老年甲亢性心脏病误诊分析

老年甲亢性心脏病因症状不典型，易被漏诊或误诊，当患者以“心悸、气短、双下肢水肿”为主诉来诊时，易被误诊为冠心病心力衰竭。本文以临床典型病例加以讨论，总结二者的鉴别要点；分析误诊原因，概括二者治疗差异，供临床工作者参考、借鉴。     

人工智能方法在冠心病诊断中的应用

本文采用人工智能的方法,在诺依曼体系机上模拟人工神经网络,建立疾病诊断模型,并给出实验分析.然后文章提出用遗传算法来优化神经网络结构,从而从整体上提升疾病诊断模型的性能.     

微量元素与冠心病关系的神经网络判定方法

以Cu、Zn、Cr、Cd4种血清微量元素为指标，以76例临床测试数据及临床诊断结果为基础，采用遗传算法构建神经网络模型，并对10例测试数据进行判定，判定结构与临床诊断结果完全一致。结果表明，这一方法可以作为冠心病诊断的有效辅助手段。     

49例冠心病血液流变学检测结果分析

本文对４９例冠心病患者和２１例中老年健康者进行了血液流学六项指标检测并对结果进行了分析。     

大鼠肝郁证所致冠心病心肌超微结构变化的研究

本研究观察了大鼠肝郁证动物模型的心肌细胞超微结构，结果显示实验动物心肌细胞的超微结构出现明显的变化，主要表现为线粒体嵴断裂、疏松，肌原纤维排列紊乱，脂褐素增多等． 这些病理变化为肝郁状态导致冠心病的研究提供了超微形态学上的依据．     

老年人高血压、冠心病血脂检测分析

测定了老年人冠心病56例及高血压病35例血浆TC（胆固醇）、TG（甘油三酯）、LDL－C（低密度脂蛋白胆固醇）、HDL－C（高密度脂蛋白胆固醇）含量,结果显示,老年人高血压、冠心病患者TC、LDL－C均显著高于健康人（P＜0．01）;冠心病患者HDL－C及HDL－C／TC显著低于健康人（P＜0．05,P＜0．01）,高血压组的HDL－C／TC也明显低于健康人（P＜0．05）。提示老年高血压、冠心病患者外周血组织有胆固醇堆积现象。     

Investigation of gene expression profiles in coronary heart disease and functional analysis of target gene

The research outlined here includes constitution of the differential gene expression profile by means of oligonucleotide gene microarray and functional analysis of the target gene for coronary heart disease (CHD). In a microarray screening experiment, the predominance of inflammation- and immune-related genes is presented in the expression profile of 107 differential genes based on the analysis of gene ontology and gene pathway. IL-8, an inflammatory factor, is identified as one of the genes that were markedly up-regulated in CHD. The plasma level of IL-8 is significantly raised in patients with CHD (n = 30) compared with healthy controls (n = 40), which underscores the clinical relevance of the in vitro finding. The further functional analysis shows that IL-8 affects platelet aggregation percentage, expression of CD62p and platelet aggregation morphology in 12 healthy volunteers to some extent. These findings suggest the relevance of inflammation and immune responses to CHD at the DNA level. Moreover, IL-8 may be involved in the pathogenesis of CHD through the pathway of platelet activation. Supported by the National Natural Science Foundation of China (Grant No. 90409021)     

An effective algorithm for needle tip displacement compensation in robot-assisted percutaneous surgery

This paper presents an automatic compensation algorithm for needle tip displacement in order to keep the needle tip always fixed at the skin entry point in the process of needle orientation in robot-assisted percutaneous surgery.The algorithm, based on a two-degree-of-freedom (2-DOF) robot wrist (not the mechanically constrained remote center of motion (RCM) mechanism) and a 3-DOF robot arm, firstly calculates the needle tip displacement caused by rotational motion of robot wrist in the arm coordinate frame using the robotic forward kinematics, and then inversely compensates for the needle tip displace-ment by real-time Cartesian motion of robot arm.The algorithm achieves the function of the RCM and eliminates many mechanical and virtual constraints caused by the RCM mechanism.Experimental result demonstrates that the needle tip displacement is within 1 mm in the process of needle orientation.     

Biomedical Engineering Approach to Evaluate Anastomosis Methods for Coronary Artery Bypass Grafting

There are two different methods for coronary artery bypass grafting: end-to-side and side-to-side anastomosis. In vitro mock test, flow visualization and animal experiments were performed in parallel to compare the hemodynamic effect between two methods. Thus, bioengineers can provide practical useful information to the clinical team.