叠腿的遗传学分析

对163对同性别双生子的叠腿方式进行分析．结果表明,叠腿主要与遗传因素有关．采用Smith无偏分析法及刘祖洞理论子女总数校正法对72个家系资料的分析发现．叠腿可能为常染色体单基因遗传,叠腿右型相对于左型为显性性状．此外．虽然遗传因素对该性状起主要作用,但环境因素对其表型也有一定影响．     

Family I.3 lipase: bacterial lipases secreted by the type I secretion system

Based on the classification of bacterial lipolytic enzymes, family I.3 lipase is a member of the large group of Gram-negative bacterial true lipases. This lipase family is distinguished from other families not only by the amino acid sequence, but also by the secretion mechanism. Lipases of family I.3 are secreted via the well-known type I secretion system. Like most of proteins secreted via this system, family I.3 lipases are composed of two domains with distinct yet related functions. Recent years have seen an increasing amount of research on this lipase family, in terms of isolation, secretion mechanism, as well as biochemical and biophysical studies. This review describes our current knowledge on the structure-function relationships of family I.3 lipase, with an emphasis on its secretion mechanism. Received 18 April 2006; received after revision 3 July 2006; accepted 24 August 2006     

MPTP慢性帕金森病小鼠海马内氧化应激与细胞凋亡蛋白的表达

目的 观察 MPTP慢性帕金森病小鼠海马氧化应激指标及细胞凋亡相关蛋白的表达.方法 应用MPTP制备慢性帕金森病模型,观察行为学改变,Morris水迷宫实验,检测模型组和对照组小鼠海马内超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）及丙二醛（MDA）舍量变化,以及免疫组织化学方法、RT-PCR方法、Western blot方法检测海马Bax和Bel-2蛋白表达.结果 慢性帕金森病模型小鼠行为学特点为震颤、活动减少;水迷宫实验结果提示认知功能降低;与对照组海马比较：模型组海马SOD、GSH含量均下降,而MDA含量升高（P〈0.05）;模型组海马Bax蛋白表达增高,而Bel-2蛋白表达下降（P〈0.05）.结论 氧化应激在慢性帕全森病认知功能障碍发病机制中起重要作用,而Bax和Bcl-2蛋白参与了氧化应激诱导海马神经元凋亡的调控过程.     

四川资阳汉族7项不对称行为特征的研究

以四川省资阳地区作为取样点,调查了497例(男220例,女277例)简阳市汉族高中生的7项不对称行为特征(扣手、利手、叠臂、叠腿、利足、起步类型和优势眼).研究结果显示:(1)四川资阳汉族7项不对称行为特征出现率均R型高于L型.(2)四川资阳汉族7项不对称行为特征的出现率均不存在性别间差异.(3)四川资阳汉族与蒙古族等12个民族R型率比较,经u检验显示,除藏族外,与其他12个民族均有4项及以上不对称行为特性与其出现显著差异.(4)与其他7个地区汉族人群比较的u检验显示,四川资阳汉族与其他6个地区汉族均有3项以上不对称行为出现显著差异.(5)分析了四川资阳汉族7项指标间的相关性,发现扣手与利足、扣手与起步、利手与利足、利手与起步、叠腿与利足、叠腿与起步、利足与起步也存在显著的相关性,且R-R型组合(右型-右型)的出现率远高于L-L型组合(左型-左型)的出现率.     

Nb对Li／MgO甲烷氧化偶联催化剂的助催化作用

Ｌｉ／ＭｇＯ甲烷氧化偶联催化剂引入铌的氧化物可降低活性温度，７５０℃以下便达到最高Ｃ２烃产率。铌与锂、镁有多种结合方式，引入方法对活性测试结果有重要影响。铌不与镁紧密结合且分布于锂、镁之间时作用最好。     

瞬变应答法研究丁烯氧化脱氢的反应机理

在铁系催化剂上研究了文题的反应机理。通过瞬变应答实验和对响应曲线的分析,证实丁烯、丁二烯和氮在催化剂上发生竞争吸附,其反应机理是吸附氧和吸附丁烯间进行的Langmuir-Hinshelwood型机理,反应的控制步骤是氧吸附控制。瞬变应答实验也揭示出催化剂表面状态存在滞后特性,反应速率和选择性与预处理条件有关。     

B90催化剂上丁烯氧化脱氢的反应动力学─一一种简便的建立化学动力学方程的方法

采用简便的建立化学反应动力学方程的方法，研究了Ｂ９０催化剂上丁烯氧化脱氢制丁二烯反应的动力学，即先在一较低温度下，用微分法拟合得到化学反应动力学方程中的浓度项，然后改变反应温度，求算不同温度下的反应速率常数。采用这个简便方法，只需较少的实验，即可求得该反应体系中的丁烯转化速率方程式。     

sHsps and their role in the chaperone network

Small Hsps (sHsps) encompass a widespread but diverse class of proteins. These low molecular mass proteins (15—42 kDa) form dynamic oligomeric structures ranging from 9 to 50 subunits. sHsps display chaperone function in vitro, and in addition they have been suggested to be involved in the inhibition of apoptosis, organisation of the cytoskeleton and establishing the refractive properties of the eye lens in the case of α-crystallin. How these different functions can be explained by a common mechanism is unclear at present. However, as most of the observed phenomena involve nonnative protein, the repeatedly reported chaperone properties of sHsps seem to be of key importance for understanding their function. In contrast to other chaperone families, sHsps bind several nonnative proteins per oligomeric complex, thus representing the most efficient chaperone family in terms of the quantity of substrate binding. In some cases, the release of substrate proteins from the sHsp complex is achieved in cooperation with Hsp70 in an ATP-dependent reaction, suggesting that the role of sHsps in the network of chaperones is to create a reservoir of nonnative refoldable protein.     

Offlattice Model in the Prediction of Protein 3D Structure

3-dimension HPNX offiattice model is developed from the 2-dimension HP offiattice model. In the HP model, 20 types of amino acid monomers are divided into two classes, H （non-polar monomer） and P （polar monomer）. In the HPNX model, polar monomers are split into positively charged （P）, negatively charged （N） and neutral （X） monomers. A new evolutionary algorithm is applied to study long chains of the HPNX offiattice protein model. This method successfully predict the structures of several proteins in the 3-dimension space that are similar to the structures gotten by X-Ray Crystallography and NMR and published in the PDB（Protein Data Bank）.