提高高频晶闸管di/dt耐量的研究

为提高高频晶闸管的动态指标和高频性能，通过实验分析和理论推导，研究了工艺参数和设计参数对高频晶闸管ｄｉ／ｄｔ耐量的影响。实验结果表明：较低的一扩浓度，较薄的基区宽度以及用高能电子辐照控制少子寿命，有利于提高ｄｉ／ｄｔ耐量。通过对相同工艺三种不同阴极图形的８００Ａ、１０ｋＨｚ高频晶闸管ｄｉ／ｄｔ的研究，论证了合理确定辅助晶闸管面积对提高ｄｉ／ｄｔ的重要性，并指出，在大面积高频晶闸管中设计二级放大门极，有利于提高ｄｉ／ｄｔ耐量。     

Alzheimer's disease: fundamental and therapeutic aspects

Alzheimer's disease is the most common type of progressive and debilitating dementia affecting aged people. In some early — as well as late-onset familial cases, a genetic linkage with chromosomes 14, 21 (early-onset) or 19 (late-onset) has been indicated. Furthermore, a direct or indirect role has been attributed to normal or structurally altered amyloid -protein (concentrated in senile plaques) and/or excessively phosphorylated tau protein (located in neurofibrillary tangles). Degeneration of cholinergic neurons and concomitant impairment of cortical and hippocampal neurotransmission lead to cognitive and memory deficits. Several compounds are being tested in attempts to prevent and/or cure Alzheimer's disease, including tacrine, which has very modest efficacy in a sub-group of patients, and new acetylcholinesterase inhibitors. Pilot experiments have also been launched using nerve growth factor (NGF) to prevent or stabilize the processes of cholinergic pathway degeneration. Alternatively, antioxidants, free radical scavengers and/or non steroidal anti-inflammatory agents may be screened as potential therapies for neurodegenerative diseases induced by multiple endogenous and/or exogenous factors. The recent use of transgenic mice, in parallel with other genetic, biochemical and neurobiological systems, in vivo and/or in vitro (cell cultures), should accelerate the discovery and development of specific drugs for the treatment of Alzheimer's disease.     

Genetic and molecular approaches to synthesis and action of the yeast killer toxin

Summary The K1 killer toxin ofSaccharomyces cerevisiae is a secreted, virally-coded protein lethal to sensitive yeasts. Killer yeasts are immune to the toxin they produce. This killer system has been extensively examined from genetic and molecular perspectives. Here we review the biology of killer yeasts, and examine the synthesis and action of the protein toxin and the immunity component. We summarise the structure of the toxin precursor gene and its protein products, outline the proteolytic processing of the toxin subunits from the precursor, and their passage through the yeast secretory pathway. We then discuss the mode of action of the toxin, its lectin-like interaction with a cell wall glucan, and its probable role in forming channels in the yeast plasma membrane. In addition we describe models of how a toxin precursor species functions as the immunity component, probably by interfering with channel formation. We conclude with a review of the functional domains of the toxin structural gene as determined by site-directed mutagenesis. This work has identified regions associated with glucan binding, toxin activity, and immunity.     

重组白细胞介素-13及其受体对小鼠胚胎成纤维细胞增殖及表型转化的影响

将常规培养的NIH3T3细胞分为实验组和对照组,实验组加入80μg/L IL-13,作用24h后进行以下实验:使用RT-PCR技术检测NIH3T3细胞中IL-13Rα1、IL-13Rα2及α-SMA基因的表达;使用MTT法检测NIH3T3细胞的增殖率.研究结果表明:实验组NIH3T3细胞,胞体呈梭型,突起生长迅速,相互交织成网状,与对照组相比形态发生了明显的改变;MTT法测定显示,实验组NIH3T3细胞的增殖率与对照组相比显著增加,差异显著(P0.01);RT-PCR检测IL-13Rα2及α-SMA基因的表达量均显著增加,而IL-13Rα1表达量变化不大.本研究表明IL-13Rα2在成纤维细胞上的表达与其增殖和转型具有直接的相关性,IL-13可直接作用于成纤维细胞并可能以IL-13Rα2为起点发挥致肺纤维化作用.     

滴定分析中固、液体鉻黑T指示剂应用比较

分别采用初配和配制7天后的固、液体铬黑T指示剂标定EDTA溶液及测定水的总硬度,根据实验结果分析两种形态指示剂的使用效果,结果表明,新配制的EBT固、液指示剂,标定EDTA时有显著性差异,测定水的总硬度时,两种指示剂无显著性差异;配制7天后的EBT固、液指示剂,标定EDTA及测定水的总硬度时,使用两种指示剂均存在显著性差异.经F检验,液体铬黑T指示剂放置7天后测定精密度低于新配制指示剂,固体鉻黑T指示剂放置前后测定精密度无显著变化.因此得出结论,若实验时新配制指示剂,选用液态为佳,否则,要使用固体鉻黑T指示剂.     

一个新的可验证多秘密共享方案

提出了一个新的多秘密共享方案,该方案设计思想较参考文献[9]更为简洁清晰,同时又保留了文献[9]的一些优点,所以在实际情况中可被广泛应用.     

推行政府采购对高校图书馆图书采购之利弊谈

论述了图书馆在图书采购中推行政府采购制度的优点及意义，对实践中出现的问题和弊端进行了探讨，提出了相应的解决方法。     

双原子分子光解离截面的含时理论研究

采用含时波包理论中劈裂算符-傅立叶变换方案研究了双原子分子在强场下的光解离吸收截面.得到了与实验相同的结果.在这种方案中,时间演化算符的幺正性保证了波函数在传播过程中的规范性.另外,可以根据实际情况选择一定个数的格点,在一定程度上提高了计算效率.     

Buck－Sukumar模型中原子的量子相干对光场压缩的影响

本文研究了Ｂｕｃｋ－Ｓｕｋｕｍａｒ模型中原子的量子相干对光场压缩的影响，结果表明：原子能级间的量子干涉减弱了光场的压缩效应。     

浅析Excel在现代会计中的运用

介绍了Excel中文电子表格处理软件在现代会计工作中的应用，包括会计报表的编制，财务分析的编制，记账凭证的检索，重点往来款项明细表的编制等。