基于人工蜂群算法的改进研究与实现

参数的选择直接影响着最小二乘支持向量机(LSSVM)的泛化性能和回归效验,是确保LSSVM优秀性能的关键.为了解决以上问题,对人工蜂群算法(ABC)进行了改进,引入新解越界处理方法,研究了一种基于双种群策略的蜂群算法,同时提出提出一种运行时参数调整方法,然后验证优化后的算法IIABC的准确性与健壮性.燃气回归分析采用平均绝对百分比误差(MAPE)作为IIABC算法基准方法,实验结果表明基于IIABC-LSSVM预测结果比IABC-LSSVM有着更高的准确性.     

Cloning and functional analysis of the sequences flanking mini-Tn5 in the magnetosome-deleted mutant NM21 of Magnetospirillum gryphiswaldense MSR-1

A magnetosome-deleted mutant NM21 of Magnetospirillum gryphiswaldense MSR-1 was generated by mini-Tn5 lacZ2 transposon mutagenesis, and a 3073-bp fragment flanking mini-Tn5 lacZ2 in NM21 was cloned by Anchored PCR. Sequencing analysis showed that this fragment involved three putative ORFs; the mini-Tn5 lacZ2 was inserted into ORF1. Functional complementary test indicated that the 3073-bp fragment was required for biosynthesis of magnetosomes in M. gryphiswaldense MSR-1. The majority of proteins, which had h...     

The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation

A challenging task for the adaptive immune system of vertebrates is to identify and eliminate intracellular antigens. Therefore a highly specialized antigen presentation machinery has evolved to display fragments of newly synthesized proteins to effector cells of the immune system at the cell surface. After proteasomal degradation of unwanted proteins or defective ribosome products, resulting peptides are translocated into the endoplasmic reticulum by the transporter associated with antigen processing and loaded onto major histocompatibility complex (MHC) class I molecules. Peptide-MHC I complexes are transported via the secretory pathway to the cell surface where they are then inspected by cytotoxic T lymphocytes, which can trigger an immune response. This review summarizes the current view of the intracellular machinery of antigen processing and of viral immune escape mechanisms to circumvent destruction by the host. Received 4 October 2005; received after revision 19 November 2005; accepted 24 November 2005     

一种多粒子群切换决策机制

提出了一种切换决策机制,支持总最佳连接ABC(always best connected).该机制综合考虑接入网络状况、应用需求、用户对接入网络编码制式偏好、用户对接入网络供应商偏好、终端当前运动速率和终端当前剩余电量等因素,通过博弈分析,基于含最优变异的多粒子群优化算法,寻找把N个终端分配到M个接入网络的最佳切换决策方案,使用户和网络提供方效用达到或接近Nash均衡下的Pareto最优.仿真结果表明,该机制是可行和有效的.     

浅议技校电工基础课教学中的提问

在电工基础课的教学中，教师可用提问的方式吸引学生的注意力，同时鼓励学生大胆提问，这有助于培养学生对该课程的学习兴趣。     

应用ABS算法求解一类不定线性方程组

运用ＡＢＳ算法讨论了等式约束优化问题中的拉格朗日乘子法所形成的线性方程 组的求解问题；利用 ＡＢＳ算法的隐式 ＬＱ分解，通过有限步迭代求出原问题变量 的解，同时形成求解乘子的上三角系数阵的方程；给出了算法的具体过程，分析其数 值稳定性和计算量；作为特例，将最小二乘问题的法方程化为文中方程形式，并给出 了一种计算方法。     

Alzheimer's disease: fundamental and therapeutic aspects

Alzheimer's disease is the most common type of progressive and debilitating dementia affecting aged people. In some early — as well as late-onset familial cases, a genetic linkage with chromosomes 14, 21 (early-onset) or 19 (late-onset) has been indicated. Furthermore, a direct or indirect role has been attributed to normal or structurally altered amyloid -protein (concentrated in senile plaques) and/or excessively phosphorylated tau protein (located in neurofibrillary tangles). Degeneration of cholinergic neurons and concomitant impairment of cortical and hippocampal neurotransmission lead to cognitive and memory deficits. Several compounds are being tested in attempts to prevent and/or cure Alzheimer's disease, including tacrine, which has very modest efficacy in a sub-group of patients, and new acetylcholinesterase inhibitors. Pilot experiments have also been launched using nerve growth factor (NGF) to prevent or stabilize the processes of cholinergic pathway degeneration. Alternatively, antioxidants, free radical scavengers and/or non steroidal anti-inflammatory agents may be screened as potential therapies for neurodegenerative diseases induced by multiple endogenous and/or exogenous factors. The recent use of transgenic mice, in parallel with other genetic, biochemical and neurobiological systems, in vivo and/or in vitro (cell cultures), should accelerate the discovery and development of specific drugs for the treatment of Alzheimer's disease.     

benztropine类多巴胺转运蛋白配体的QSAR研究

利用Hansch方法，研究了37种benztropine类化合物diphenylmethoxy部位苯环取代基结构与其活性的定量关系，结果表明：苯环取代基的电性和体积等均是影响该类化合物与多巴胺转运蛋白亲和力的重要因素，所得到的benztropine类化合物diphenylmethoxy部位取代基的综合结构效应，对进一步研究该部位与多巴胺转运蛋白相互作用的电性和立体性质及设计新的多巴胺转运蛋白配体具有指导意义。     

双圈图的原子键连通性指数

1998年,Estrada等人在Randi’c指数的基础上进一步提出了原子键连通性指数,简称ABC指数.该指数已被用来研究烷烃的稳定性以及环烷烃的应变能等.该文给出了双圈图ABC指数的上界并确定了具有最大ABC指数的双圈图.     

多巴胺系统在甲基苯丙胺成瘾中的作用

目的:研究多巴胺系统在甲基苯丙胺成瘾中的作用。方法:通过查阅近年来国内外专家对甲基苯丙胺对多巴胺、多巴胺受体、多巴胺转运体的作用,总结多巴胺系统在甲基苯丙胺成瘾中的作用。结果:多巴胺系统在甲基苯丙胺成瘾过程中起重要作用。结论:研究清楚多巴胺系统在甲基苯丙胺成瘾中的作用,为甲基苯丙胺成瘾治疗寻找有效靶点。