中医药高校图书馆在老龄社会阅读服务中的作用研究

在全民阅读的热潮中,中医药高校图书馆应以自身的优势构建适合老龄社会阅读的服务模式。分析了中医药高校图书馆在推进老龄社会阅读服务中的优势,阐述了中医药高校图书馆在老龄社会的阅读服务现状,提出了中医药高校图书馆推进老龄社会阅读服务的策略。     

应用结构方程模型研究中药药性和药味间关系

应用结构方程模型研究了200味中药药性和药味间的相互关系.结果表明,五种药味间存在一定的相关性,其中关系最强位于甜味与酸味间,中药药性与五味也存在相关关系,分析表明甜味与酸味在较大程度上影响药性.     

应用高分子材料整治铁路桥梁支座病害

分析了铁路桥梁支座病害的成因,介绍了应用高分子材料整治桥梁支座病害的施工工艺和取得的效果.     

可吸入颗粒污染物在下呼吸道运动和沉积规律的数值模拟

为研究受慢性阻塞性肺病影响的呼吸道内气固流动特性,建立了基于Weibel模型的5～8级三维肺部模型.气相采用标准k-ε湍流模型,颗粒相采用离散颗粒模型.三级呼吸道内模拟的气固流动特性与实验结果进行了对比验证.在呼吸强度为30,60和90 L/min条件下,模拟了稳态、非稳态吸气时第7级内侧呼吸道受慢性阻塞性肺病影响收缩...     

“花柳病”概念探源补遗

当今我国学者普遍将花柳病等同于性病,认为花柳病是性病在旧社会的称谓或者是一种民间称法。本文通过对花柳病概念进行溯源,认为这种看法是缺乏历史依据的:花柳一词作为对妓女等的雅称始于唐代,但是作为一种疾病的名称则始于日本,自19世纪中后期被引入中国之后,它又经历了近代医学的洗礼和改造,成为了一个充满本土感的近代词汇。     

浅谈红层地区小型水库的常见地质病害

根据对自贡地区300余座小一型及小二型水库病害的分析、统计,列出红层地区小型水库的普遍性地质病害,为川南、川北以及川东地区的水库病害整治提供一点借鉴作用。     

三种方法测定碱性磷酸酶对肝疾病的诊断价值

目的研究血清碱性磷酸酶检测临床肝疾病时的方法学,提高临床诊断价值。方法收集临床不同肝疾病病人的血清,分别用3种方法测定其碱性磷酸酶的活性,并与健康对照组比较作诊断性能分析。结果各肝疾病组血清碱性磷酸酶的活性与对照组相比有极显著差异（P〈0．001）;3种方法分别测定各组之闻的血清碱性磷酸酶活性无显著性差异（P〉0．05）。2．乙基氨基乙醇、2-氨基-2-甲基-1-丙醇、二乙醇胺3种缓冲液测定试剂盒方法测定的灵敏度分别为55．20％、47．96％、51．13％,特异度分别为100％、100％、93．75％。结论血清碱性磷酸酶可以作为各类肝病的临床诊断指标;对肝疾病血清碱性磷酸酶测定用2,乙基氨基乙醇缓冲液的试剂方法测定效果较好。     

Functions and pathologies of BiP and its interaction partners

The endoplasmic reticulum (ER) is involved in a variety of essential and interconnected processes in human cells, including protein biogenesis, signal transduction, and calcium homeostasis. The central player in all these processes is the ER-lumenal polypeptide chain binding protein BiP that acts as a molecular chaperone. BiP belongs to the heat shock protein 70 (Hsp70) family and crucially depends on a number of interaction partners, including co-chaperones, nucleotide exchange factors, and signaling molecules. In the course of the last five years, several diseases have been linked to BiP and its interaction partners, such as a group of infectious diseases that are caused by Shigella toxin producing E. coli. Furthermore, the inherited diseases Marinesco-Sj?gren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological characteristics of BiP and its interaction partners. Received 20 November 2008; received after revision 09 December 2008; accepted 12 December 2008     

Transient and constitutive repression of cytoplasmic translation signaling in cells with mtDNA mutation

Cytoplasmic translation is under sophisticated control but how cells adapt its rate to constitutive loss of mitochondrial oxidative phosphorylation is unknown. Here we show that translation is repressed in cells with the pathogenic A3243G mtDNA mutation or in mtDNA-less ρ⁰ cells by at least two distinct pathways, one transiently targeting elongation factor eEF-2 and the other initiation factor eIF-2α constitutively. Under conditions of exponential cell growth and mammalian target of rapamycin (mTOR) activation, eEF-2 becomes transiently phosphorylated by an AMP-activated protein kinase (AMPK)-dependent pathway, especially high in mutant cells. Independent of AMPK and mTOR, eIF-2α is constitutively phosphorylated in mutant cells, likely a signature of endoplasmic reticulum (ER)-stress response induced by the loss of oxidative phosphorylation. While the AMPK/eEF-2K/eEF-2 pathway appears to function in adaptation to physiological fluctuations in ATP levels in the mutant cells, the ER stress signified by constitutive protein synthesis inhibition through eIF-2α-mediated repression of translation initiation may have pathobiochemical consequences. Received 29 October 2008; received after revision 11 December 2008; accepted 16 December 2008     

The trefoil factor family – small peptides with multiple functionalities

The trefoil factor family (TFF) comprises a group of small peptides which are highly expressed in tissues containing mucus-producing cells – especially in the mucosa lining the gastrointestinal tract. The peptides seem crucial for epithelial restitution and may work via other pathways than the conventional factors involved in restitution. In vitro studies have shown that the TFFs promote restitution using multiple mechanisms. The peptides also have other functionalities including interactions with the immune system. Moreover, therapeutic effects of the TFFs have been shown in several animal models of gastrointestinal damage. Still it is not clear which of their in vitro properties are involved in the in vivo mode of action. This review describes the TFF family with emphasis on their biological properties and involvement in mucosal protection and repair. Received 10 October 2008; received after revision 07 November 2008; accepted 10 November 2008