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A new entire biodegradable scaffold has been developed which does not require precelluiarization before transplantation. This new kind of vascular scaffold prototype made from porous poly- e-caprolactone (PCL) membrane to provide three-dimensional environment for cell growth, and embedded with weft-knitted polylactic acid (PLA) fabric to support mechanics. The aim of this paper is to study the variation tendency of mechanical properties with the fabric spacing changing. The basic geometrical parameters were measured to characterize properties of the samples. The tensile and compressive elastic recovery of the samples were tested by the universal mechanical tester and radial compression apparatus, respectively. Both tensile and compressive properties enhanced when reducing the fabric spacing of the composite vascular scaffold. 相似文献
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Wenting Zheng Di Guan Yuxin Teng Zhihong Wang Suai Zhang Lianyong Wang Deling Kong Jun Zhang 《科学通报(英文版)》2014,59(22):2776-2784
Poly(e-caprolactone)(PCL)is widely adopted as an ingredient for tissue engineering scaffolds.To improve its cell affinity,in this study,we developed a new method to introduce bioactive RGD peptides onto the surface of PCL via condensation reaction between 2-cyanobenzothiazole(CBT)and D-cysteine.The PCL fibrous membranes were prepared by electrospinning,and RGD functionalization was characterized by fluorescence microscopy,scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS)and water contact angle(WCA).As expected,our results demonstrated the successful RGD immobilization on the surface of PCL.RGD modification improved the hydrophilicity of PCL,changing their WCA from 112.20°to38.35°.Cell adhesion,spreading and proliferation of 3T3fibroblasts were also enhanced.We therefore believe that the methods reported in this study was facile and effective for functional modification of the hydrophobic PCL scaffolds.The moderate reaction conditions are also suitable for covalent immobilization of bioactive molecules onto PCL. 相似文献
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Disc-electrospinning using a disc as spinneret and a rotary drum as collector is a novel technology to prepare nanofiber which has been applied in tissue engineering scaffolds. In this study, nanofibrous mats with mlcro-patterned structure were fabricated via disc-electrospinning. Poly (ε-eaprolactone) (PCL) was dissolved in trifluoroethanol (TFE) at various concentrations ( 2 %-7 % ) (w/v) for electrospinning and the applied voltage ranged from 40 to 70 kV. Scanning electron microscopy (SEM) was employed to observe the morphology of the nanofibrous scaffolds. SEM images illustrated that the nanofibers with beads formed micro-patterned structure such as triangles and other polygons. The average diameter of nanofibers presented various size with the concentration increased from 2% to 7%. The beads on the nanofibers constructed the vertexes of the polygons, while nanofibers bridged between adjacent vertexes. The concentration of solution and applied voltage may be two dominant factors to influence the topological structure of the nanofibrons scaffolds. Cells cultured on the micro-patterned scaffold spread along the edges of the polygons. The scaffold with patterned structure may have a promising application in tissue engineering. 相似文献
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本文介绍了有限元中能量法,包括虚拟裂纹闭合法(VCCM)及等效区域J积分(EDI)计算线弹性断裂力学参数的思路;使用PCL语言在MSC.Patran中开发了能量法计算应力强度因子的模块,该模块可用于任意二维线弹性断裂力学参数的求解,最后通过算例验证了该模块的计算结果,并讨论了网格对计算精度的影响。 相似文献
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在得到飞机壁板结构的有限元分析结果之后,需要利用工程方法对此计算结果进行评估,最终得到壁板结构的强度评估结果。以有限元软件MSC.Patran为平台,利用其二次开发语言PCL(PATRAN Command Language),通过自动加载编译函数文件、用户自定义菜单和图形界面和读取结果等技术,开发了飞机壁板结构强度校核系统。使用此系统对某些典型的壁板结构案例进行了分析,结果表明该程序不仅能够满足较大范围内的各种飞机壁板结构的强度校核要求,而且还可以大大提高飞机设计者的工作效率。 相似文献
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The mechanical properties and water solubility of electrospinning SF films limit their use as biomaterials. In order to develop a tissue engineering biomaterial with both satisfying biological properties and sufficient biomechanical properties,blended films composed of silk fibroin( SF) and poly( ε-caprolactone)( PCL) were fabricated by electrospinning in this study. Scanning electron microscope( SEM), X-ray diffraction( XRD),thermal analysis,Fourier transform-infrared( FT-IR),Raman spectra,mechanical testing,and water solubility were used to characterize the morphological, structural and mechanical properties of the blended electrospinning films. Results showed that the diameter of the blended fiber was distributed between 600 and1000 nm,and the fiber diameter increased as the PCL content increased. There is no obvious phase separation due to the similarity and intermiscibility,as well as the interactions( mainly hydrogen bonds), between the two polymers. Meanwhile, the secondary structures of SF changed from random coils and Silk I to Silk II because of the interactions between SF and PCL. For this reason,the tensile strength and elongation at break of the electrospinning films improved significantly,and the water solubility decreased. In conclusion,the blended electrospinning films fabricated in this study showed satisfying mechanical properties and water insolubilities,and they may be promising biomaterials for applications in tissue engineering for blood vessels,nerve conduits,tendons,ligaments and other tissues. 相似文献
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基于产品生命周期的服装库存管理智能决策 总被引:1,自引:0,他引:1
从案例分析出发,深入分析服装产品生命周期的特点及其不同阶段对应的库存管理的特点;并基于此提出了服装库存管理的智能决策构架。 相似文献
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PATRAN环境下飞机红外辐射模型系统集成的实现 总被引:1,自引:0,他引:1
本文简要介绍了一个基于PATRAN的工程分析软件CFX5,分析了PCL(PA-TRANCommandLanguage)的集成定制特征及其类的功能与结构。论述了飞机红外辐射模型系统在PATRAN环境下的系统集成方法。 相似文献