无锡DY电器公司库存管理优化方法研究

以无锡DY电器公司为研究对象,分析了该公司原有库存管理存在的问题及其原因,并从公司组织结构的设置、需求预测的建立、采购计划的完善、ABC法对物资的分类和管理、安全库存的合理设置、经济批量订货法的采用、供应商的评估和管理等方面提出了改善DY公司库存管理的具体优化方法.     

关于改进存货周转指标的探讨

存货周转率是分析企业的存货管理能力的重要指标。然而,传统的存货周转率计算公式存在着一定的问题,不能合理地反映存货的流转状况,从而无法对企业的营运状况作出正确的判断。本文从改进计算期平均存货余额的计算方法、结合ABC分类法以及结合资金流等方面提出相应的改进建议。     

基于改进搜索策略的混合蜂群算法

针对人工蜂群算法搜索效率低、易陷入局部最优和精度低等缺点,提出混合蜂群（hybrid bee colony, HBC)算法。将人工蜂群（artificial bee colony, ABC）算法局部收敛性与模拟退火（simulated annealing, SA）算法全局收敛性结合,为ABC算法提供了一种新机制。根据SA算法中Metropolis接受准则, 通过调整温度依概率确定全局最优解的替代值,并利用全局最优解的替代值和个体极值来改进ABC算法的引领蜂搜索模式。其次,改进侦察蜂搜索方式,根据迭代次数非线性减小侦察蜂搜索范围和以一定概率反向搜索更新方式,能够有效地提高算法的全局搜索能力,并加快算法的后期收敛速度。通过对8个复杂函数仿真测试,结果表明,HBC算法在搜索性能和精度方面均有明显提高。     

基于CDbw和人工蜂群优化的密度峰值聚类算法

针对密度峰值聚类(DPC)算法存在的d_c值难选择及近邻原则聚合操作在低密度区效果不佳的问题, 提出一种基于人工蜂群与CDbw聚类指标优化的密度峰值聚类（BeeDPC）算法, 以实现类簇间数据点的自动识别和合理聚类, 并解决DPC对类簇间数据点类别识别上存在的缺陷. 实验结果表明, BeeDPC算法具有自动识别并合理聚类类簇间数据点、 自动识别类簇中心点和类簇数量及自动处理任意分布数据集的优势.     

ABCA2: a candidate regulator of neural transmembrane lipid transport

Studies in the past years have implicated multispan transmembrane transport molecules of the ATP binding cassette (ABC) transporter family in cellular lipid export processes. The prototypic ABC transporter ABCA1 has recently been demonstrated to act as a major facilitator of cellular cholesterol and phospholipid export. Moreover, the transporter ABCA4 (ABCR) plays a pivotal role in retinaldehyde processing, and ABCA3 has recently implicated in lung surfactant processing. These pioneering observations have directed considerable attention to the A subfamily of ABC proteins. ABCA2 is the codefining member of the ABC A-transporter subclass. Although known for some time, it was not until recently that its complete molecular structure was established. Unlike other ABC A-subfamily members, ABCA2 is predominantly expressed in the brain and neural tissues. The unique expression profile together with available structural data suggest roles for this largest known ABC protein in neural transmembrane lipid export. Received 31 January 2002; received after revision 11 March 2002; accepted 11 March 2002     

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts numerous proteins involved in the trafficking of biological molecules across cell membranes. The first known human ABC transporter was P-glycoprotein (P-gp), which confers multidrug resistance (MDR) to anticancer drugs. In recent years, we have obtained an increased understanding of the mechanism of action of P-gp as its ATPase activity, substrate specificity and pharmacokinetic interactions have been investigated. This review focuses on the functional characterization of P-gp, as well as other ABC transporters involved in MDR: the family of multidrug-resistance-associated proteins (MRP1-7), and the recently discovered ABC half-transporter MXR (also known as BCRP, ABCP and ABCG2). We describe recent progress in the analysis of protein structure-function relationships, and consider the conceptual problem of defining and identifying substrates and inhibitors of MDR. An in-depth discussion follows of how coupling of nucleotide hydrolysis to substrate transport takes place, and we propose a scheme for the mechanism of P-gp function. Finally, the clinical correlations, both for reversal of MDR in cancer and for drug delivery, are discussed.     

业务流程再造中流程成本分析模型研究

根据作业成本法提出了更为实用的流程成本分析方法和模型，运用该模型可以指导企业进行流程成本分析，为企业再造提供更加详细、精确和动态的流程成本信息．研究结果表明，进行充分的业务流程成本分析，可以减少再造的盲目性，降低实施BPR项目的风险．     

作业成本的投入产出分析

作业成本是管理会计学中的概念,投入产出分析是统计学中的概念。产品在生产过程中不仅直接消耗作业,而且还通过消耗别的产品间接消耗作业从而消耗成本,本文旨在探索如何把作业成本合理客观地分配到产品的投入产出中。     

The ABC transporter structure and mechanism: perspectives on recent research

ATP-binding cassette (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic microbes to drugs. Elucidation of the structure and mechanism of ABC transporters is essential to the rational design of agents to control their function. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the proteins mechanism remain unanswered. In this review, we examine the recent structural data concerning ABC transporters and related proteins in the light of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters molecular mechanism.Received 29 August 2003; received after revision 19 November 2003; accepted 28 November 2003     

New paradigms of CFTR chloride channel regulation

The Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel controls salt and water transport across epithelial tissues. Alterations in the activity of this ion channel lead to two major human diseases: cystic fibrosis (low CFTR activity) and secretory diarrhea (excessive CFTR activity). The goal of this article is to review recent developments in our understanding of two aspects of CFTR biology: (i) interactions between CFTR domains (intramolecular interactions) that control the gating of this epithelial chloride channel and (ii) interactions between CFTR and other proteins (intermolecular interactions) that couple the activity of this ion channel to additional cellular processes in epithelial cells (e.g. membrane traffic). Clarifying the nature of these interactions may lead to the development of novel strategies for treating diseases that involve the CFTR chloride channel. Received 12 October 1999; accepted 31 December 1999