DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice

Clinical observations indicate that DanHong Injection （DHI） can increase blood flow and reduce various syndromes in patients with cardiovascular disease. How- ever, it still needs to define the function of DHI and the involved mechanisms in details, such as the protective effect on the development of primary abdominal aortic aneurysms （AAAs）. In this study, we determined whether DHI is able to inhibit AAA in apoE knockout （apoE-/-） mice. Thirty apoE-/- male mice on high-fat diet （0.5 % cholesterol, 21% fat） were randomly divided into two groups and received i.p. injection of saline （100 μL/day） and DHI （100 μL/day）, respectively, for 16 weeks. At the end of experiment, we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall, and serum lipid levels. We also determined the expression of monocyte chemoattractant protein-1 （MCP-1）, MMP-2, and MMP-9 mRNA in aortic wall using real-time RT-PCR. Our results indicated that high-fat diet induced the development of AAAs in apoE-/- mice, but the induction was totally blocked by DHI （P 〈 0.01）. The result of staining of abdominal aortic cross sections showed that DHI main- tained the collagen content in arterial wall, thereby pre- venting the animals from the development of AAA. Although DHI had little effect on serum total- and LDL- cholesterol levels, it reduced the expression of MCP-1, MMP-2, and MMP-9 mRNA in aortic wall （P 〈 0.01）. Taken together, our study suggests that DHI can inhibit the high-fat diet-induced AAA formation. The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes. Our study may suggest a new application of DHI in clinics.     

消费品生命周期隐患识别与风险评价的三维矩阵方法

面对近年我国产品质量安全事故频发、消费者人身安全与健康遭受不同程度的威胁以及出口产品不时被召回或退回的问题，给出了一种基于消费品生命周期和事故致因的隐患识别及表征方法，有助于提升人们对消费品危害规律的认知水平并为消费品风险评价奠定基础. 考虑到事故伤害受体的能力和行为会对消费品缺陷或隐患演化及事故伤害后果产生重要影响，在常规风险评价二维矩阵的基础上，加入风险受体的脆弱性要素，提出了消费品风险评价的三维矩阵方法，能够更好地表征消费者能力与行为等主观要素对消费品隐患事故及危害的影响作用. 以家用电器风险评价为例，基于欧盟非食品类消费品快速预警系统（RAPEX）对中国消费品通报信息分析和专家评价打分，形成了消费品评价三维风险矩阵，分析了家用电器的风险规律，为消费品的风险评价提供了新思路、新方法.     

Synthesis of the 3D porous carbon-manganese oxide (3D-C@MnO) nanocomposite and its supercapacitor behavior study

A 3D porous carbon-manganese oxide ([email protected]) nanocomposite is successfully synthesized via a thermal plasma deposition method. The chemical bonds and compositions, phase structures, surface morphologies, etc. of as-obtained [email protected] nanocomposite were characterized by the various equipment, such as X-ray diffractometer, X-ray photoelectron spectroscopy, and electron microscopes. The electrochemical performances of the [email protected] nanocomposite electrode showed a specific capacitance of 780 F g^?1 at a current density of 2 A g^?1 and a capacitance retention rate of 99% after 5000 charge-discharge cycles at a high current density of 10 A g^?1. These excellent capacitive performances may be attributed to the encapsulation of MnO nanoparticles by porous carbon sheets in the [email protected] MnO nanocomposite structure. It is believed that the carbon-encapsulated MnO nanoparticles can be protected from a volume deformation during the charge adsorption/desorption cycle and can be electrically improved by the encapsulated carbon sheets, resulting in better overall capacitive performance. In addition, this study also demonstrates the practical applicability by assembling a supercapacitor using the as-obtained [email protected] nanocomposite to glow a light emitting diode.     

血浆sST2联合NT-proBNP对急诊心衰患者生存状况的预测价值

目的探讨血浆sST2联合NT-proBNP对急诊心衰患者生存状况的预测价值.方法选择急诊心衰患者130例,分为心功能Ⅱ级组、心功能Ⅲ~Ⅳ级组,对照组选择健康的体检者60例.对3组NT-proBNP及血浆sST2水平进行观察对比,对心功能不同分级患者NT-proBNP及血浆sST2水平进行比较,比较NT-proBNP,sST2,NTproBNP联合血浆sST2对心衰患者死亡状况的预测价值.结果随心功能分级递增,NT-proBNP水平逐渐升高,sST2曲线下面积(0.776)及NT-proBNP对死亡判定的ROC曲线与NT-proBNP曲线下面积(0.775)相比较没有明显差异,但二者联合曲线下面积为0.813,与NT-proBNP及sST2曲线下面积相比较差异显著.sST2联合NTproBNP进行心衰患者死亡状况预测时的敏感度为99.0%,特异度为93.2%.结论作为急诊心衰患者诊断、预后和风险评估的主要标志物,sST2联合NT-proBNP对患者生存状况进行评估可以很好地预测患者的生存状况,提高准确度和敏感度,值得在临床上推广应用.     

