ICP-AES比较临床分离药物敏感和耐药结核分枝杆菌的金属离子

利用现在多元素痕量分析最重要的方法——电感耦合等离子体原子发射光谱(ICP—AES)分析结核分枝杆菌中的金属离子的种类和含量,结果表明,Cr^3 ,Al^3 ,Ca^2 ,Fe^2 ,Mn^2 ,Co^2 ,Cu^2 ,Ni^2 的含量较高,并发现药物敏感菌株和耐药菌株之间在金属离子种类和含量上有明显区别．这种差异在耐药中的意义有待进一步研究．     

Study of β—amyloid adsorption and aggregation on graphite by STM and AFM

The scanning tunneling microscopy(STM) and the atomic force microscopy(AMF) have been applied to the direct study of the adsorption and aggregation of β-amyloid(1-42)(Aβ42)on the hydrophobic graphite surface.It was found that Aβ42 were preferentially adsorbed on graphite defects such as the edges.Aβ42 peptides self-assembled into intermediate protofibrils,which in turn self-associated to form fibrils.Usually,two or more fibrils intertwined to form the helical structure.These results will provide an important clue to studying the aggregation process of β-amyloid.     

辣椒生产巧用植物生长调节剂(中)

4.芸薹素内脂.又称油菜素内脂,简称BR,主要剂型为0.01%芸薹内脂乳油.辣椒全生育期可喷洒3～5次,开花至盛果期喷2～3次,隔15天1次.在发生病毒病、裂果病及僵苗病后,可连喷2～3次.在施用BR时,应按兑水量的0.01%加入表面活性剂(如吐温20,X-77等),以促进药物的吸收.     

浅谈近年艾滋病的研究进展

目前,艾滋病依然是人类无法攻破的绝症。近年来,经研究发现,HIV病毒的传播途径得到扩大,加上其突变率高,药物更新成为迫在眉睫的要求。本文总结了近年来艾滋病研究的进展,包括药物靶点的开发,疫苗的制作要求以及提出了具有研究前景的抗HIV相关的基因和蛋白,以引起关注。     

应用化学专业《药物化学》课程的教学改革与实践

结合理工类应用化学专业<药物化学>课程的特点,通过进行教学内容的改革、教学方法的改革、实践教学的改革、运用现代化的教学手段等一系列课程的教学改革与实践,达到培养高素质药学专业人才的目标.     

Studies on molecular interactions between puerarin and PC liposomes

Fluorescence emission spectra, FTIR spectra, zeta potential measurements, and ab initio quantum calculation are used to study the interaction between puerarin and membranes composed of egg phosphatidylcholine (PC) liposome. The hydrophobic interactions cause the puerarin molecule to partition into lipid bilayers with its B-ring, and favor the displacement of acid-base equilibrium of puerarin towards the base form. Due to the hydrogen bond formation between the puerarin hydroxyl groups and polar groups of PC molecules on the water/membrane interface, puerarin can easily intercalate into the organized structure of phospholipids and modulate the membrane function. Our results reveal that the liposome membrane integrity is significantly higher compared with that of empty liposome.     

Dialdehyde starch nanoparticles： Preparation and application in drub carrier

Dialdehyde starch nanoparticles (DASNP) were prepared by the redox reaction of NaIO4 and starch in water-in-oil microemulsion. IR spectrum showed that DASNP had aldehyde groups, and quantitative alkali consumption showed that its dialdehyde content was about (50±5)%. The average diameter of DASNP determined by SEM was about 100 nm. TGA-DTA showed that its thermal stability was better than starch nanoparticle (StNP) and dialdehyde starch (DAS). Its low biological toxicity was detected by cell experiment. Also the best mass ratio of doxorubicin (DOX) to combined DASNP detected by UV-VIS was 15 : 1, and the product was effective for controlled release of DOX. The cell experiment showed that the drug-carrier particle (DOX-DASNP) can release DOX for a long time and strengthened the effect of the anticancer drug. This work demonstrates that the DASNP, which has good thermal stability, small particle size, low biological toxicity, and slowly anticancer drug-releasing to strengthen drug effect, is a potentially useful carrier for anticancer drug.     

脐血输注在恶性肿瘤化、放疗中作用的初步探讨

脐血输注作为恶性肿瘤患者化、放疗后的辅助支持治疗，具有明显促进骨髓功能恢复、改善生活质量、提高免疫功能的作用。作者收集该院１９９１年５月～１９９６年１２月接受脐血输注资料较完整的１３６例恶性肿瘤患者病例材料，进行回顾性分析，报告如下：１一般资料全部病例均为病理组织学或细胞学确诊的各种恶性肿瘤患者，设接受脐血输注的１３６例为治疗组，其中肺癌４２例（男３８，女４）；食道癌３２例（男３０，女２）；胃癌１６例（男）；乳腺癌１５例（男１，女１４）；鼻咽癌１０例（男８，女２）；淋巴瘤４（男）；直肠癌３例（男…     

老年痴呆症的药物治疗进展

老年痴呆症（ＡＤ）是一种神经退行性疾病，至今病因未明，且尚无特效药，近年来，临床运用促智药、胆碱酯酶抑制剂、乙酰胆碱释放增强剂、ＮＳＡＩＤ、神经生长因子等药物，对改善症状、延缓疾病表一定的作用。此病的病因及药的治疗有待作更深入的研究 。     

治疗心血管病的毒气

硫化氢 设想一下当走进医院急诊室，映入眼帘的是挂着消毒洗手液、表面擦得一尘不染的墙壁，扑鼻而来的却是一阵臭鸡蛋味。这种视觉和嗅觉上的不协调可能会让人们感到不舒服，但在将来具有臭鸡蛋气味的有毒气体硫化氢很可能会成为医疗机构的常用药物。科学家在去10年间发现，