堆山工程软土地基Biot固结的非线性有限元分析

本文在文献[1]、[2]给出的软土地基Biot固结的有限元构式及程序基础上,对某大型堆山工程分级加荷施工过程中,软土地基的固结变形,附加应力及超孔隙水压力分布,塑性区的开展等进行了弹性非线性有限元的计算分析,得出了在理论和工程应用上一些有意义的结论。本文的计算方法和结果,可供工程技术人员在类似工程的初步设计时借鉴和参考。有些内容尚可进一步研究和探讨。     

Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer’s disease

Apolipoprotein E (apoE) ɛ4 allele is a genetic risk factor for late-onset familial and sporadic Alzheimer’s disease (AD). In the central nervous system, apoE is secreted mainly by astrocytes as a constituent of high-density lipoproteins. A recent study using apoE knockout mice provided strong evidence that apoE promotes cerebral deposition of amyloid β protein (Aβ). However, no clear explanation of the pathogenesis of apoE-induced AD has been provided. Here we discuss two possible mechanisms by which apoE might enhance Aβ deposition. One is the intracellular pathway in which apoE is internalized by neurons and induces lysosomal accumulation of Aβ and amyloidogenic APP (amyloid precursor protein) fragments, leading to neuronal death. The other is the extracellular pathway in which apoE-containing lipoproteins are trapped by Aβ1–42 deposits mobilizing soluble Aβ peptides and consequently enlarge amyloid plaques. These two mechanisms may operate at different stages of AD pathogenesis and suggest a chaperone-like function for the apoE molecule. Received 4 February 1999; received after revision 9 April 1999; accepted 23 April 1999     

Chemotherapy and immunotherapy of malignant glioma: molecular mechanisms and clinical perspectives

Despite the considerable progress in modern tumor therapy, the prognosis for patients with glioblastoma, the most frequent malignant brain tumor, has not been substantially improved. Although cytoreductive surgery and radiotherapy are the mainstays of treatment for malignant glioma at present, novel cytotoxic drugs and immunotherapeutic approaches hold great promise as effective weapons against these malignancies. Thus, great efforts are being made to enhance antitumoral efficacy by combining various cytotoxic agents, by novel routes of drug administration, or by combining anticancer drugs and immune modulators. Immunotherapeutic approaches include cytotoxic cytokines, targeted antibodies, and vaccination strategies. However, the success of most of these experimental therapies is prevented by the marked molecular resistance of glioma cells to diverse cytotoxic agents or by glioma-associated immunosuppression. One promising experimental strategy to target glioma is the employment of death ligands such as CD95 (Fas/Apo1) ligand or Apo2 ligand (TRAIL). Specific proapoptotic approaches may overcome many of the obvious obstacles to a satisfactory management of malignant brain tumors. Received 8 March 1999; received after revision 27 May 1999; accepted 14 June 1999     

简论翻译教学法在大学英语教学中的应用

翻译教学法有自身的特点和优势,在当前大学英语教学中仍然发挥着十分重要的作用。但是,翻译教学法也有自身的局限性,在大学英语教学中也存在问题,应采取积极措施加以解决。     

高中《信息技术》新课程标准实施对高校计算机基础教学的影响

高中《信息技术》课程的实施对高校计算机基础教育产生了积极的影响,同时也对大学计算机基础教育提出了更高的要求。     

高校图书馆与大学生心理健康教育

分析了当前大学生的心理特点及存在的心理问题,阐述了高校图书馆开展读者心理咨询的优势,提出了高校图书馆开展大学生心理健康教育的途径与方法。     

认识信息传播规律 拓展高校信息服务领域

对信息传播规律进行了较深入的研究,包括“信息—媒介”的关系以及“信息—媒介—受众”的规律,论述了拓展高校的信息服务领域及服务反馈的问题。     

试论"因材施教"在现代高校教育中的实现途径

现代高校规模化、标准化的分类(专业)教育方式,不但不排斥“因材施教”,反而为这种教育思想的深入贯彻搭建起了更为科学和完整的系统平台。与古代原始的“因材施教”,注重处理教师与学生个体关系的方法不同,这种大系统平台上的“因材施教”的实施方式与实现途径更为复杂,科学性要求更高。它追求通过多方面、多因素的科学协调整合过程或系统构筑过程,达到学生主观志趣与其个性特质的统一;学校专业教育与特色人才成长规律的统一;“施教”内容与培养对象的“材质”和社会需求的统一。     

此情可待成追忆——胡兰成《今生今世》评说

胡兰成的《今生今世》是一部颇具争议性的奇特作品。晚年胡兰成在这部作品中,倾注了他对故乡、童年、和父母的深情回忆。文字风格妩媚委婉,情感极为细腻敏感,可以看作中国散文中的奇葩。     

论构建协调人民利益矛盾的有效机制

由于人民利益矛盾日益表现为人们内部的主要矛盾,因此我们只有在公正、平等和有序原则的基础上,建立人民利益矛盾协调的有效机制,才能使整个社会呈现长期和有效的发展势头。