BNCT物理剂量Monte Carlo程序系统——MCDB及算法

硼中子俘获治疗(BNCT,boron neutron capture therapy)规划软件系统MCDB(Monte Carlo dosimetry inbrain),包括医学前处理、Monte Carlo物理剂量计算和后处理。采用中心点方法确定网格的材料和密度,并自动生成Monte Carlo输入文件。MCDB借鉴并发展了一套网格几何下的快速粒子径迹算法,取得了与MCNP程序一致的剂量计算结果,计算速度较MCNP程序提高2.7~3.5倍。MCDB可进行并行计算,具有线性加速比,能够满足BNCT临床对计算时间和精度的要求。     

阿是穴在临床中的运用

中医的腧穴是精妙而神奇的，而阿是穴作为腧穴的一个重要组成部分，以其无固定部位，无具体名称，灵活性强、疗效显著而得到许多医者的重视。以中医经筋为整体，结合现代解剖学知识，根据肌肉的分布，附着部位，寻找这类阿是穴是行之有效的。笔者在临床中根据刺激阿是穴患者的感应不同及分布与意义的不同将阿是穴分为三类：痛舒阿是穴、痛显阿是穴、痛止阿是穴，在临床上能够准确找到这些阿是穴并灵活运用，对提高推合疗效有着十分重要的意义。     

新生期注射谷氨酸单钠对大鼠其脑钙结合素表达的影响

为探讨谷氨酸单钠（monosodium glutamate,MSG）对脑钙结合素（calbindin-28kD,CB）表达的影响，选用新生SD大鼠29只，分为实验组和对照组，实验组设3g/kg和1g/kg2个剂量组，生后第3－9天经腹腔注射MSG，对照组设实验对照（注射生理盐水12mL/kg）和空白对照，满10周龄时4％甲醛灌注固定，取脑做冰冻冠状切片进行钙结合素的免疫组化反应。计算各组大鼠丘脑、下丘脑、海马及大脑基底核算脑区钙结合素阳性神经元数量。发现钙结合素能神经元分布数量具有脑区差异，且新生期注射谷氨酸单钠可使成年后某些核团的钙结合素阳性神经元增多，表明钙纱能神经元可抗谷氨酸神经毒性。     

脑活动的自组织特征研究

大脑的活动规律是神经科学研究的重点和难点之一，揭示脑的工作原理将有助于真正发现自我，大脑是一个高度的自组织系统，其活动有许多固有特征，相应有许多生物物理解释模型，从不同方面刻画了脑功能，建立一个自组织模型，分析表明该模型可以从神经元活动的共性上来解译脑活动的某些一般规律。     

Construction of human and mouse brain cDNA libraries and isolation of full-length cDNAs

cDNA libraries from aborted human 3-month fetal brain,adult rat and mouse brain were constructed by using a yZAP express cDNA library construction kin.Low molecular weight fragments of the second strand cDNASA were removed by flowing through the Sepharose CL-4B column and the frractionated long,Middle,Short fragments and the combined fragments weire respectively inserted into clone vectors to construct the cDNA libraries of the brain of human 3-month fetus.The 5'ends of 1200 clones from each of human fetal brain cDNA libraries were sequenced.A total of 894 ESTs were obtained and some full-length clones were squenced.By andalyaing the se-quences,12 novel full-length cDNAs were obtained.     

嗅神经鞘细胞移植恢复大鼠损伤脊髓的功能

为探讨嗅神经鞘细胞移植恢复大鼠损伤脊髓的功能 ,将成年大鼠分为脊髓半切洞损伤组 (A组 )和脊髓半切洞损伤 嗅神经鞘细胞移植组 (B)组 ,手术后应用联合行为评分 (CBS)感觉诱发电位 (SEP)和运动诱发电位 (MEP)检查 ,测定脊髓功能恢复情况 .结果 2组CBS得分 ,A组 >B组 ,SEP和MEP潜峰时均A组 >B组 ,统计学分析均有显著性差异 (P <0 0 5 ) .表明移植嗅神经鞘细胞能恢复损伤脊髓的功能     

激素治疗急性脊髓损伤的研究进展

综述了激素治疗急性脊髓损伤方面的研究进展 ,内容涉及到其基础研究和临床应用。     

Human slow wave sleep: A review and appraisal of recent findings,with implications for sleep functions,and psychiatric illness

Recent findings concerning human slow wave sleep (hSWS-stages 3+4; delta EEG activity) are critically reviewed. Areas covered include the significance of the first hSWS cycle; hSWS in extended sleep; relationship between hSWS, prior wakefulness and sleep loss; hSWS influence on sleep length; problems with hSWS deprivation; influence of the circadian rhythm; individual differences in hSWS, especially, age, gender and constitutional variables such as physical fitness and body composition. Transient increases in hSWS can be produced by increasing both the quality and quantity of prior wakefulness, with an underlying mechanism perhaps relating to the waking level of brain metabolism. Whilst there may also be thermoregulatory influences on hSWS, hypotheses that energy conservation and brain cooling are major roles for hSWS are debatable. hSWS seems to offer some form of cerebral recovery, with the prefrontal cortex being particularly implicated. The hSWS characteristics of certain forms of major psychiatric disorders may well endorse this prefrontal link.     

马尾松种源耐寒性的地理变异

对在南京地区的马尾松49个种源试验9年生林分遭受-15℃低温后的冻害调查结果表明,不同种源间耐寒性(冻害)变异极显著。种源冻害表现出从西南向东北逐步减轻;同纬度自西向东明显减轻的倾群地理变异模式。影响冻害的地理、气候因子主要有经度(负相关)、一月均温(正相关)和海拔高度(负相关)。冻害程度与高、径生长呈正相关,与冠幅、开花指数呈负相关。通过典范相关分析和聚类分析,将49个种源按冻害地理变异分成3个类群。     

几个大白菜品种农艺和品质性状及抗病和抗冻能力的比较研究

对5个大白菜品种在4个试验点进行田间试验,重点比较了品种81—5和青杂3号的农艺、品质性状和抗病、抗冻能力。品种81—5苗期生长势、成株紧实度、单株重及亩产量几项性状均明显优越;品质性状总体上看也比较好,表现是含水量和纤维素含量低、蛋白质总量和维生素C及糖分含量高,但游离氨基酸和人体必需的8种蛋白质氨基酸含量较低;对软腐病等主要病害的抗性、耐贮性和抗冻能力均较强,原生质体对冻害损伤的抵抗力较品种青杂3号高40％以上。