球面谐和函数Y_(lm)(θ,φ)的降阶表达式

本文给出连带勒让特函数P_1(x)的二个新递推公式,由它只需经简单的代数运算就可从一阶连带勒让特函数P_1~0(x)与P_1~1(x)逐次求得任意高阶连带勒让特函数。并在这两个新公式基础上导得球面谐和函数Y_l(θ,φ)的降阶表达式。     

香花岭锡多金属矿床中伴生银的赋存状态研究

采用多种测试手段,查明了香花岭锡多金属矿床硫化矿物中的伴生银主要呈独立矿物形式存在,部分呈类质同象(晶格银)和显微分散相状态存在。文中总结了银的富集变化规律,分析了银富集的主要矿化阶段,明确指出了伴生银的有望地段和找矿标志。为伴生银矿床的找矿评价和综合利用提供了地质及理论依据。     

基于可拓理论的供应商选择

结合供应链环境下供应商选择的实际需要，利用物元模型和可拓集合理论，建立了能够反映供应商选择内在规律的关联函数和可拓评判模型，并通过实例验证了模型的有效性。     

Si-1基因在肿瘤中的缺失和突变状况初步研究

 通过对Si-1基因6,14和15号外显子区段的PCR扩增,分析了Si-1基因在116例恶性肿瘤组织、1例良性肿瘤和21例非肿瘤组织的缺失和突变.发现恶性肿瘤中有7例缺失,8例有内含子突变;良性肿瘤中没有缺失和突变;非肿瘤组织中没有缺失,1例有内含子突变.脑肿瘤的缺失率最高,达到57.1%,内含子突变率42.9%;肝癌的缺失率达15%,内含子突变率26.7%.上述结果表明,Si-1基因在脑肿瘤和肝癌组织中有较高的缺失和内含子突变,显示该基因有可能是这2种肿瘤的易感基因.     

The growth dynamics of tumor subject to both immune surveillance and external therapy intervention

Considering the growth of tumor cells modeled by an enzyme dynamic process under an immune surveillance, we studied in anti-tumor immunotherapy the single-variable growth dynamics of tumor cells subject to a multiplicative noise and an external therapy intervention simultaneously. The law of tumor growth of the above anti-tumor immunotherapy model was revealed through numerical simula- tions to the relevant stochastic dynamic differential equation. Two simulative parameters of therapy, i.e., therapy intensity and therapy duty-cycle, were introduced to characterize a treatment process similar to a tumor clinic therapy. There exists a critical therapy boundary which, in an expo- nent-decaying form, divides the parameter region of therapy into an invalid and a valid treatment zone, respectively. A greater critical therapy duty-cycle is necessary to achieve a valid treatment for a lower therapy intensity while the critical therapy intensity decreases accordingly with an enhancing immunity. A primary clinic observation of the patients with the typical non-hodgekin’s lymphoma was carried out, and there appears a basic agreement between clinic observations and dynamic simulations.     

法律术语数据库在自然语言检索中的应用研究

介绍了术语和术语数据库,分析了术语数据库在自然语言检索中的应用机制,探讨了基于法律术语数据库的自动标引。     

针吸细胞学检查在乳腺癌诊断中的意义

目的：观察乳腺肿物针吸细胞学诊断与组织病理学检查的符合率。方法：对166例乳腺肿物吸出组织，经巴氏（Papanicolaou)染色，参照分级标准及良、恶性肿瘤组织细胞的形态进行了显微镜下早期诊断。结果：166例针吸细胞学诊断与组织病理检查诊断符合率为89.76%、灵敏度84．81％、特异度94．25％。其中良性肿瘤69例，假阴性12例（12．77％）；乳腺癌和高度怀疑有癌特征的97例，假阳性5例（6.94%)。结论：乳腺针吸细胞学检查在乳腺肿物的临床诊断中具有准确、可靠、安全、经济等重点意义，可以作为乳腺癌诊断的重要手段。     

MRI与CT对恶性胸膜间皮瘤的诊断价值比较

目的：探讨、比较MRI和CT在恶性胸膜间皮瘤临床诊断中的意义。方法：25例经病理组织学或细胞学证实的恶性胸膜间皮瘤患者，术前均进行了MRI和CT检查；比较分析其影像学表现特点及其临床意义。结果：MBI除了对肿瘤内钙化的显示率低于CT外，对恶性胸膜间皮瘤形态学的观察普遍优于或等于CT，尤其对叶间胸膜及横膈膜增厚的显示、肿块侵犯胸壁或膈肌以及肺门或纵隔淋巴结构的显示优于CT。恶性胸膜间皮瘤在T1WI上呈低信号或等信号，而在T2WI及增强T1WI上绝大部分呈高信号。结论：与CT比较，MRI对恶性胸膜间皮瘤的TNM分期以及治疗方案的制订更具指导意义。     

Strategy against micrometastasis of epithelial cancer: Detection and elimination

Tumor metastasis is generally agreed to be the major cause of cancer death. Over the last few years, studies of new diagnosis techniques and tumor immunotherapy have made great progress. Recent clinical studies on the occult metastases of breast, lung and colorectal cancer all suggested that the detection of micrometastases in bone marrow is prognostically important and provides substantial evidence of tumor dissemination. On the other hand, two kinds of the mAb-based immunotherapy have been approved for the treatment against epithelial cancer. Monoclonal antibody (mAb) 17-1A for colorectal carcinomas and mAb herceptin for breast cancer both have produced good curative effects. Potential therapeutics based on some antibodies with prominent antitumor activity also has shown obvious clinical effect. These studies indicate that detection of micrometastasis in circulatory system and immunotherapy by eliminating metastatic malignant cells suggested a new strategy against the metastatic cancer.     

Molecular Cloning of a Novel Bovine Homologue of the Drosophila Tumor Suppressor Gene,Lats

Pervious studies demonstrate that lats,also known as warts,is a tumor suppressor gene in Drosophila^[1,2],Mutations of lats lead to an increase in cell number and organ size in Drosophila,indicating lats may be involved in organ size control.Furthermore,the high conservation of sequence and tumor suppression functioin of lats between Drosophila and human suggests that it may be also involved in organ size control of higher animals^[3],So here we isolated the bovine homologue of Drosophila lats.Sequence analysis indicates the bovine LATS1 to be very similar to other lats proteins.