Reconstruction of linkage maps in the distorted segregation populations of backcross, doubled haploid and recombinant inbred lines

Non-Mendelian segregation of markers, known as distorted segregation, is a common biological phenomenon. Although segregation distortion affects the estimation of map distances and the results of quantitative trait loci (QTL) mapping, the effects of distorted markers are often ignored in the construction of linkage maps and in QTL mapping. Recently, we have developed a multipoint method via a Hidden Markov chain method to reconstruct linkage maps in an F2 population that corrects for bias of map distances between distorted markers. In this article, the method is extended to cover backcross, doubled haploid and recombinant inbred line (RIL) populations. The results from simulated experiments show that: (1) the degree that two linked segregation distortion loci (SDL) affect the estimation of map distances increases as SDL heritability and interval length between adjacent markers increase, whereas sample size has little effect on the bias; (2) two linked SDL result in the underesti- mation of linkage distances for most cases, overestimation for an additive model with opposite additive effects, and unbiased estimation for an epistatic model with negative additive-by-additive effects; (3) the proposed method can obtain the unbiased estimation of linkage distance. This new method was applied to a rice RIL population with severely distorted segregation to reconstruct the linkage maps, and a bootstrap method was used to obtain 95% confidence intervals of map distances. The results from real data analysis further demonstrate the utility of our method, which provides a foundation for the inheritance analysis of quantitative and viability traits.     

遗传学教学的改革与实践

遗传学是农科院校的一门核心基础课，也是生物科学的重要基础学科，近年来遗传学及其相关学科的研究进展很快，为使遗传学课程教学适库这一形势，获得良好的教学效果，就必须加强遗传学课程的改革，加强实践环节。文章从遗樗学教学大纲修订、多媒体辅助对教学改革及自主性实验教学改革等方面对我们在遗传学教学改革的一些做法和成效进行了介绍和分析，以期进一步促进我们遗传学教学水平的提高。     

近亲姻缘的利与弊

自古以来，人们就认识到人类自身及各种动物的个体之间存在着血亲关系，但受限于当时的遗传学知识，人们并不能很好地界定这种关系，通常的说法都是针对人类自身的描述。譬如，我国古代即有“九族五服”、“三亲六戚”之说，用于界定亲缘关系的远近。随着现代遗传学的发展，人们知道了这些血缘上的近亲其实源自个体之间遗传基因的相似程度，亲属关系越近则遗传基因越相似。就人类而言，     

人类基因组研究和伦理学

首先在引言中简单介绍人类基因组研究及其重要意义。然后探讨人类基因组研究计划中的概念、理论预设、目的和价值以及伦理问题。最后对人类基因治疗的政策问题进行了分析。     

精神分裂症的遗传损伤基础

人类中约有1％的人群经受着精神分裂症的折磨，虽然精神分裂症是家族性的，但是其遗传方式就像这一疾病本身那样复杂。早前曾有研究宣布鉴定了一个精神分裂症基因，但是该结果却存在解释困难和重现性差的问题。最近发表的两篇论文阐明了为什么精神分裂症基因这么难以捉摸，更重要的是，还阐明了这一疾病的遗传学基础。     

《遗传学》精品课程简介

遗传学是大理学院生物科学、生物技术和园艺学专业的重要专业基础课。经过多年的建设，遗传学教研室已建成了一支教学经验丰富，教学质量高，科研能力、合作精神和团队意识较强的师资队伍。主讲教师队伍中有教授3人，高级实验师2人，讲师1人，其中博士1人，硕士2人。教师中有多人次被评为学校优秀教师和教学效果优秀教师，1人被评为云南省中青年学术带头人后备人才。2006年遗传学被评为校级精品课程。