尼古丁-FET传感器的研制

尼古丁是烟草中最重要的生物碱。本文报导以四苯硼酸尼古丁缔合物为活性材料,研制了尼古丁场效应管传感器,测试了器件的性能参数,获得满意的结果。其线性范围在10~(-1)～10~(-4)mol/l,斜率为56±1mV/pc,适用的 pH 范围在5.5～7.5之间。     

Permeation study of the potassium channel from streptomyces Lividans

A three-state hopping model is established according to experiments to study permeation of an open-state potassium channel from Streptomyces Lividans (KcsA potassium channel). The master equations are used to characterize the dynamics of the system. In this model, ion conduction involves transitions of three states, with one three-ion state and two two-ion states in the selectivity filter respectively. In equilibrium, the well-known Nernst equation is deduced. It is further shown that the current follows Michaelis-Menten kinetics in steady state. According to the parameters provided by Nelson, the current-voltage relationship is proved to be ohmic and the current-concentration relationship is also obtained reasonably. Additional validation of the model in the characteristic time to reach the steady state for the potassium channel is also discussed. This model lays a possible physical basis for the permeation of ion channel, and opens an avenue for further research.     

Relationship between Earth-Sun-Moon 1000 Ma ago： Evidence from the stromatolites

Stromatolitesareusuallyinterpretedastheorgano-sedimentarystructurescausedbythegrowthandmetabo-lismofmicro-organisms,principallycyanobacteriaandprecipitatedmineralgrainstrappedtothestickylay-ers[1—5].Asthesunlightisstrongindaytime,thealgaefila-mentsshowstrongactivityinphotosynthesisandgrowtowardsunlight.Ontheotherhand,asthesunlightisweakatnight,thealgaefilamentsshowinactivityinphotosyn-thesisandgrowhorizontally.Duringthecourseofgrowth,thealgaewillproducesomeglutinoussecretionwhichcancatchsedim…     

试析马王堆文明的特点

吴氏长沙国创造了马王堆文明.它的特点有:汉初农业与家庭纺织业相结合是马王堆文明的基础;维护刘氏封建王朝是马王堆文明的大目标;推行"黄老之学"是马王堆文明的统帅.之所以会有这些特点,是因为有长沙国政权的组织、湘中河谷平原的优越条件、楚文明的深厚底蕴及斗争形势使然.     

MRS study on lentiform nucleus in idiopathic Parkinson‘s disease with unilateral symptoms

OBJECTIVE: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson's disease. METHODS: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), Creatine (Cr) and Choline (Cho) were calculated. RESULTS: Compared to that in the control, NAA/ (Cho+Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P<0.05); while there was no difference between the two sides in the healthy volunteer (P>0.05). The ratio of NAA/(Cho+Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P<0.05). CONCLUSIONS: There might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson's disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis.     

21世纪图书馆文献信息人员的自我更新势在必行

走进21世纪,严峻的现实使我们更加认识到,经济对知识的依赖性越来越强.任何一个人单凭一方面专长已无法适应多变的环境要求,精一门、专一门、学三门,终身受教育,已成为愈来愈多的人的共识.早在1994年11月国际社会就于意大利罗马举行的"首届世界终身学习会议"上,提出"终身学习是21世纪的生存概念".这势必要求我们通过学习,吸取新知识、新信息和提出问题的能力,不断进行自我更新,变"学会"为"会学".     

阳极溶出半微分电分析法测定纯水和纯试剂中痕量杂质

本文提出应用具有灵敏度高、分辨率好、峰高易于准确测量等特点的汞膜电极阳极溶出半微 分电析法进行各种纯水和一些常见支持电解质中痕量重金属杂质的测定方法，并探索通过巯基棉 等分离方法对试剂进行提纯的效果． 实验表明：对于水样只要加入几滴盐酸，使其ｐＨ＝２．５左右即可进行测定，对于一些纯试剂 可直接进行测定，不必加入其他支持电解质，避免沾污。测定方法十分简便。 利用巯基棉除去一些试剂中痕量铜铅等杂质，进行试剂提纯，方法简便，效果良好。     

全固态激光及非线性光学频率变换技术

在众多的激光器件中,由半导体激光器泵浦的固体激光器（LDPSSL,简称全固态激光器）由于其转换效率高、光束质量好、工作稳定可靠,体积小、重量轻、寿命长,工作介质覆盖的波段广及运转方式多样,再加上与非线性光学频率变换技术相结合,可实现多种波长的动转,致使这类激光器具有逐步取代气体,游人本及传统固激光器的可能性,因此这类器件已经成为当前激光技术发展的主要方向,本文综述了全国态激光及非线性光学频率变换技术的发展及在激光与光电子领域中的地位与作用,概述了它们的基本理论,特点及关键技术,展示了其广阔的应用前景。     

二价铜离子对牛正常朊蛋白二级结构的影响

研究了二价铜离子对牛朊蛋白的二级结构的影响.牛朊蛋白(BoPrPc)的小分子(BoPrPcS)和大分子(BoPrPcL)经初步纯化后,在含Cu2+的碱性溶液中氧化,用反相柱进行氧化态和还原态的BoPrPcL和BoPrPcS的分离.质谱分析证明氧化态的Bo-prPcL和BoPrPcS分子质量分别为24.064,15.819ku.用远紫外圆二色谱(Far-UVCD)分析显示,BoPrPcS在208和222m处出现两个负峰,为典型的α-螺旋型结构;而Bo-PrPcL在222nm处负峰减小.与未经氧化的BoPrPcL的质谱和CD结果比较后发现,氧化后的BoPrPcL在八肽重复区结合了6个Cu2+,其β-折叠含量明显增加.而Cu2+对BoPrPcS二级结构基本无影响.BoPrPcL结合Cu2+的特性及其二级结构的相应变化可能与细胞内抗Cu2+毒性与氧化压力有关.     

研究文化保守主义的一部力作－评沈卫威《回眸“学衡派”》

作为主流文化的反面和制衡,"学衡派"与中国现代文化的发展息息相关.沈卫威博士的专著<回眸"学衡派">是一部研究文化保守主义现代命运的力作.沈博士令人信服地解决了这个独具特色文化派别的历史评价问题;对"学衡派"三位核心人物的个案研究也有许多新的见解和突破.