阻塞性睡眠呼吸暂停综合征患者软腭射频消融治疗临床研究

应用低温射频技术对47例阻塞性睡眠呼吸暂停综合征患者局麻下行悬雍垂、软腭消融术治疗,分别于术前和术后行多导睡眠图等检查,比较软腭长度、悬雍垂长度、鼾声评级及嗜睡程度评分,观察术中、后的主要反应.结果,47例患者顺利接受全程治疗.随访1个月,临床症状好转,嗜睡评分、鼾声指数明显降低(P<0.05),软腭及悬雍垂缩短(P<0.05).多导睡眠图检查示:1期睡眠减少、快眼动睡眠增加,醒觉次数减少,呼吸暂停低通气指数(AHI)由每小时(34.6±9.9)次减少至每小时(15.4±6.9)次(P<0.05),最低血氧饱和度(SpO2)由(70.6%±9.0%)升高到(80.6%±12.1%)(P<0.05).研究表明低温射频消融术是一项最新的微创、安全的治疗方法,能够有效治疗轻、中度阻塞性睡眠呼吸暂停综合征.     

再论"江枫渔火对愁眠"--与姚振武先生商榷

语法规则往往因文体而异,诗词语法程度远不如散文严格,因而不能用散文语法来规范诗词.对张继<枫桥夜泊>"江枫渔火对愁眠"一句,根据<全唐诗>中的"愁眠"用例以及诗歌用语的特点,并非只可解读为"江枫渔火对着愁眠的人",还可作两种解释对着江枫渔火怀着愁绪而眠;愁人对着江枫渔火而眠.     

Protein misfolding and disease: the case of prion disorders

Recent findings strongly support the hypothesis that diverse human disorders, including the most common neurodegenerative diseases, arise from misfolding and aggregation of an underlying protein. Despite the good evidence for the involvement of protein misfolding in disease pathogenesis, the mechanism by which protein conformational changes participate in the disease is still unclear. Among the best-studied diseases of this group are the transmissible spongiform encephalopathies or prion-related disorders, in which misfolding of the normal prion protein plays a key role in the disease. In this article we review recent data on the link between prion protein misfolding and the pathogensis of spongiform encephalopathies. Received 15 July 2002; received after revision 19 August 2002; accepted 23 August 2002 RID="*" ID="*"Corresponding author.     

试论宋元明初江西朱子学发展的若干特性

朱子与江西渊源甚深,说江西是朱子学发展的最重要地区亦不为过。在历经宋元明初数百年的发展历程中,地域性与家族性是江西朱子学流延传布的最显著的特征,其他诸如延续创造性、批判融合性、超越阶层性等,无不是这一特点在时间与空间方面、纵向与横向方面的延伸,而且这种地域性、家族性背后隐藏了江西士子接受与传播朱子学的特定的行动模式。     

幼儿睡眠、活动时间对身体指数的影响

身体指数包括QI、RI、BMI,幼儿睡眠、活动时间是影响身体指数的重要因素、利用回归分析按性别和年龄考察了幼儿睡眠、活动时间对幼儿身体指数的影响,得出如下结论：（1）睡眠时间是影响幼儿生长发育的主要因素之一;（2）适当的户内外活动有利于幼儿生长发育;（3）五岁女幼儿的身体指数主要受睡眠时间和户内活动时间的影响．     

无线传感器网络能量敏感路由算法的研究与实现

分析了典型无线传感器网络路由算法的基础上,提出了路由算法的目标,并设计了能量敏感的路由算法,以节省能量消耗达到延长整个网络生命周期的目的.该路由算法由4个模块组成:分簇模块、簇头选举模块、休眠状态模块和簇间路由模块组成.在实验室提供的实验床基础上,实现了路由算法的原型,并对算法进行了有效的验证.     

休眠机制下环状簇头协议

环状分层路由协议(RHR),解决了传统分层协议下簇头容易失效、簇头与Sink节点单跳传输耗能过大、传感器网络对簇头的依赖性过强等问题。但经过研究发现RHR环状协议在数据传输过程中,由于大量节点长时间处在空闲监听状态,导致过多的能量浪费和节点的过早死亡。已经证实,节点在空闲监听状态和接收状态耗能接近,所以节点在空闲监听状态下的耗能不容忽视,而避免空闲监听的有效手段就是在没有业务的情况下最大限度地关闭收/发信机。文章基于RHR协议引入休眠机制,提出了一种改进的环状分层路由协议(S-RHR),以达到减少监听能量消耗的目的。经过验证,这种协议在高密度的无线传感器网络中能够更加有效的降低节点耗能,延长网络的生存时间。     

对高中教师睡眠状况的调查研究

本文通过对高中教师睡眠障碍的测试,了解到目前高中教师的睡眠问题带有普遍性。研究结果还表明,高中教师睡眠障碍的程度明显地高于全国常模;随着教师年龄的增长,其睡眠障碍也越来越严重;女性教师的睡眠障碍比男教师更为严重。     

Consortium for the Human Information and Neurocognitive Endophenotype （CHINE） in mainland China： An example from neurological soft signs for neuropsychiatric disorders

Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in mainland China. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in mainland China. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium.     

基于粒子群优化-支持向量机的睡眠呼吸暂停检测

睡眠呼吸暂停(sleep apnea, SA)是一种睡眠障碍疾病,严重影响睡眠质量和身体健康。为降低睡眠呼吸障碍检测的复杂度并提高准确率,提出了一种粒子群优化-支持向量机(particle swarm optimization-support vector machine, PSO-SVM)方法,通过心电信号实现对SA的准确检测。首先,将心电信号分段,并从中提取心率变异性;其次,实现特征提取与选择,包含心电信号RR间期的均值、标准差、均值标准差、差值均方的平方、心率变异性的信号总功率、低频段功率、高频段功率、瞬时中位频率、边际谱熵和能量谱熵等;最后,通过PSO-SVM分类算法进行睡眠呼吸暂停检测。结果表明,筛选10个特征对SA进行检测,利用Apnea-ECG数据库通过PSO-SVM的检测准确率为94.0%,提升了现有方法的检测性能。