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21.
Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen
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It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoidesfarinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases. 相似文献
22.
首先分析了Mogi模型的经典最小二乘反演由于出现矩阵奇异或接近奇异而发散的局限性,决定采用具有全局高效搜索性和优化计算时不需要求导的遗传算法来反演火山区压力源参数。反演程序调用Matlab7.0 Release14工具箱中的选择、交叉和变异等相关程序。最后应用该程序和长白山天池火山区水准和GPS观测资料联合反演火山区压力源参数,经过比较遗传算法和阻尼最小二乘方法的反演结果,可看出2种方法结果近似,可见此方法方便快捷地实现了目标函数的最小化。 相似文献
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序列模式挖掘是数据挖掘的重要分支,GSP算法与PSP算法是序列模式挖掘中的两种典型算法。本文介绍了这两种算法并对其进行了分析与比较。 相似文献
25.
Finding finer functions for partially characterized proteins by protein-protein interaction networks
LI YanHui GUO Zheng MA WenCai YANG Da WANG Dong ZHANG Min ZHU ding ZHONG GuoCai LI YongJin YAO Chen WANG Jing 《科学通报(英文版)》2007,52(24):3363-3370
Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins. 相似文献
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六自由度飞行模拟器体感模拟算法及仿真实现 总被引:9,自引:0,他引:9
针对国内首台直九飞机六自由度模拟器,研究了与之相应的体感模拟算法,并应用MATLAB及VC 建立了模型。在此模型的基础上,对一组实际飞行数据进行了仿真计算和分析。结果表明,该算法为充分发挥六自由度模拟器模拟能力提供了一种有效的方法。 相似文献
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数据加密的密码体制与DES算法 总被引:1,自引:0,他引:1
本文论述了保密通信中数据加密的密码体制,并对各种体制地行了比较,指出其优劣,重点论述了数据加密标准DES的算法和特点. 相似文献
30.
估计两个单属性关系在连接属性上取相同值的个数的方法有两种:静态估计法和动态估计法.本文利用不精确性推理模型对这两种方法的可信度定量地进行讨论,并用具体例子进行说明. 相似文献