Functions and pathologies of BiP and its interaction partners

The endoplasmic reticulum (ER) is involved in a variety of essential and interconnected processes in human cells, including protein biogenesis, signal transduction, and calcium homeostasis. The central player in all these processes is the ER-lumenal polypeptide chain binding protein BiP that acts as a molecular chaperone. BiP belongs to the heat shock protein 70 (Hsp70) family and crucially depends on a number of interaction partners, including co-chaperones, nucleotide exchange factors, and signaling molecules. In the course of the last five years, several diseases have been linked to BiP and its interaction partners, such as a group of infectious diseases that are caused by Shigella toxin producing E. coli. Furthermore, the inherited diseases Marinesco-Sj?gren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological characteristics of BiP and its interaction partners. Received 20 November 2008; received after revision 09 December 2008; accepted 12 December 2008     

苏桥储气库群高压、高温介质管道腐蚀控制措施

结合苏桥储气库群特殊工况,从介质温度、系统压力、流速、流态等分析引起管道腐蚀的各种因素,最后总结出一系列较为适宜的腐蚀控制措施。     

不锈钢波纹管失效分析

通过对某合成氨厂冰机冷凝器使用的波纹管宏观分析、成分分析、金相分析、电镜分析,同时结合生产工艺对波纹管失效的原因进行探讨。结果表明:材料中的夹杂物的存在是形成破损通道的主要原因。适当提高不锈钢中的Cr含量,可以提高波纹管的耐蚀性。     

Ostracod fauna of salt Lake Acıgöl (Acı Tuz) (Turkey)

Lakes and wetlands in Mediterranean regions are overexploited and contaminated without sufficient local governmental control. The biodiversity of Salt Lake Ac?göl (Turkey), an internationally recognized ecosystem, is presently endangered by management plans. This study aims to analyse the ostracod community to establish its ecological status as a base for future paleoecological studies using ostracods to reconstruct the recent evolution of this wetland. Samples were collected seasonally and 13 species were recorded. Multivariate classification and ordination statistical methods revealed a major difference between assemblages related to the relative abundance of species tolerant of desiccation vs. species preferring permanent waters. Cyprideis torosa, mainly found in saline, low diversity sites, is a euryhaline species regarded as an indicator of future lake conditions if inappropriate water resource management continues.     

中西方椅子设计比较研究

以中西方文化为基点,分析了文化背景下中西方椅子的功能、造型、材料、装饰差异及形成原因;研究了文化交流背景下中西方椅子设计的相互影响;进而对中国现代椅子的设计创新提出了要求和建议。     

新型LS－101高温缓蚀剂的研制与工业应用

本文研制出一种适用于常减压装置高温运行部位的LS－101高温缓蚀剂，实验室测试结果表明，该药剂的缓蚀率达到97％以上。工业应用结果表明，LS－101有良好的高温缓蚀性能，对抑制常减压装置的高温部位腐蚀具有很好的效果。     

膨润土极限活化量测定方法研究

本文介绍了用工艺试样热湿拉强度、高水湿压强度和膨润土的液性极限来测定膨润土的极限活化量。通过对若干种膨润土极限活化量的测定发现,对同种膨润土,由三种方法测得的极限活化量都基本相同,高水湿压强和液性极限的方法对没有热湿拉强度仪的厂家更为实用.同时还发现各种膨润土的极限活化量并不相同,所以通常活化型砂用膨润土,活化剂加入量固定为膨润土量的4～5%并不都是适宜的.     

球铁热浸渗铝工艺及渗铝球铁耐热性能的研究

本文对球墨铸铁的热浸渗铝工艺和渗铝球铁的耐热性能进行了研究。实验结果表明:采用热浸渗铝工艺可较大幅度地提高球铁的抗氧化和抗生长能力;由于铸铁成分和组织上的特点,其热浸渗铝工艺与低碳钢有所不同。     

聚钛氨烷－钯配合物催化卤代苯双羰基化合成α－酮酰胺的研究

报道了以二氧化硅为担载的聚钛氨烷－钯配合物（Ｔｉ－Ｎ－Ｐｄ）的合成和其对卤代苯双羰基化合成α－酮酰胺反应的催化作用。在一氧化碳压力为３．０ＭＰａ，１００℃下反应６ｈ，碘苯转化率达１００％，双羰化产物（ＰｈＣＯＣＯＮＥｔ２）选择性高于９０％。且催化剂易与反应产物分离和重复使用，经回收使用１０次，催化剂的活性和选择性基本保持不变。     

合金元素对热作模具钢组织与性能的影响

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