基于复杂网络的禽流感病毒传播

基于复杂网络理论,研究了禽流感病毒的传播机制.根据实证数据分析,建立了一个禽流感病毒传播的小世界网络模型.通过对病毒传播中个体的接触程度、传染概率、潜伏期等因素研究,分析了现在对禽流感病毒预防措施的有效性.最后,通过对世界卫生组织公布的各地禽流感病毒爆发的数据进行统计,说明了用小世界网络模型模拟禽流感病毒传播的可行性.     

Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B

Small HERC proteins are defined by the presence of one RCC1-like domain and a HECT domain. Having evolved out of one common ancestor, the four members of the family exhibit a high degree of homology in genomic organization and amino acid sequence, thus it seems possible that they might accomplish similar functions. Here we show that small HERC proteins interact with each other and localize to the same cellular structures, which we identify as late endosomes and lysosomes. We demonstrate interaction of HERC3 with the ubiquitin-like proteins hPLIC-1 and hPLIC-2 and we establish interaction of HERC5 with the metastasis suppressor Nm23B. While hPLIC proteins are not ubiquitinated by HERC3, HERC5 plays an important role in ubiquitination of Nm23B. In summary, although small HERC proteins are highly homologous showing the same subcellular distribution, they undergo different molecular interactions.     

ERK activation by Ca2+ ionophores depends on Ca2+ entry in lymphocytes but not in platelets, and does not conduct membrane scrambling

Rapid Ca²⁺-dependent phospholipid (PL) reorganization (scrambling) at the plasma membrane is a mechanism common to hematopoietic cells exposing procoagulant phosphatidylserine (PS). The aim of this research was to determine whether activation of the extracellular signal-regulated kinase (ERK) pathway was required for PL scrambling, based on a single report analyzing both responses induced by Ca²⁺ ionophores in megakaryoblastic HEL cells. Ca²⁺ ionophore-stimulated ERK phosphorylation was induced in platelets without external Ca²⁺, whereas exogenous Ca²⁺ entry was crucial for ERK activation in Jurkat T cells. In both cells, membrane scrambling only occurred following Ca²⁺ entry and was not blocked by inhibiting ERK phosphorylation. Furthermore, ERK proteins are strongly phosphorylated in transformed B lymphoblastic cell lines, which do not expose PS in their resting state. Overall, the data demonstrated that ERK activation and membrane scrambling are independent mechanisms. A. Arachiche, I. Badirou: These authors contributed equally to this work. Received 18 June 2008; received after revision 24 September 2008; accepted 1 October 2008     

基于DS18B20测温的ARM温度采集系统研究

通过研究实现了以ARM为核心的温度采集系统,采用数字温度计芯片DS18B20构成测温单元,设计了DSl8B20与ARM连线图,并介绍了如何实现温度采集以及与PC机间的数据通讯。PC机可把接收到的ARM采集到的温度数据进行整理并显示,具有一定的实用价值。     

Functional interactions of protein kinase A and C in signalling networks: a recapitulation

On the basis of evidence collected from the literature, we propose a general model by which protein kinase (PK) A and the different PKC isoforms can inversely affect cell growth. Molecular switches, which are able to direct the signal towards antiproliferative or mitogenic pathways, are the different isoforms of Raf and PKC. Conflicting data are also reported and discussed in an attempt to reconcile them. Received 10 November 2005; received after revision 28 December 2005; accepted 3 January 2006     

基于OpenGL的B样条曲线的分类及实现

通过对B样条曲线按节点进行分类,使用OpenGL中的NURBS接口函数,完成了各类B样条曲线的实现．     

BBM—likeB（2，2）方程的圈波及周期圈波解

应用微分方程动力系统理论研究BBM—likeB（2，2）方程的圈波及周期圈波解。在某些参数条件下给出该方程平面系统的相图，根据相图找到圈波及周期圈波解的存在条件，并求出了这两种解的参数形式表达式。通过软件Mathematica模拟了这两种解的平面波形图。     

基于B+树的BPEL流程异常处理机制研究

Web服务组合具有松耦合、自治性的特点,BPEL规范中的异常处理机制也不完善,于是BPEL流程中的异常处理方法是研究的一个主要问题。针对该问题,在流程运行阶段处理异常的一些通用的策略的基础上,提出了基于B+树的等价服务替换算法,分别阐述了BPEL中同步和异步调用Web服务产生异常的情况,最后构架了一个异常处理的系统框架原型。     

TiO2空心微球的制备及其在模拟太阳光下光催化降解罗丹明B活性

以钛酸丁酯为反应原料、油胺为模板剂,采用溶剂热法制备了TiO2空心微球.通过XRD、SEM、TEM、HR-TEM、N2吸附-脱附实验及FT-IR对其晶体结构、形貌、表面性质及比表面积进行了表征.在模拟太阳光下研究了TiO2对罗丹明B的光催化降解活性,并与商品TiO2(P25)的活性相比较.结果表明,空心微球为纯相锐钛矿型TiO2,球的直径处于2-5 μm之间,构成微球的初级粒子的平均粒径为10.7 nm,BET比表面积为42.95 m2/g.所制备的TiO2空心微球在2h内对罗丹明B溶液的光降解率达72％.因粒径较大而使其不易团聚,且极易回收,有利于实际应用.