一种测定CO2驱最小混相压力的实验新方法

 为了缩短最小混相压力的测试时间,根据界面张力消失原理,提出了一种可以快速确定最小混相压力的实验新方法。该方法主要是利用可旋转的活塞式高压配样器,通过测定原油和CO₂混合过程中的压力变化来确定最小混相压力。利用该方法对华庆长6储层的原油与CO₂的最小混相压力进行测试,并与细管法测试结果进行对比,结果表明,测试结果与细管法的测试结果较接近,且该方法具有操作简单、实验过程耗时较短的特点。     

水驱后油藏氮气驱开发效果分析

辽河油田杜家台油层为低渗透储层,非均质性严重,开发时间长,含水率高,注水困难,为了改善杜家台油层开发效果,拟进行氮气驱开发。首先通过对杜家台油层原油进行了相态模拟研究,计算出了杜家台油层氮气驱最小混相压力(MMP),确定了杜家台油层氮气驱为非混相驱替。通过杜家台油层典型井组氮气驱开发的方案设计与指标预测,确定了氮气驱气水交替注入开发效果最佳;并优化出气水比、气水交替周期、注气速度、转注时机等参数。所提出的方案能明显改善该油藏开发效果,为杜家台油层及类似水驱油藏的开发调整提供依据。     

MMP3基因启动子rs102715950(5A/6A)单核苷酸多态性与河南人群食管鳞癌易感性的关系

为研究MMP3基因5'端转录调控区rs102715950(5A/6A)单核苷酸多态性与河南人群食管癌易感性的关系,通过蛋白酶K法提取基因组DNA,Nested PCR扩增目的基因片段,用Tth111I进行酶切,PAGE电泳检测酶切结果,对河南散发、正常、高发区3种人群进行了MMP3基因SNP rs102715950(5A/6A)基因分型,用SPSS软件作了Logistic回归统计分析.结果表明:在MMP3基因rs102715950(5A/6A)单核苷酸多态性上,河南食管癌散发人群、河南正常人群、湖北的河南移民人群3类人群相互之间并无显著性差异(p>0.01),说明MMP3基因rs102715950(5A/6A)单核苷酸多态性与河南人群的食管鳞癌易感性无显著相关性.     

Serum amyloid A: An acute-phase protein involved in tumour pathogenesis

The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by inflammation- associated cytokines and a high concentration of circulating SAA may represent an ideal marker for acute and chronic inflammatory diseases. However, SAA is also synthesized in extrahepatic tissues, e.g. human carcinoma metastases and cancer cell lines. An increasing body of in vitro data supports the concept of involvement of SAA in carcinogenesis and neoplastic diseases. Accumulating evidence suggests that SAA might be included in a group of biomarkers to detect a pattern of physiological events that reflect the growth of malignancy and host response. This review is meant to provide a broad overview of the many ways that SAA could contribute to tumour development, and accelerate tumour progression and metastasis, and to gain a better understanding of this acute-phase reactant as a possible link between chronic inflammation and neoplasia. Received 11 June 2008; received after revision 10 July 2008; accepted 28 July 2008