TLR9，先天免疫中重要的抗微生物受体

先天免疫系统是宿主抵御外来微生物入侵的第一道防线，TLR9是先天免疫系统中识别细菌和病毒CpGDNA的主要受体。TLR9信号转导利用MyD88依赖途径．在IRAK-4、IRAK-1、TRAF6和TAKl等关键信号蛋白的协同作用下．激活NF-KB和MAP途径，诱导产生一系列促炎细胞因子和趋化因子，最终引起Thl样炎症反应。TLR9除了有抗感染作用，还与自身免疫紊乱和一些恶性肿瘤发生相关。研究TLR9能帮助了解相关疾病发病机理及寻求预防和治疗的手段。     

基于人工免疫的故障诊断模型及其应用

提出了一种基于免疫原理的故障检测及诊断系统模型. 通过对检测对象正常工作状态下获得的自己模式串的阴性选择,随机产生初始检测器;利用基于人工免疫的进化学习机制,实现对检测对象异常工作状态下获得的非己模式串进行学习和记忆;利用进化学习结果和系统故障信息库知识,区分和标记不同故障在状态空间上对应的区域. 将抗原学习过程中抗体集合变异所产生的各代抗体集合看作随机序列,给出了序列的收敛条件及证明,证明了所提出的动态免疫进化学习算法是概率弱收敛. 应用于机床齿轮箱故障检测和诊断问题的实验结果表明了所提出方法的有效性.     

过度训练动物模型的建立及过度训练状态下大鼠肠粘膜病理性变化的研究

为阐明过度训练状态下肠粘膜超微结构和免疫的病理性变化及其发生机制,采用建立一般训练和过度训练大鼠模型,应用形态学手段和分子生化技术,结合免疫组化和图像分析方法,对训练后两组大鼠肠道粘膜的超微结构、脂质过氧化反应产物丙二醛（MDA）、还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和粘膜IgA的产生及含量作定位和定量研究.结果表明,第4周末,一般训练组和过度训练组大鼠肠道粘膜的超微结构、MDA和GSH含量、SOD活性和粘膜IgA水平未见异常改变（p>0.05）.但是第8周末过度训练组电境下见肠道粘膜超微结构明显改变,MDA含量明显升高,GSH含量和SOD活性明显降低;第8周末,IgA浆细胞计数及其平均吸光度,以及粘液IgA水平均显著低于对照组（p<0.01）.结果提示过度训练可以引起肠道粘膜超微结构和IgA屏障结构改变,这些改变可能与肠粘膜自由基损伤有关.     

基于用户行为的Non-self集的构造方法

通过对计算机免疫系统及入侵检测方法的探讨,提出了一种基于用户行为的非我(Non-self)集的构造和演化方法,采用数据挖掘的思想并提出了相应的算法,本系统可以发现入侵并可实时地通知用户入侵的类型及种类.     

一种基于肤色和脸部特征的人脸检测方法

针对人脸检测问题中快速性与准确性难以同时满足的情况,提出了一种将肤色和脸部特征相结合的方法来检测人脸。由于通过基于肤色的算法能快速定位出人脸大致位置,因而检测速度能达到实时的要求;同时利用脸部特征进一步细检,可保证检测的精确性。     

Sperm competition, immunity, selfish genes and cancer

Sperm competition is widespread and has played an important role in shaping male reproductive characters such as testis size and numbers of sperm produced, and this is reflected in the rapid evolution of many reproductive genes. Additionally, sperm competition has been implicated in the rapid evolution of seminal fluids. However, our understanding of the molecular basis of many traits thought to be important in sperm competition is rudimentary. Furthermore, links between sperm competition and a range of issues not directly related to reproduction are only just beginning to be explored. These include associations between sperm competition and selfish genes, immunity and diseases such as cancer.We briefly review these topics and suggest areas we consider worthy of additional research.     

Chitotriosidase: the yin and yang

The enzyme chitotriosidase (ChT), the human analogue of chitinases from non-vertebrate species, is one of the most abundant and indicative proteins secreted by activated macrophages. Its enzymatic activity is elevated in serum of patients suffering from Gaucher’s disease type 1 and in some other inherited lysosomal storage disorders, as well as in diseases in which macrophages are activated. The last decade has witnessed the appearance of a substantial number of studies attempting to unravel its cellular functions, which have yet not been fully defined. A great deal of progress has been made in the study of the physiological roles of ChT. This review is looks at the key areas of investigations addressed to further illuminate whether ChT activation might have different functional meanings in various diseases. Received 7 June 2006; received after revision 24 July 2006; accepted 21 September 2006     

Antigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity

It is now well demonstrated that the repertoire of T cells includes not only cells that recognize specific MHC-presented peptide antigens, but also cells that recognize specific self and foreign lipid antigens. This T cell recognition of lipid antigens is mediated by a family of conserved MHC class I-like cell surface glycoproteins known as CD1 molecules. These are specialized antigen-presenting molecules that directly bind a wide variety of lipids and present them for T cell recognition at the surface of antigen-presenting cells. Distinct populations of T cells exist that recognize CD1-presented lipids of microbial, environmental or self origin, and these T cells participate in immune responses associated with infectious, neoplastic, autoimmune and allergic diseases. Here we review the current knowledge of the biology of the CD1 system, including the structure, biosynthesis and trafficking of CD1 molecules, the structures of defined lipid antigens and the types of functional responses mediated by T cells specific for CD1-presented lipids.     

基于免疫技术的计算机防病毒入侵系统的设计与实现

提出了一种基于免疫技术的计算机防病毒入侵系统方案．该系统与传统的杀毒软件相比，最大的不同在于将杀毒软件的被动防御变为免疫系统的主动防御，使病毒与木马无法入侵操作系统，从而保障系统的安全工作．     

Protecting Terminals by Security Domain Mechanism Based on Trusted Computing

0 IntroductionEventhoughsignificant achievement has been madeinre-search of characteristic and abnormal actions of comput-er virus and attack, the investigation of defending the un-known computer virus and attackis progressing much slower .Under the conditions that attackers are much clever , newcomputer virus is presented continuously,the difference be-tween computer virus and normal programis less and lessclear ,detecting computer virus and attack will be more andmore difficult .Andto be the…