实时三维超声心动图与二维斑点追踪成像技术共同评价心肌梗死患者左室收缩功能与同步性

目的探讨二维斑点追踪成像(2D-STI)及实时三维超声心动图(RT-3DE)评价AMI患者左心室收缩功能和各节段运动的同步性.方法 50例急性心肌梗死患者为病例组,30例正常体检者为对照组,应用CMQ软件获取各节段径向圆周应变及应变率曲线,然后转变为RT-3DE模式,得到17节段时间-体积曲线(VTC),并获得收缩功能以及非同步收缩参数.结果 1)与对照组相比,心肌梗死组3个水平所有节段径向应变值和圆周应变值均减低;2)心梗组患者Trs-SD,Tcs-SD,Trsr-SD,Tcsr-SD明显高于对照组(P0.05);3)与单支冠状动脉病变心梗组比较,多支冠状动脉病变心梗组LVEDV,LVESV显著增加,LVEF显著减小;4)病例组患者左室Tmsv17-SD,Tmsv17-Dif,Tmsv17-SD%,Tmsv17-Dif%均较对照组增大(P0.05).结论 RT-3DE和2D-STI可以准确地量化左室收缩功能,评价AMI患者左室运动的同步性,左室收缩功能障碍也影响收缩同步性.     

COD测定废液中Ag2S04的回收循环利用研究

目的研究COD测定废液中Ag2SO4的回收和利用，实现资源的循环利用，提高利用效率，节约实验成本，减少环境污染。方法以COD测定废液为研究对象，将Ag2SO4通过NaCl转化为AgCl沉淀，再用Zn粒在酸性介质中进行还原，使AgCl转化为银粉；所得银粉在少量HN03存在的条件下，用浓H2S04氧化，将其转化为Ag2SO4，重新用于COD测定实验。结果通过一系列实验研究表明，有70％的银可以得到回收，所得Ag2SO4再次用于COD测定实验，标准样品的COD测定误差在许可范围之内；实际污水中COD的测定实验结果表明，Ag2SO4循环使用的测定误差平均为7．4％。结论实验证明回收的Ag2SO4可以作为COD测定实验的催化剂循环使用，可操作性良好，在节约实验成本的基础上，对于环境保护、减少污染物排放量方面有显著效果。但是COD测定结果的偏差较大，重现性有待进一步改进提高。     

Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains unclear.Thus,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in vivo.HBJ significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 cells.Furthermore,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 cells.In addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in mice.Consistently,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated control.Collectively,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.     

HCOOH在电极Pd(110)表面电吸附的密度泛函研究

采用密度泛函理论和周期平板模型相结合方法,对HCOOH分子在Pd(110)表面bridge,bidentate和unidentate三种形态吸附位进行吸附结构、Mulliken布居和振动频率等性质的计算;计算结果表明HCOOH在金属态表面bidentate为最稳定的吸附位,电极表面unidentate为最稳吸附位;HCOOH在电极表面的吸附远大于金属态表面的吸附能,表明电化学反应比普通化学反应容易进行.电极表面吸附的结构和频率分析显示,吸附过程中O—H、C—H键均伸长,v(O—H)键和v(C—H)振动频率均发生明显红移,表明H原子在吸附过程中容易断裂,脱离HCOOH分子.Mulliken电荷布居分析表明在电吸附过程中电子由HCOOH分子向Pd(110)表面进行转移,有利于电催化反应进行.     

力触觉增强的虚拟现实工厂系统

现有虚拟现实工厂只能依靠头戴式显示器和手柄进行单向的视、听觉虚拟操作，难以进行双向的沉浸式触觉交互。针对此问题，采用力反馈控制器设计了一种力触觉增强的虚拟现实工厂系统。以Unity3D为基础，采用3DMax对工厂内多类型工具和零部件进行三维视觉建模，并通过反射探针、光照探针等组件进行立体化视觉增强。在此基础上，为虚拟空间物体增加刚体、碰撞体、关节等组件，建立虚拟空间的触觉反馈模型，实现了力反馈控制器与虚拟空间物体的实时触觉交互。实验表明：系统可提供重力、摩擦力、恒力等多种力触觉感知，支持对20余种工具、零部件的触摸、抓取等触感操作，能感受模型、轮廓以及质量等物理属性，实现了虚拟工厂中“视触听”多维立体化的沉浸式操作。     

苯并[1，2-b：4，5-b’]二噻吩-thieno[3，4-易]thiadiazole导电性的理论研究

采用密度泛函理论，在B3LYP／6—31G（d）水平下，对苯并[1，2-b：4，5-b’]二噻吩（BDT）-thieno[3，4-b]thiadiaz01e（TD）的低聚物和聚合物进行了理论计算．其中，BDT为电子供体，TD为电子受体，以1：2的方式结合形成化合物，并计算了二面角、分子内的电荷传输、桥键键长和中心键电荷密度．结果显示：随着聚合链增长，共轭程度增加．NICSs值显示：中心环比边环的共轭程度更大．聚合物的能带结构表明：该聚合物的带隙比较低（0．87eV），故其可以作为潜在的导电材料．