Neuroreplacement therapy and stem cell biology under disease conditions

Recent advances in stem cell technology are expanding our ability to replace a variety of cells throughout the body. In the past, neurological diseases caused by the degeneration of neuronal cells were considered incurable because of a long-held 'truism'; neurons do not regenerate during adulthood. However, this statement has been challenged, and we have now found much evidence that the brain is indeed capable of regenerating neurons after maturing. Based on this new concept, researchers have shown neural differentiation of stem cells and recovery of function following transplantation of these cells into the brain. These results may promise a bright future for clinical applications of stem cell strategies in neurological diseases; however, we must consider the pathophysiological environments of individual diseases that may affect stem cell biology. Before we begin to develop clinical applications, we must consider environmental factors that have not been discussed in the current preclinical studies. Here, we study cases of Alzheimer's disease and schizophrenia and discuss the effects of environmental factors under disease conditions.Received 15 January 2003; received after revision 7 April 2003; accepted 8 April 2003     

(k+1)-连通无K_(1,r)-图是Hamilton-连通的两个充分条件

一个图若不含与Ｋ１,ｒ（ｒ３）同构的导出子图,则称它为无Ｋ１,ｒ－图．本文将运用Ｔ－插点方法,通过对图的独立集的邻域交的研究,给出（ｋ＋１）－连通无Ｋ１,ｒ－图（ｒ４）是Ｈａｍｉｌｔｏｎ－连通的两个充分条件．     

Jacobi Inversion Problem for the Modified Jaulent-Miodek Hierarchy

IntroductionTheseparabilityoftheHamilton-Jacobiequa-tionandtheclassicalPoissonstructureforafinite-dimensionalintegrableHamiltoniansystem(FDIHS)playsanimportantroleinconstructingsolutionsandintheunderstandingofthecompleteintegrabilityofanFDIHS[1,2].Recently,muchin-teresthasdevelopedinthestudyofseparationofvariablesforcompletelyintegrableHamiltoniansystems[3-12].ForsomeFDIHSs,theLaxmatrixandr-matrixprovideaneffectivewaytoinvestigatetheseparationofvariables.Ithasbeenshownthateachequation…     

关于Ramsey数r(3,q)下界公式的一点注记

本文证明了一类特殊的循环图是（3,q）—图,从而得到当q≥9且q是奇数时,r（3,q）≥8（q—8） 2     

Substance P-induced fibrinolysis in the forearm of healthy humans

Physiological saline with or without substance P (50 ng/ml) was infused into the humeral artery in 6 healthy males. Indices of fibrinolytic activity (whole blood diluted lysis time, euglobulin lysis time, lysis areas in non-heated fibrin plates produced by plasma or euglobulin precipitate, plasminogen plasma levels, ₂-macroglobulin, Cl-inhibitor, and ₂-antiplasmin) were evaluated in the homolateral antecubital vein before and after 5 min of substance P or saline infusion. After substance P the fibrinolytic activity increased, as can be seen from the shortening of lysis times (p<0.01) and enlargement of the lysis areas (p<0.01). A reduction of plasminogen plasma levels (p<0.01), associated with a decrease in ₂-anitplasmin (p<0.01), was also found. Alpha₂-macroglobulin and Cl-inhibitor were instead unaltered by the peptide. The saline infusion, on the other hand, was unable to modify any of the examined indices. We concluded that exogenous substance P given intra-arterially increases fibrinolytic activity in locally-sampled venous blood through a mechanism which remains to be elucidated.     

关于一般Liénard系统解的唯一性问题的注记

研究dxdt=h(y)-F(x),dydt=-g(x)关于初值问题解的唯一性问题,给出了如下定理:定理A,设系统(2)仅有有限奇点,若F(x)和g(x)在R上连续,h(y)在R上具有连续导数且h′(y)>0,则系统(2)满足初始条件x(t0)=x0,y(t0)=y0的解唯一.其中M0(x0,y0)不为奇点.同时,当h(y)为严格下凸函数时,给出了类似的定理B.     

Sech~2(βr)型势阱中相对论粒子的束缚态

在Sech2(βr)型标量势与矢量势相等的条件下,严格求解了s波的Klein-Gordon方程和Dirac方程,给出了标量粒子和旋量粒子的束缚态波函数以及能谱所满足的方程。     

L-smooth半预开集与L-smooth半预不定映射

以文献[5]为基础，在L—smooth拓扑空间中定义了r-半预开集、r-半预闭集、r-半预内部、r-半预闭包，研究了它们的一些基本性质；同时，引入了L—smooth半预不定映射、L-smooth半预不定开映射、L—smooth半预不定闭映射及L—smooth半预不定同构映射的概念，给出了它们的等价刻画，并系统的讨论了它们之间的关系，推广了已有的结果。     

Electroluminescence and photoluminescence of dioctylfluorene and 4,7-dithien-2-yl-2,1,3-benzothiadiazole copolymers

Dioctylfluorene (DOF) and 4,7-dithien-2-yl- 2,1,3-benzothiadiazole (DB T) copolymers synthesized in our lab with different compositions of DBT (1%, 5%, 15% and 25%) were utilized to fabricate bilayered light emitting diodes. Extern al quantum efficiency (QE) of the diode fabricated from the copolymer with 15% D BT content reaches 1.4% (ph/el), over 1.0 cd/A in luminance efficiency at the driving voltage of 4.2 V. The highest luminance can reach 3780 cd/m2 at 8.2 V. Devices emit a saturated red light centered at 675 nm with chromaticity coordinate changed from x = 0.66, y = 0.32 for PDOF-DBT1 (1% DBT) to x = 0.70, y = 0.28 for PDOF-DBT25 (25% DBT).     

涌泉现象中的水锤数值模拟

介绍了大型运载火箭推进剂管道系统在地面待命期间，由于涌泉现象引起的两相流水锤，采用蒸气-蒸发冷凝离散模型来模拟两相流水锤现象，利用特征线方法进行计算求解，计算结果为火箭低温推进剂系统的安全性分析提供了基础。