Co-regulated Protein Functional Modules with Varying Activities in Dynamic PPI Networks

Current methods for the detection of differential gene expression focus on finding individual genes that may be responsible for certain diseases or external irritants. However, for common genetic diseases, multiple genes and their interactions should be understood and treated together during the exploration of disease causes and possible drug design. The present study focuses on analyzing the dynamic patterns of co-regulated modules during biological progression and determining those having remarkably varying activities, using the yeast cell cycle as a case study. We first constructed dynamic active protein-protein interaction networks by modeling the activity of proteins and assembling the dynamic co-regulation protein network at each time point. The dynamic active modules were detected using a method based on the Bayesian graphical model and then the modules with the most varied dispersion of clustering coefficients, which could be responsible for the dynamic mechanism of the cell cycle, were identified. Comparison of results from our functional module detection with the state-of-art functional module detection methods and validation of the ranking of activities of functional modules using GO annotations demonstrate the efficacy of our method for narrowing the scope of possible essential responding modules that could provide multiple targets for biologists to further experimentally validate.     

Cartan型李代数的不可约表示

利用广义限制李代数的概念和性质,研究Cartan型李代数L=X(m,n)(X=W,S,H)的不可约表示,给出了特征标高度h(2≤h相似文献   

WC倾斜模的Auslander Reiten对应

给出了WC倾斜模与满足特定条件的子范畴的一一对应关系, 将倾斜模上的Auslander Reiten 对应推广到了WC倾斜模上。     

优越扩张下GC--投射模

在半对偶模的基础上,针对一个模的G_C-投射性在环的优越扩张下是保持的,在已知结论正确的情况下采用不同于以往的证明方法,利用模的G_C-投射性的等价命题证明主要结论,即对于环的优越扩张R→S和S-模SM,R-模RM是一个G_C-投射模当且仅当SM是一个G_(S■RC)-投射模。使用等价命题后采用的新证明方法逻辑清晰,形式统一,便于模的具体相关性质的推广与应用。     

Virtually正则模

作为正则模的真推广,引入了virtually正则模的概念,研究了这类模的基本性质,证明了环R是(强)virtu-ally正则环当且仅当环R上的每个(投射模)自由模是(半完全)virtually正则模.     

基于SCSO-SVM算法的光伏组件故障识别

光伏阵列通常被安装在恶劣的室外环境中,因此在运行过程中易发生故障。为了准确识别光伏阵列的故障类型,提出沙猫群优化支持向量机(sand cat swarm optimization support vector machine, SCSO-SVM)用于光伏组件故障识别,且对比支持向量机(support vector machine, SVM)、粒子群优化支持向量机(particle swarm optimized support vector machine, PSO-SVM)、遗传优化支持向量机(genetic optimized support vector machine, GA-SVM)、麻雀优化支持向量机(sparrow optimized support vector machine, SSA-SVM)、灰狼优化支持向量机(gray wolf optimized support vector machine, GWO-SVM)和鲸鱼优化支持向量机(whale optimized support vector machine, WOA-SVM)算法。首先,六种SVM混合算法都克...     

左G-正则环

刻画了左G-正则环的结构与性质, 以及T-纯内射模、T-余扭模、τ-内射模之间的关系.     

不可约模的张量积分解

给出了G=Sp(4,K)时,限制支配权所对应的不可约模的张量积分解,这里K是特征数p(0的代数闭域,G是K上C2型单连通半单代数群。确定有限群的Cartan不变量及第一Cartan不变量是模表示论中的重要研究课题,而不可约模的张量积分解对计算李型有限群的Cartan不变量和第一Cartan不变量具有十分重要的意义。利用文献[1]中Mr.HU Yu-wang的WEYL模分解结果(文献[1]),得到限制支配权所对应的不可约模的张量积分解。     

实四元数矩阵方程的广义反对称酉反对称解

利用广义反对称酉反对称矩阵的性质和矩阵的自反逆的理论,得到了实四元数矩阵方程AX=C和矩阵方程组[A1X=C1,A2X=C2]的广义反对称酉反对称解的存在条件及其通解表达式．     

关于矩阵广义逆的几个性质

Magnus和Neudecker曾讨论Moore-Penrose广义逆所具有的“乘积化简”和“加减分拆”等若干较好性质。本文推广得到最小二乘广义逆和最小范数广义逆等也具有这些性质,为其进一步应用提供了方便。