为钟南山更名“非典”叫好

2002年底震惊世界的一件大事，就是在国内外许多地方发生了一种突发性的危害极大的新型肺炎，其紧急性、未知性以及传播速度快等特点，使人们来不及研究，为其确定一个准确的名称，致使前后有十几种叫法(或意见)，例如“原因不明肺炎”、“非典型肺炎”、“非典”、“传染性非典型肺炎”、“急     

SARS epidemical forecast research in mathematical model

The SLJR model, simplified from the SEIJR model, is adopted to analyze the important parameters of the model of SARS epidemic such as the transmission rate, basic reproductive number. And some important parameters are obtained such as the transmission rate by applying this model to analyzing the situation in Hong Kong, Singapore and Canada at the outbreak of SARS. Then forecast of the transmission of SARS is drawn out here by the adjustment of parameters (such as quarantined rate) in the model. It is obvious that inflexion lies on the crunode of the graph, which indicates the big difference in transmission characteristics between the epidemic under control and not under control.This model can also be used in the comparison of the control effectiveness among different regions. The results from this model match well with the actual data in Hong Kong, Singapore and Canada and as a by-product, the index of the effectiveness of control in the later period can be acquired. It offers some quantitative indexes, which may help the further research in epidemic diseases.     

科学面对"非典"

一、传染性非典型肺炎的特点和传播途径 传染性非典型肺炎,原来叫非典型肺炎,简称"非典",是指最近发生的,目前病原还没最后确定的一种传染性肺炎.世界卫生组织建议称其为"严重急性呼吸道综合征"(Severe Acute RespiratorySyndromes),简称SARS.典型性肺炎通常是指由肺炎链球菌等常见细菌引起的肺炎.症状比较典型,如发烧、胸痛、咳嗽、咳脓痰等,血常规化验白细胞通常会增高.非典型肺炎,是指由病毒、支原体、衣原体、立克次体和军团菌等引起的肺炎.其临床表现多为干咳,相对典型性肺炎来说症状不典型.     

SARS对安徽经济的影响

今年第一季度安徽省经济发展表现出良好的势头,增长速度明显加快,一季度增长11.4%,这是自1998年以来首次达到两位数水平,"拐点"似乎已到.国民经济初步呈现了速度、结构、质量和效益的协调统一.     

国际医药巨头整合资源研究非典疫苗

法国巴斯德研究所日前与英国葛兰素史克生物医药公司签订合作协议,拟共同研发非典疫苗。此间舆论认为,这标志着国际医药巨头已进入整合资源共同研究非典疫苗的阶段。巴斯德研究所是世界最大的疫苗研制生产机构,近来以该研究所为首的几大国际医药企业关于非典疫苗研究的举措连连。究其原因,是这些企业意识到各自为战研究疫苗的过程是艰巨而漫长的,而以合作的方式进行资源整合,可以实现优势互补,并共享市场。目前这种资源整合主要呈两种趋势,即医药巨头联合研制,以及医药巨头与有关国家科研机构密切合作。巴斯德研究所与全球最大的制药公司之…     

A complete sequence and comparative analysis of a SARS-associated virus （Isolate BJO1）

The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-assoclated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs.We report the complete genome sequence and comparative analysis of an isolate (B J01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 20RFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS-associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to be involved in the immunoreactions between the virus and its host.Two amino acid changes have been detected in the M protein,which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides no evidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of other possible SARS-related pathogen(s).     

Bioinformatical study on the proteomics and evolution of SARS-CoV

A novel coronavirus has been identified as the causative agent of the severe acute respiratory syndrome (SARS). For all the SARS-CoV associated proteins derivated from the SARS-CoV genome, the physiochemical properties such as the molecular weight, isoelectric point and extinction coefficient of each protein were calculated. The transmembrane segments and subeellular localization (SubLoeation) prediction and conserved protein motifs search against database were employed to analyze the function of SARS-CoV proteins. Also, the homology protein sequence alignment and evolutionary distance matrix calculation between SARS-CoV associated proteins and the corresponding proteins of other coronaviruses were employed to identify the classification and phylogenetic relationship between SARS-CoV and other coronaviruses. The results showed that SARS-CoV is a novel coronavirus which is different from any of the three previously known groups of coronviruses, but it is closer to BoCoV and MHV than to other coronaviruses. This study is in aid of experimental determination of SARS-CoV proteomics and the development of antiviral vaccine.