Effect of volatile anesthetics on the circular dichroism of bilirubin bound to human serum albumin

The characteristic circular dichroism of bilirubin bound to human serum albumin undergoes a remarkable sign inversion on addition of halothane, chloroform and other volatile anesthetics. This sign inversion, which is completely reversed by removal of the anesthetic, reflects a pronounced conformational change of the bound ligand; probably a complete inversion of chirality. The observation suggests that association of volatile anesthetics with proteins can markedly alter the internal topography of receptor sites and potentially influence the stereoselectivity of ligand binding.     

Cell-to-cell coupling studied in isolated ventricular cell pairs

Summary Cell pairs isolated from adult rat and guinea pig ventricles were used to study the electrical properties of the nexal membrane. Each cell of a pair was connected to a voltage-clamp system so as to enable whole-cell, tight-seal recording. The current-voltage relationship of the nexal membrane was found to be linear, revealing a resistance r_n of 2–4 M. r_n was insensitive to the sarcolemmal membrane potential (range:–90 to +30 mV), and exerted no time-dependent gating behavior (range: 0.1 to 10 s). Lowering pH_i yielded a small increase in r_n. Vigorous elevations in [Ca²⁺]_i gave rise to an increase in r_n which was associated with a cell shortening. Uncoupling caused by aliphatic alcohols or halothane did not produce cell shortening. Cell pairs were also used to study action potential transfer.     

Studies of a key protein in the mechanism of the excitation-contraction coupling process of frog skeletal muscle,using phenylglyoxal

The excitation-contraction (E-C) coupling process in single twitch fibres from frog toe muscle was inhibited selectively by phenylglyoxal (PGO), a specific guanidyl modifying reagent. A new protein (31.5 kDa), which has PGO-binding ability and seems to play a key role in the E-C coupling process, was solubilized from transverse tubule membrane-junctional sarcoplasmic reticulum complexes (TTM-JSR) of frog skeletal muscles, using¹⁴C-PGO. The monoclonal antibody against this protein applied extracellularly inhibited the E-C coupling process of the single fibres. This protein appears to constitute the very first step of input for E-C coupling. It is considered to behave as an indispensable part of an electrometer to measure membrane potentials. Therefore, the name electrometrin is suggested for the new protein.     

时间相关的含缺陷材料的流变破坏理论

含缺陷物体的与时间相关的失效过程是一个热力学开放的，远离平衡态的系统，失效过程中发生耗散结构的自组织现象，不同尺度上耗散结构的自相似性可供从微观过度到细观和宏观，基于缺陷演化过程国局域温度场和热磁效应的实验研究，从统一的宏、细、微观层次体系出发。研究了与时间相关的缺陷体的失效过程，结果表明。这个失效过程并非纯力学过程，其中的热力耦合和热磁效应不容忽略。     

E(×)e系统耦合性质初步研究

使用幺正转化方法对E(×)e系统的绝热势能进行计算,得到势能面的最低槽,对二次耦合项所引起的绝热势能面的变形做初步探讨;利用Mathematica软件对该系统能量和线性耦合强度的函数关系做数学模拟.与求解繁琐的声子态方法相比,该方法不仅减少了计算量,而且更能体现出相关参量的物理含义.     

多发串联有控发射武器系统内弹道物理过程

该文根据多发串联预装填有控发射方式武器系统的工作原理，提出了拟静力燃烧时期、拟内弹道过程、强耦合、弱耦合及非耦合等概念，详细分析了多发串联预装填有控发射方式武器系统内弹道物理过程，为多发串联预装填有控发射方式武器系统内弹道控制研究提供了理论依据。     

层间耦合对双层铁磁薄膜中自旋波共振禁闭模及共振的影响

对双层铁磁薄膜构成的系统，考虑界面铁磁性和反铁磁性耦合x寸自旋波色散关系、波形演化及共振的影响．结果表明：层间耦合对自旋波的共振影响较大，即层间铁磁性耦合比反铁磁性耦合更易发生共振．     

用模糊聚类分析法建立神经网络岩土本构模型

针对岩土类材料本构关系复杂的情况 ,采用BP网络建立了其本构模型 ,并从神经网络隐层的本质特征出发 ,对样本数据 (应力和应变信息 )采用模糊聚类分析法进行特征抽取 ,以确定隐层节点数目 .算例结果表明 ,该方法是可行的 ,并具有较直观的物理意义 ,可为样本的选取提供指导作用 .     

大规模复杂换热网络联动进化障碍分析及策略改进

针对启发式算法在优化大规模换热网络时出现优化精细度不足的问题,提出一种以小负荷公用工程为导向的换热单元耦合联动强制进化策略。该策略以小负荷公用工程作为导向,构建具有耦合关系的换热单元环路,并对环路内的换热单元热负荷进行联动调整,同时保持环路外换热单元的热负荷和流股匹配不变。该策略旨在最大程度回收流股的能量,以减少小负荷公用工程使用带来的费用增加。将策略应用于强制进化随机游走算法并对两个算例进行测试,算例H8C7和H10C10的优化结果分别为1495292 $/a和1713637 $/a。与改进前相比,分别降低了7466 $/a和7533 $/a;与文献中最优解相比,分别减少了2033 $/a和1450 $/a,证明了该策略的有效性。     

弹载消旋平台双模控制与仿真研究

为了消除弹体转动对惯性平台及天线运动耦合的影响,设计了旋转导弹消旋平台,并将模糊控制器与常规PID相结合,建立消旋平台Fuzzy-PID双模控制仿真模型。采用MATlAB和MATlAB/ADAMS联合仿真方法对消旋平台双模控制系统进行仿真分析。结果表明,Fuzzy-PID双模控制使惯性平台及天线的稳态性能得到明显改善。