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41.
WUKefu MAXiaotong 《科学通报(英文版)》2003,48(22):2519-2522
Proinflammation represents a pathophysiological state on the early stage of a number of diseases, especially the infectious and immunological ones. In recent years, proinflammation has attracted much attention, and the term 損roinflammation factors?appears frequently in the literature. While investigating leukemia and leukemic cells from the angle of 損roinflammation state? we got some intriguing findings, e.g. we detected the significantly elevated expression of proinflammation factor IL-18 in patients with acute myeloid leukemia (AML), which could up-regulate matrix metalloproteinases (MMP) and specific tissue inhibitors (TIMPs). The increased MMP may play a role in the aggressiveness of myeloid leukemic cells, and be associated with a poor prognosis. This phenomenon reflects an ignored aspect of leukemia. Investigations from the angle of 損roinflammation state?have broaden the fields of tumor and leukemia study. 相似文献
42.
用海萝多糖粗提物灌胃昆明种小鼠,观察海萝多糖粗提物对环磷酰胺(CP)诱发小鼠染色体突变和精子畸变的抑制作用和对荷S180肉瘤小鼠的抑瘤作用.实验结果显示:海萝多糖粗提物可使环磷酰胺诱发的小鼠骨髓嗜多染红细胞(PCE)微核率和精子畸形率明显降低,具有显著的抗突变作用,且呈现一定的剂量效应关系;海萝粗多糖对S180肉瘤也有明显的抑制作用,并有一定的剂量关系.结果表明,海萝多糖粗提物有明显的抗突变、抗肿瘤作用. 相似文献
43.
目的:研究姜黄素对人低分化鼻咽癌细胞系亚克隆株CNE-2Z—HS裸鼠移植瘤生长和增殖的影响。方法:复制人低分化鼻咽癌细胞系亚克隆株CNE-2Z-H5裸鼠移植瘤模型,观察姜黄素对移植瘤生长的影响。结果裸鼠体内实验显示姜黄素可以抑制移植瘤的生长。不同浓度姜黄素组移植瘤瘤重与溶剂对照组比较有降低趋势,高剂量组降低更明显,差异有极显著性(P〈O.001),抑瘤率达59.75%。结论姜黄素可以抑制CNE-2Z—H5细胞裸鼠移植瘤的生长,其可能在鼻咽癌的治疗中具有一定的价值,值得进一步深入研究。 相似文献
44.
目的探讨手术切除治疗甲状腺肿瘤的疗效。方法回顾分析我院2005至2007年收治的62例甲状腺肿瘤的患者资料,根据病情分别采用单侧甲状腺叶切除或者腺瘤单切加腺叶部分切除法,对其治疗效果、风险及并发症进行分析。结果62例患者术后除1例皮下出血,1例复发外,无喉返神经、喉上神经损伤,无永久性甲状旁腺甲状腺功能低下。结论单侧甲状腺叶切除或者腺瘤单切加腺叶部分切除法治疗甲状腺肿瘤并发症少,临床效果满意。 相似文献
45.
46.
Metabonomic analysis of hepatitis B virus-induced liver failure: identification of potential diagnostic biomarkers by fuzzy support vector machine
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Yong MAO ;Xin HUANG ;Ke YU ;Hai-bin QU ;Chang-xiao LIU ;Yi-yu CHENG 《浙江大学学报(自然科学英文版)》2008,(6):474-481
Hepatitis B virus (HBV)-induced liver failure is an emergent liver disease leading to high mortality. The severity of liver failure may be reflected by the profile of some metabolites. This study assessed the potential of using metabolites as biomarkers for liver failure by identifying metabolites with good discriminative performance for its phenotype. The serum samples from 24 HBV-indueed liver failure patients and 23 healthy volunteers were collected and analyzed by gas chromatography-mass spectrometry (GC-MS) to generate metabolite profiles. The 24 patients were further grouped into two classes according to the severity of liver failure. Twenty-five eommensal peaks in all metabolite profiles were extracted, and the relative area values of these peaks were used as features for each sample. Three algorithms, F-test, k-nearest neighbor (KNN) and fuzzy support vector machine (FSVM) combined with exhaustive search (ES), were employed to identify a subset of metabolites (biomarkers) that best predict liver failure. Based on the achieved experimental dataset, 93.62% predictive accuracy by 6 features was selected with FSVM-ES and three key metabolites, glyeerie acid, cis-aeonitie acid and citric acid, are identified as potential diagnostic biomarkers. 相似文献
47.
总结了广西三盆地3种第三系褐煤的多环芳烃特征,主要包括芳香倍半萜,二倍半萜和三萜类。其中以陆源奥利烷,乌散烷和羽扇烷前生物衍生而来的单芳于四芳三萜烃类为主,芳香二倍半萜,倍半萜次之 。 相似文献
48.
W. Roszkowski J. Beuth H. L. Ko G. Uhlenbruck G. Pulverer 《Cellular and molecular life sciences : CMLS》1989,45(6):584-588
Summary Adhesion and inhibition experiments with pulmonary cells of BALB/c-mouse origin and syngeneic sarcoma L-1 cells indicated that L-fucose specific lectin-like adhesion molecules, presumably situated on pulmonary cell surfaces are (at least partly) responsible for the specificity of this cell-cell interaction. Addition of specific sugars and glycoconjugates (L-fucose and fucoidan, respectively) to the incubation medium evidently inhibited the adhesion process as quantified using radiolabelled tumor cells. Unspecific carbohydrates (e.g. D-galactose) did not affect the cellular interaction. In vivo, repeated administration of fucoidan (but not of unspecific glycoconjugates) significantly inhibited the settling of metastatic sarcoma L-1 cells in the lungs of BALB/c-mice. Therefore, when lectin-like adhesion molecules on pulmonary cells were blocked with competitive glycoconjugates, tumor cell colonization of the lung could be significantly inhibited. 相似文献
49.
M. Gumińska M. B. Stachurska B. Christensen V. Tromholt J. Kieler Cz. Radzikowski D. Duś 《Cellular and molecular life sciences : CMLS》1989,45(6):571-574
Summary It was found that a decrease in electrophoretic mobility of pyruvate kinase (PK) isoenzyme, and an increase of the sensitivity of this enzyme to L-cysteine, were markers of immortalization and tumorigenic properties, respectively, in human urothelial cell lines characterized by different grades of transformation (TGr) in vitro. 相似文献
50.