用可编程控制器实现的重型平台运输车转向控制系统

根据 1 30t升降平台运输车对转向系统的特殊要求 ,通过分析转向驱动机构的传动特性 ,采用C2 0 0HG可编程控制器为核心设计了该车的转向控制系统 ,编制了控制软件 在以PID为基础的控制算法中结合车轮的不同位置和偏转方向进行计算修正 ,达到了车轮在所处的任意位置向左或向右偏转时 ,转向系统的工作速度特性都基本保持一致 从而使转向过程中各车轮组之间的偏转关系始终满足车辆转向特性要求 ,实现转向控制系统的准确、稳定和快速灵敏     

浅谈产品成本ABC制度

财务管理是企业管理的一个中心环节，成本管理又是财务管理的一个重要环节。随着我国市场经济的不断完善，企业间产品的市场竞争日趋激烈，产品成本的高低已成为竞争的一个焦点。所以加强成本管理、合理计算产品成本，就可为产品市场竞争创造出良好的空间环境。ＡＢＣ成本管理制度是管理和计算产品成本的一种合理有效方法，它将成本中的间接费用按成本动因分别进行分配，使产品成本的构成更趋合理，这就是它的新颖所在。文章对ＡＢＣ成本管理制度的基本作用、工作原理、成本动因概念、制度设计程序及对现代企业管理的贡献作了阐述。     

Effect on membrane transport in the erythrocytes by band 3 cross-linking

Band 3 and glucose transport protein (GluT1) are two kinds of important proteins in the human erythrocyte membranes. Bis(sulfosuccinimidyl)suberate (BS³), an impermeable cross-linker of band 3, inhibited NO₂ ⁻ transport, showing that anion exchange is affected by the association state of band 3 in the intact erythrocyte membranes. At the same time, the rates of glucose transport of both exit and entry declined. The amount of monomers of band 3 was decreased after treatment of the erythrocytes with BS³, but there was no change in GluT1 according to the SDS-PAGE patterns. This demonstrates that band 3 and GluT1 would be linkaged together in the erythrocyte membranes for the requirement of rapid and cooperative performance of physiological functions of the membrane proteins.     

ABC管理法在银行贷款管理中的应用

从我国银行贷款管理特点出发，针对贷款风险问题，探讨了ＡＢＣ管理法在贷款管理中的应用，为银行贷款管理提供一种有效的技术方法．     

Iron metabolism in the mononuclear phagocyte system

The maintenance of body iron homeostasis requires the coordination of multiple regulatory mechanisms of iron metabolism. The mononuclear phagocyte system （MPS, composed of monocytes, macrophages, and their precursor cells） is crucial in the maintenance of iron homeostasis. Recycling of iron is carried out by specialized macrophages via engulfment of aged erythrocytes. The iron stores of macrophages depend on the levels of recovered and exported iron. However, the molecular mechanisms underlying iron homeostasis in macrophages are poorly understood. Recent studies characterizing the function and regulation of natural resistance-associated mac- rophage protein 1 （Nrampl）, divalent metal transporter 1 （DMT1）, HLA-linked hemechromatosis gene （HFE）, ferroportin 1 （FPN1）, and hepcidin are rapidly expanding our knowledge on the molecular level of MPS iron handling. These studies are deepening our under- standing about the molecular mechanism of iron homeostasis and iron-related diseases.     

An effective absorbing boundary algorithm for acoustical wave propagator

In this paper,Berenger's perfectly matched layer(PML)absorbing boundary condition for electromagnetic waves is introduced as the truncation area of the computational domain to absorb one-dimensional acoustic wave for the scheme of acoustical wave propagator(AWP).To guarantee the efficiency of the AWP algorithm,a regulated propagator matrix is derived in the PML medium.Numerical simulations of a Gaussian wave packet propagating in one-dimensional duct are carried out to illustrate the efficiency of the combination of PML and AWP.Compared with the traditional smoothing truncation windows technique of AWP,this scheme shows high computational accuracy in absorbing acoustic wave when the acoustical wave arrives at the computational edges.Optimal coefficients of the PML configurations are also discussed.     

基于功能区域方法的项目安全性分析

利用传统方法进行工业项目的安全性分析,安全效益和安全价值都只能部分地反映系统的安全状况,所得分析结果对改善方案安全效果的作用很有限且应用性不强.通过引入价值分析理论,建立安全效益-价值联立方程和优选判据,再结合最合适区域法,最终形成了功能区域分析方法和理论.将功能区域方法应用于实际工程项目中,根据项目技术数据得出最合适曲线和区域分析结果,极大地改善了项目的安全价值和成本.     

Nucleotide binding domains of human CFTR: a structural classification of critical residues and disease-causing mutations.

Defective function of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) causes CF, the most frequent lethal inherited disease among the Caucasian population. The structure of this chloride ion channel includes two nucleotide-binding domains (NBDs), whose ATPase activity controls channel gating. Recently, the experimental structures of mouse and human CFTR NBD1 and our model of the human CFTR NBD1/NBD2 heterodimer have provided new insights into specific structural features of the CFTR NBD dimer. In the present work, we provide a structural classification of CF-causing mutations which may complement the existing functional classification. Our analysis also identified amino acid residues which may play a critical role in interdomain interaction and are located at the NBD1-NBD2 interface or on the surface of the dimer. In particular, a cluster of aromatic amino acids, which includes F508 and straddles the two NBDs, might be directly involved in the interaction of the NBD1/NBD2 heterodimer with the channel-forming membrane-spanning domains.Received 24 May 2005; received after revision 13 June 2005; accepted 18 June 2005     

钠离子依赖的中性氨基酸转运蛋白SNAT2-HA融合蛋白的构建及鉴定

钠离子依赖的中性氨基酸转运蛋白SNAT2在哺乳动物组织中广泛表达,具有转运中性氨基酸的功能,在谷氨酸-谷氨酰胺循环、肝脏糖质新生等生物通路中发挥重要作用．为了方便测定SNAT2在细胞膜上的表达和定位,本研究采用PCR扩增和酶切连接将HA标签蛋白与SNAT2的C末端连接,构建了真核生物表达载体pBK-CMVA（1098—1300）-SNAT2-HA表达载体．用脂质体转染法将该表达载体瞬时转染到HEK293T细胞中,通过Westernblot法检测到SNAT2-HA融合蛋白在细胞膜上的正确表达和定位．pBK-CMV△（1098-1300）-SNAT2-HA表达载体的成功构建,为今后对SNAT2的结构和功能的研究提供了有效方法．     

煤矸石发电厂气力除灰控制系统分析研究

简要介绍了某煤矸石发电厂1号炉、2号炉气力正压密相气力输灰系统及其操作,论述了布袋除尘器飞灰输送逻辑描述、除灰步序,详细分析了DCS控制系统在电厂除灰控制系统中的应用特点。