慢性充血性心力衰竭过程中的肿瘤坏死因子及其受体

慢性充血性心力衰竭病人血清中TNFα水平升高，当其≥10^-8mol/L时，可能作为内分泌激素，通过与其受体(膜结合型及可溶型)结合，直接损伤心肌纤维，影响心肌细胞凋亡过程，引起或促进心功能不全的发生。TNF途径成为充血心衰发病机制中的新内容。可考虑应用TNFr拮杭剂治疗心衰。     

活菌作为抗肿瘤制剂和肿瘤基因治疗载体的研究

随着细菌生物学和分子生物学的发展，细菌抗癌治疗的应用更为广泛，其可增加化疗药物的敏感性，增强抗癌药物作用，并作为基因治疗的载体，细菌毒素本身就可以用来攻克肿瘤，而最有应用前景的是，经遗传修饰的细菌作为自杀基因载体选择性地破坏肿瘤细胞，保护正常组织不受损坏。文章就活菌作为抗肿瘤制剂和肿瘤基因治疗栽体的研究进展进行综述。     

透明质酸在肿瘤新血管生成中的作用

阐述了透明质酸寡聚糖对上皮细胞作用的过程，即从与细胞表面受体结合到激活信号传导途径，以及表达成蛋白质进行细胞增生和转移。     

循证医学对肿瘤临床实践的指导意义

介绍循证医学产生的背景及其对肿瘤临床的实践意义，肿瘤学循证医学文献检索的几种主要的数据库。     

气泡塔熔融结晶器中传递与晶层生长

分析了气泡塔结晶器熔融结晶过程中自熔体向晶层界面的热、质传递特征，建立了描述该过程晶层生长的稳态模型。在自熔体向晶层界面对流传热膜系数的计算中，将弹单元分为弹状气泡周围液膜区、尾迹区及液塞段3段，各段的平均对流传热膜系数不同。分别在表观气速0.04和0．08m/s下，用模型对己内酰胺晶层生长进行了计算，计算结果与实验结果基本吻合。     

Advances in identification and application of tumor antigen inducing anti-cancer responses

Tumor antigen is one of the important bases of tumor immunotherapy . With the discovery of novel tumor antigens, interest in specific immunotherapy for treatment of malignancies has increased substantially. Nowadays more and more scientists paid close attention to various tumor antigens with their roles or/and applications in anti-cancer immune responses, immune tolerance, tumor markers,     

Classification of Medical Brain Images

Since brain tumors endanger people‘s living quality and even their lives, the accuracy of classification becomes more important. Conventional classifying techniques are used to deal with thosedatasets with characters and numbers. It is difficult, however, to apply them to datasets that include brain images and medical history (alphanumeric data), especially to guarantee the accuracy.For these datasets, this paper combines the knowledge of medical field and improves the traditional decision tree. The new classification algorithm with the direction of the medical knowledge not only adds the interaction with the doctors, but also enhances the quality of classification. The algorithm has been used on real brain CT images and a precious rule has been gained from the experiments. This oaoer shows that the ahzorithm works well for real CT data.     

猪苓母种培养基筛选研究

对猪苓[Grifola umbellata(Pets．ex Fr．)Pilat]进行了母种培养基筛选试验，结果表明，猪苓母种生长的最适培养基为：马铃薯100g，蔗糖10g，磷酸二氢钾1g，硫酸镁0．25g，维生素B15mg，琼脂9g．     

盐碱土壤修复材料对作物生长影响研究

本实验是利用以牡蛎壳为主要材料的3种不同用量的盐碱土壤修复材料，处理含盐量为2的低度盐碱土壤，对作物油菜的形态及其生理生化指标进行对比测量，用以观察此修复材料对盐碱土壤的修复作用。实验表明，此修复材料对种植40d后的油菜的出苗率无显著影响，而对叶长、叶宽等形态有明显影响。改良后的盐碱土上生长的油菜的叶绿素含量及叶绿素a与叶绿素b的比值均上升；叶片类囊体膜H —ATPase活性上升，证明此盐碱土壤修复材料对盐碱土壤具一定的修复作用，且其修复作用与修复材料的添加用量有关。     

Inhibitory effect of the adenovirus type 5 E1A protein expressed in the yeast system of the human tumor cell growth

Adenovirus 5 type E1A as a tumor suppressor gene can inhibit tumor growth and enhance the censitivity of chemotherapy and radiotherapy.E1A have the ability to integrate into the host genome,resulting in long-time expres-sion that induces Rb gene inactivation and animal cells im-mortalization.This prompted us to select the E1A protein for treatment of cancer in order to overcome the limitations of E1A gene therapy.Thus,we firstly comstructed E1A eu-caryotic expression vector (pPIC9/E1A),transformated the pichia pastoris yeast cells(GS115) and screened the high-expressing recombinant strains.The positive yeast strains were cultured in the shake flask,and induced for 3d.The crude E1A protein was purified using two steps of col-umu chromatography on HiTrap Q and HiTrap SP.The pu-rified E1A protein was identified by SDS-PAGE and Western blot.E1A protein was mostly located at cellular unclear when Cheriot delivered E1A protein into cells.The analysis in vitro indicated that the E1A protein arrested LN686 cell cycle at G2/M phase,and significantly inhibited the growth of LN686 tumor cells.The current studies firstly provided an experimental basis to further develop E1A protein for tumor treatment.