粉防己碱逆转人早幼粒白血病HL60耐药细胞对三尖杉酯碱的耐药性

无细胞毒性浓度的粉防己碱（０．５ｍｇ·Ｌ－１），明显地增强三尖杉酯碱对人早幼粒白血病ＨＬ６０耐药细胞的生长抑制作用，降低集落形成率，但对敏感ＨＬ６０细胞没有增强作用。ＤＰＨ荧光标记法测定表明，粉防己碱对细胞膜流动性没有影响；提取经药物作用后的细胞ＤＮＡ，琼脂糖凝胶电泳显示，粉防己碱增加三尖杉酯碱引起的ＨＬ６０耐药细胞ＤＮＡ降解，使细胞以编程方式死亡。结果表明：粉防己碱能逆转人早幼粒白血病ＨＬ６０耐药细胞对三尖杉酯碱的耐药性，值得临床上进一步研究。     

一类高阶迭代边值问题的正解

基于Krasnosel'skii不动点定理考虑了一类四阶迭代边值问题u'(t)=f(t,u(t),u(αu(t))),0≤t≤1,u(0)=u'(0)=u'(1)=u'(1)=0正解的存在性.通过估计解的界,获得了上述边值问题分别存在和不存在正解的几组充分条件.最后给出例子说明了主要结果的可行性.     

桃皮效应:准超疏水高黏附表面(英文)

桃皮表面具有特殊的浸润和黏附性质.本文揭示了桃皮表面主要由长、短2种绒毛组成.其中长绒毛含有较多疏水的蜡质,短绒毛含有较多亲水的多糖基团.正是由于2种绒毛的化学组成和微观结构使得桃皮表面具有准-超疏水、高黏附的性质.桃皮表面的水滴能够维持良好的球形,即使将桃皮倒立放置,水滴也不会滚动,我们将此定义为桃皮效应.通过化学法和物理法改变其表面化学组成和微观形貌,推断出水滴在桃皮表面以Wenzel和Cassie共存态存在,使得水滴与桃皮表面产生较强的相互作用,从而使桃皮表面具有超疏水和高黏附性质.     

带Navier边值条件的(p(x),q(x))-双调和问题的多解性

研究了一类带Navier边值条件的(p(x),q(x))双调和问题的存在性和多解性,利用Ricceri’s三临界点定理,得到问题至少存在3个弱解.     

枯草芽孢杆菌YA-3对番茄早疫病的防治作用

从西洋参种植土壤中分离获得一株具有抗真菌活性的细菌YA-3,杯碟法测定表明,该拮抗菌对13种植物病原真菌均有不同程度的抑制作用,其中对番茄早疫病抑制率达82.2%;YA-3培养滤液可导致番茄早疫病病原菌菌丝畸变、枯萎或者断裂,阻碍菌丝生长,并能够抑制其孢子萌发,抑制率达92.3%以上;利福平抗性标记试验表明,YA-3在番茄叶片上有很强的定殖能力,第26 d仍能检测到该菌;经盆栽试验结果表明,YA-3发酵液可使番茄叶片发病率显著降低,防治效果可达到75.52%;根据其形态、生理生化特性及16S r DNA同源性分析结果,鉴定为枯草芽孢杆菌(Bacillus subtilis)。     

板面为各向异性面的横观各向同性弯曲板的精化理论

在板面为各向同性面的横观各向同性板精化理论的基础上,对板面为各向异性面的横观各向同性板进行了研究,并推导出其精化理论。根据横观各向同性弹性理论和Elliott-Lodge通解,在不作任何预先假设的条件下,获得了由板中面上的位移和转角表示的位移场和应力场,根据Lur’e方法和边界条件获得了板面受横向载荷的精化方程,略去高阶项后获得可直接应用的近似控制微分方程。令所有物理量与x2或x3无关,得出的精化理论分别与横观各向同性梁和各向同性梁的精化理论一致。     

早熟蓝莓早花气象原因分析

针对2021年黔东南部分基地的奥尼尔、夏普蓝等早熟蓝莓出现早花,因遭遇后期持续低温导致近三分之一的花不能坐果.利用蓝莓基地气象自动观测站点逐日气温、降雨、日照资料与蓝莓开花和花后坐果所需气象条件进行对比分析,结果表明:早熟蓝莓在需冷量满足的情况下,当日平均气温连续5 d以上≥12.8℃,即可进入始花期;开花后,如果遇日...     

云南巧家—石屏盆地早震旦世充填序列及构造演化

云南巧家-石屏盆地早震旦世的充填序列可划分为下段冲积扇-大陆人山-砾质辫状河沉积,中段曲流河沉积及上段砂质辨状河沉积。盆地经历了早期断陷、中期拗陷及晚期萎缩回升3个构造演化阶段。     

High-altitude salt lake elevation changes and glacial ablation in Central Tibet, 2000-2010

This research quantifies lake level variations in the Siling Co, Co’e and Bangor Co salt lakes in Central Tibet from 1976 to 2010, and most notably for the 2000-2010 periods. In particular, the effects of different water replenishment modes on the lakes have been analyzed. Here we have provided new evidences for climate warming and accelerated glacial ablation on the Central Tibetan Plateau from 2000 to 2010. Based on fieldwork involving Differential Global Positioning System (DGPS) surveying and Remote Sensing (RS) interpretations of the lake area, we have drawn the following conclusions. (1) From 1976 to 2010, the process of lake level variation in Siling Co can be divided into two stages. From 1976 to 2000, the lake level rose 4.3 m in a steady fashion (from 4530 to 4534.3 m); the rise rate was 0.18 m/a. From 2000 to 2010, the lake level rapidly rose 8.2 m (from 4534.3 to 4542.5 m), with a dramatically higher rise rate of 0.82 m/a. Compared with the rapidly increasing lake level of Siling Co from 2000 to 2010, the fluctuations observed at Co’e and Bangor Co were smooth and inconspicuous. (2) From 1976 to 2009, the lake area of Siling Co experienced a steady-rapid-steady expansion pattern. The lake area of Siling Co increased 656.64 km2 in the 34 years to 2010, a proportional growth of 39.4%. This was particularly significant in the 2000-2010 period, when the lake area of Siling Co increased by 549.77 km2, a proportional growth of 30.6%. (3) According to correlation analysis, the rise in regional temperatures, which has led to the ablation of glaciers, is the main reason for the rapid rise in Siling Co lake levels in the 10 years to 2010. During this period, Siling Co rose approximately 8 m as the direct result of glacial melting. An increase in precipitation in the Siling Co catchment area is the secondary factor. This contrasts with Bangor Co, where the dominant factor in lake level change is the long-term increase in precipitation; here, the increasing temperature is the secondary factor.     

分光光度法测定市售胶囊与针剂中头孢拉定含量

在弱酸性溶液中,头孢拉定能将Fe3+还原为Fe2,利用Fe2+与2,2’-联吡啶形成桔红色配合物在520nm处有最大吸收,从而建立了Fe2+-头孢拉定-2,2’-联吡啶分光光度法测定头孢拉定的新方法.头孢拉定标准溶液浓度在0.20～ 10.0μg/mL范围内与吸光度呈良好线性关系,线性回归方程为A=0.05664c (mg/L)+0.044,表观摩尔吸光系数为1.98×104Lmol-1·cm-1.该法用于市售胶囊与针剂中头孢拉定的含量分析,结果满意.