血管内皮生长因子结合可降解壳聚糖治疗大鼠心肌梗塞的研究

摘要:目的 研 究 血 管 内 皮 生 长 因 子 ( vascular endothelial growth factor, VEGF ) 结 合 可 降 解 壳 聚 糖 ( degradablechitosan,DC)对心肌梗塞大鼠的治疗作用。 方法 将 32 只 SD 大鼠随机分为假手术组、模型组、VEGF 组和 VEGF+ DC 组,每组 8 只。 4 组大鼠均采用结扎冠状动脉左前降支的方法进行造模,其中假手术组只穿线不结扎。 造模后, 向模型组大鼠心肌注射 100 μL 生理盐水,VEGF 组大鼠于同一位置注射同体积 VEGF 溶液,VEGF+DC 组大鼠注射 VEGF+DC 溶液。 造模 4 周 后,对 所 有 实 验 大 鼠 进 行 超 声 心 功 能 检 测,考 察 左 心 室 收 缩 期 及 舒 张 期 前 壁 厚 度( LVAW;s 和 LVAW;d) 、左心室收缩期及舒张期内径( LVID;s 和 LVID;d) 、左心室收缩期及舒张期容积( LV Vol;s 和 LV Vol;d) 、左室射血分数( EF% )及短轴缩短率( FS% ) ,血流动力学考察左室舒张末压( EDP ) 和等容收缩期及 舒张期左心室内压力上升最大速率( + dp / dt 和 - dp / dt) ,计算左心室指数( LVM / BW) 并对心肌进行苏木素-伊红 ( HE)染色观察各组实验大鼠心肌病理变化。 结果 VEGF 组和 VEGF+DC 组大鼠的心肌梗塞均得到有效改善,其 中 VEGF+DC 组的改善作用更加显著。 结论 VEGF 结合 DC 对心肌梗塞大鼠的心功能具有改善作用,具有一定的治疗作用。     

Study on Approach for Computer-Aided Design and Machining of General Cylindrical Cam Using Relative Velocity and Inverse Kinematics

Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa tic transfer equipments. This paper proposes a new approach for the shape design and manufacturing of the cylindrical cam. The design approach uses the relative velocity concept and the manufacturing approach uses the inverse kinematics concept. For the shape desig n, the contact points betw...     

凸轮-连杆组合机构设计系统

将计算机辅助设计技术、网络技术与机构设计相结合,以组合机构的尺寸综合理论为基础,以机构最小尺寸为优化目标,采用Java作为开发语言,应用模块化的面向对象的设计方法,研制开发了凸轮-连杆组合机构网上设计系统.     

基于知识融合的汽车覆盖件模具设计方法研究

针对产品设计过程中,分散异构知识融合不足导致知识检索准确性不高、知识重用效率低等问题,提出一种知识融合模型.利用知识需求模型传递知识需求信息,采用知识元对各类异构知识进行统一表示,通过概念本体对语义概念进行有序组织,与知识元之间形成映射关系.通过语义距离计算获取候选知识元集,并采用基于贝叶斯和遗传算法的知识融合方法将分散的关联知识元融合成知识单元,实现知识重用.以覆盖件模具结构设计为案例验证了所提出方法的可行性和有效性.     

Entransy dissipation minimization for optimization of heat exchanger design

In this paper,by taking the water-water balanced counterflow heat exchanger as an example,the entransy dissipation theory is applied to optimizing the design of heat exchangers.Under certain conditions,the optimal duct aspect ratio is determined analytically.When the heat transfer area or the duct volume is fixed,analytical expressions of the optimal mass velocity and the minimal entransy dissipation rate are obtained.These results show that to reduce the irreversible dissipation in heat exchangers,the heat exchange area should be enlarged as much as possible,while the mass velocity should be reduced as low as possible.     

Optimization model of a structural simulation design for a CICC

The engineering design of a Cable-In-Conduit Conductor (CICC) is complicated. A model for the optimal design of a CICC based on conductor stability, AC loss and strain is proposed. The model considers the critical current density as a function of applied strain. A mathematical programming method that minimizes the AC loss of the CICC is established to yield an optimal design for the CICC structure. The optimized structure and related performance agree well with the engineering design values used for the KSTAR project.     

Sequence similarity analysis of non-self CTL epitopes and mouse proteins using sequence alignment

This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.     

蜂窝夹芯减振板结构设计的力学参数计算

从力学性能和减振性两方面分析了用瞬间液相扩散复合法得到的蜂窝板的蜂窝结构,确定了面板厚度、芯材厚度、蜂窝格边长、蜂窝格壁厚4个结构参数作为设计变量,以剪切强度、弯曲强度、抗弯刚度、临界屈曲载荷、固有频率、质量6个性能参数为目标函数进行优化,并对优化结果进行了实验研究. 结果表明,优化设计的蜂窝板的力学性能及减振性能优于对比板,实验值与计算值基本相符.     

热分析技术在电子设备热设计中的应用

在传热学理论的基础上,介绍了Icepak的特点及求解过程.以笔记本电脑为例,利用Icepak软件对电子设备的计算域进行仿真,并对其进行了热分析,讨论了散热方式的选择和具体的热设计,最终使其满足温度控制的要求.     

大工程背景下机械设计基础课程教学改革与实践

对目前高等学校机械设计基础课程教学中存在的问题进行了分析,并对该门课程的教学内容、教学方法、教学手段、实践环节、考核方式等进行了改革实践,为进一步培养学生工程实践能力和创新设计能力奠定了基础.