

X染色体的一个新的STS的创建

构建人基因组分辨率为100kb的STS(Sequene tagged sites)是今后5年的目标之一,为此需要创建3万个STS.1989年Olson等人首次提出STS图谱分析的概念,认为STS图谱可以作为染色体的骨架图(framework map)的位标(landmark).STS是人基因组中长为数百bp的单拷贝序列,它们的核苷酸顺序是已知的,在染色体上的位置已确定,并可以用PCR方法在基因组其它序列存在的情况下进行检测.