OMOM capsule endoscopy in diagnosis of small bowel disease

Objective： To assess the diagnostic efficiency of OMOM capsule endoscopy （CE） in a group of patients with different indications. Methods： Data from 89 consecutive patients （49 males, 40 females） with suspected small bowel disease who underwent OMOM CE （Jinshan Science and Technology Company, review. The patients＇ indications of the disease consisted of the Chongqing, China） examination were obtained by retrospective following： obscure gastrointestinal bleeding （OGIB）, abdominal pain or diarrhea, partial intestinal obstruction, suspected inflammatory bowel disease, tumor of unknown origin, hypoproteinemia, constipation, weight loss, and elevated tumor markers. Results： CE failed in one patient. Visualization of the entire small bowel was achieved in 75.0%. Capsules were naturally excreted by all patients. The detection rate of abnormalities was 70.5% for patients with suspected small bowel disease, and the diagnostic yield for patients with OGIB was higher than that for patients with abdominal pain or diarrhea （85.7% vs 53.3%, P〈0.005）. Angiodysplasia was the most common small bowel finding. Active bleeding sites were noted in the small intestine in 11 cases. Conclusion： OMOM CE is a useful diagnostic tool for the diagnosis of variably suspected small bowel disease, whose diagnostic efficiency is similar to that of the Pillcam SB （small bowel） CE （Given Imaging, Yoqneam, Israel）.     

奥美拉唑配合胃腔降温治疗老年急性上消化道大出血疗效观察附45例报告

急性上消化道大出血是老人急症之一。３年来我院收治４５例,年龄６０～９１岁,平均年龄７０３岁。３７例经纤维胃镜检查：消化性溃疡２４例;急性胃粘膜病变、糜烂性胃炎１０例;胃癌２例;肝硬化并食道静脉破裂１例。大部分病人由于出血量多,入院时多处于休克状态,病情危重,需及时抢救。在综合疗效法基础上,联合应用奥美拉唑及胃腔降温,疗效满意,成功率达９５６％,２４ｈ内大部分患者止血。其作用机理：奥美拉唑是质子泵抑制剂,抑制Ｈ＋Ｋ＋－ＡＴＰ酶活性,对胃酸分泌有强而持久的抑制作用,使血小板能很好地凝集形成凝血块,减少Ｈ＋回渗致胃粘膜产生糜烂和溃疡,有利于止血。胃腔降温也可抑制胃酶分泌,抑制胃蛋白酶活性及血块溶解;冰冻盐水加入去甲肾上腺素、凝血酶等局部应用,可起到协同止血作用     

凝血酶治疗上消化道出血的临床观察

本文报道国产（深圳蛇口海王生物工程有限公司产品）凝血酶治疗上消化道出血３１例,取得良好疗效。１材料与方法１．１病例选择　治疗组３１例,对照组３３例均为１９９５年１月份～１９９６年７月份在本院住院病例,皆因黑便或呕血或先呕血后黑便而入院,入院后２４～４８ｈ立即进行胃镜检查明确病因,但有３例病人拒绝胃镜检查,治疗组男２６例,女５例,年龄１８～７４岁,平均５９岁;对照组２６例,女７例,年龄１９～６７岁,平均５５岁,病因诊断如下：１．２治疗方法病人入院后,在输液输血补充血容量的同时,治疗组用凝血酶１００…     

产后抑郁动物模型研究进展

产后抑郁症是一种复杂情绪障碍疾病。由于在发病模式中所表现出的生理特殊性与病理复杂性,使得在本病动物模型研究方面与单纯抑郁症之间存在较大差异。产妇分娩后所处的特殊时期,其发病与激素水平、神经递质及某些肽类物质含量、相关受体功能等方面改变密切相关。在人体上研究产后抑郁症有很多局限性,有些研究内容需利用动物模型完成。本文结合近年来国内外相关文献,对目前常用的产后抑郁症动物模型进行简要综述,以供基础及临床研究参考。