识别同谱图的实用算法

所谓同谱图是指邻接矩阵不置换相似但具有相同特征多项式的图.在化学上,它表示休克尔分子轨道能谱相同,但对分子结构不同的共轭碳氢化合物,从理论上要识别两个图是否同谱.并给出判别准则,是图论与分子轨道理论目前正在探讨的问题.另从计算的角度出发,给出确定图的邻接矩阵特征多项式的准确快速算法,对于判断给定的图是否同谱,进而检验某些与此有关的理论与猜想也是十分有意义的.在文献[1]中,曾因计算过程中数字膨胀过快,而对利用牛顿公式确定0-1矩阵的特征多项式的方法加以怀疑,本文在分析利用牛顿公式确定休克尔矩阵(每一列最多有三个     

基于Hedonic模型的广州地铁1号沿线住宅价格分析

地铁提高了沿线区域的通达性,大大降低了沿线居民的通勤成本,对沿线房地产价格产生深远影响．文章以广州市地铁1号线为例,选取了在2009年1～3月份成交的沿线100个住宅单元作为分析对象,利用Hedonie半对数模型分析其价格的影响因素．研究设计了建筑特征、邻里特征及区位特征3大类共13个因子参与模型运算,最后获取对住宅价...     

蓝光抑制har1中胚轴伸长中ABA含量和相关基因的表达变化

分析了蓝光介导的高粱航空诱变突变体har1中胚轴伸长抑制过程中,蓝光信号途径关键组分基因SbCRY1 b、SbCOP1和SbHY5的表达水平变化,研究表明,har1对蓝光的超敏感可能与其中SbCRY1 b表达水平升高有关.外源ABA增加了蓝光对R111中胚轴的伸长抑制程度,抑制剂NAP(Naproxen)在一定程度上可以缓解蓝光对har1中胚轴的抑制.同时,蓝光处理后har1中胚轴中内源ABA含量增加程度较R111更为显著,初步表明ABA参与蓝光介导的高粱幼苗中胚轴伸长抑制反应.     

基于缓冲算子的灰色瓦斯涌出量预测研究

基于灰色GM（1,1）预测模型的构建理论,尝试引入缓冲算子来消除瓦斯涌出量原始数据序列所受到的冲击扰动,并利用MATLAB语言编程实现瓦斯涌出量灰色GM（1,1）预测模型程序化运算,选择合理的精度检验方法对预测模型和结果进行检验判断。通过工程实例,证明了引入缓冲算子改进的GM（1,1）模型预测精度和拟合优度更高,可为煤矿企业正确决策提供一定的理论依据。     

Changes in physical features of Glacier No. 1 of the Tianshan Mountains in response to climate change

This study analyzes the changes in glacier zones and snow composition of Glacier No.1 in the Tianshan Mountains of China since 1961,and their possible relations with climate.It is found that precipitation dominated the snow composition and that air temperature and precipitation controlled the distribution of glacier zones,but interannual change in precipitation had a relatively large effect on glacier zones and snow composition during 1963–1981 (P10) and 1963–1989 (P11).However,during 1982–2007 (P20) and 19...     

MCP-1在子痫前期患者胎盘组织及血清中的表达及意义

通过比较单核细胞趋化蛋白-1（MCP-1）在正常孕妇和子痫前期患者胎盘及血清中的表达,探讨MCP-1在子痫前期发病机制中的作用。选取30例正常晚孕妇女、30例轻度子痫前期患者和30例重度子痫前期患者进行研究。采用免疫组织化学S P法检测MCP-1在胎盘组织中的表达;采用酶联免疫吸附法（ELISA）检测血清MCP-1水平。结果：子痫前期患者胎盘组织和血清中MCP-1的表达均高于正常妊娠组,差异有统计学意义（P〈0.01）,且随着病情加重而递增;子痫前期患者胎盘组织MCP-1表达与血清MCP-1水平呈显著正相关（r=0.725,P〈0.01）。结果表明,MCP-1在子痫前期患者胎盘与血清中的表达均升高,提示MCP-1在子痫前期的发生、发展中可能起着重要的作用。     

芳香单氮氧化物与丙烯酸稀土配合物的合成及荧光性质

合成了８种稀土（Ｌａ－Ｔｂ）丙烯酸盐与邻菲罗啉单氮氧化物（ＰｈｅｎＮＯ）的三元固体配合物,通过元素分析确定其组成式为ＲＥ（Ｃ２Ｈ３ＣＯ２）３·（ＰｈｅｎＮＯ）,研究了它们的红外光谱、紫外光谱及荧光光谱,探讨了配体对该配合物荧光性质及稳定性质的影响。     

A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

Summary The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of ¹-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.We thank the National Institute on Drug Abuse for supporting this project by grants DA-02043 and DA-02052 and for supplying all of the cannabinoids. One of us (S.B.) is also the recipient of a Research Scientist Award from NIDA. We are grateful to Kristen Carlson and Thomas Honeyman for helpful suggestions in preparing this report.     

CD1d and natural T cells: how their properties jump-start the immune system

Cellular and humoral immune mechanisms recruited to defend the host from infectious agents depend upon the early immune events triggered by antigen. The cytokine milieu within which the immune response matures is the most important of many factors that govern the nature of the immune response. Natural T cells, whose function is controlled by CD1d molecules, are an early source of cytokines that can bestow type 1 or type 2 differentiative potential upon helper T lymphocytes. This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T cells and how CD1d and natural T cells interact to jump start the immune system. CD1d is postulated to function as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates natural T cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jumpstart the immune system. Received 10 July 2000; received after revision 16 October 2000, accepted 16 November 2000     

Sphingolipids in mammalian cell signalling

Sphingolipids and their metabolites, ceramide, sphingosine and sphingosine-1-phosphate, are involved in a variety of cellular processes including differentiation, cellular senescence, apoptosis and proliferation. Ceramide is the main second messenger, and is produced by sphingomyelinase-induced hydrolysis of sphingomyelin and by de novo synthesis. Many stimuli, e.g. growth factors, cytokines, G protein-coupled receptor agonists and stress (UV irradiation) increase cellular ceramide levels. Sphingomyelin in the plasma membrane is located primarily in the outer (extracellular) leaflet of the bilayer, whilst sphingomyelinases are found at the inner (cytosolic) face and within lysosomes/endosomes. Such cellular compartmentalisation restricts the site of ceramide production and subsequent interaction with target proteins. Glycosphingolipids and sphingomyelin together with cholesterol are major components of specialised membrane microdomains known as lipid rafts, which are involved in receptor aggregation and immune responses. Many signalling molecules, for example Src family tyrosine kinases and glycosylinositolphosphate-anchored proteins, are associated with rafts, and disruption of these domains affects cellular responses such as apoptosis. Sphingosine and sphingosine-1-phosphate derived from ceramide are also signalling molecules. In particular, sphingosine-1-phosphate is involved in proliferation, differentiation and apoptosis. Sphingosine-1-phosphate can act both extracellularly through endothelial-differentiating gene (EDG) family G protein-coupled receptors and intracellularly through direct interactions with target proteins. The importance of sphingolipid signalling in cardiovascular development has been reinforced by recent reports implicating EDG receptors in the regulation of embryonic cardiac and vascular morphogenesis. Received 16 May 2001; received after revision 29 June 2001; accepted 3 July 2001