Visualization of Gene Mutation Complicated Pattern of Hepatitis B Virus Based on Cellular Automata

Hepatitis B virus shows instantaneous and high rate mutations in biological experiments, some sorts of which affect the efficiency of virus replication greatly through enhancing or depressing the viral replication, while others have no influence at all. Taking advantage of prominent features of cellular automata, we simulate the effect of hepatitis B virus gene mutation on its replication efficiency. The computer simulation results demonstrate the feasibility of our novel model by comparing with the results of biological experiments.     

癌症起因的争论在继续

癌细胞着实可怕 ,充满着失活的基因 ,染色体的多余或缺失 ,以及许多其他大大小小的遗传异常。研究人员大都同意 ,多数癌症是几种异常变化积累起来的结果———有的变化使某些肿瘤抑制基因消失了 ,有的使促进癌生长的基因激活了。但癌细胞早期怎样会发生如此多的突变和染色体异常的 ,人们看法不一。争论的焦点是基因组不稳定性的作用 :某些先天性缺陷是否使癌细胞的基因组比正常细胞对癌变更具有敏感性。约翰·霍普金斯大学的Ｂ·沃格尔斯坦 (Ｂ Ｖｏｇｅｌｓｔｅｉｎ)认为 ,要认识癌症 ,必需能回答有关基因组不稳性对癌变所起到作用的许多…     

Micronuclei rate and hypoxanthine phosphoribosyl transferase mutation in radon-exposed rats

The genetic changes in rats with radon exposure were studied by the micronucleus technology and detection of hypoxanthine phosphoribosyl transferase （hprt） mutations. The rate of the micronuclei in peripheral blood lymphocytes and tracheal-bronchial epithelial cells in the radon-inhaled rats was higher than that of the controls （P 〈 0.05）. A similar result was obtained from the hprt assay, which showed a higher mutation frequency in radon-exposed rats. Our results suggested that micronuclei rate and hprt deficiency could be used as biomarkers for the genetic changes with radon exposure.     

急性髓细胞白血病中转录因子GATA—2基因的表达和？…

目的：分析急性髓细胞白血病（ＡＭＬ）中转录因子ＧＡＴＡ－２基因的表达和突变情况。方法：应用反转录－多聚酶链反应（ＲＴ－ＰＣＲ）检测８５例ＡＭＬ的ＧＡＴＡ－２基因表达情况。２５例正常人的外周血或骨髓作为对照。结果：８５例ＡＭＬ中７６例表达了ＧＡＴＡ－２基因。各ＡＭＬ亚型均见ＡＧＴＡ－２表达。在８５例ＡＭＬ发现２例出现至今未报道的ＧＡＴＡ－２基因的突变。在一例ＡＭＬ－Ｍ２病人发现ＧＡＴＡ－２ｃＤＮＡ     

哺乳动物起源、进化模糊问题思考

哺乳动物进化是生物进化的重要组成部分之一,是生物进化论、动物学研究的重要内容之一。根据古生物学、现代生物学、生物进化论研究成就,就哺乳动物确定、起源、翼手目进化、水栖哺乳动物进化中的模糊问题进行了分析思考。     

Short Review： Mitochondrion and its related disorders： Making a comeback

The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.