β-桉烯和其衍生物的合成及其抗生育活性

本文叙述了倍半萜类化合物——β-桉烯、衍生物Neointermedeol以及1,2,3,4,7,8-六氢-5,8-二甲基-3-异丙烯基萘的合成。初步药理筛选结果表明,这三个化合物均具有一定的抗生育活性。化合物还未见报道,它的化学结构在本文得到证实。     

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.     

Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells

Summary Insulin stimulation of glycogen synthesis was nearly abolished in hepatoma cells shortly treated with 4 ß-phorbol 12 \-myristate, 13 -acetate (protein kinase C activation) but remained unmodified in cells chronically treated with the phorbol ester (protein kinase C depletion). Thus, although exogenous activation of protein kinase C results in an inhibition of insulin action, protein kinase C depletion has no influence on this process. The results suggest that, in hepatoma cells, no endogenous activation of protein kinase C may occur in response to the signal triggered by insulin.     

In vitro protein synthesis and α amylase activity in F cells from hepatopancreas ofPalaemon serratus (Crustacea; Decapoda)

In crustaceans, all the steps in the assimilation of food take place in the hepatopancreas. To facilitate the study of this organ, a method for the dissociation of cell types was developed. The hepatopancreas of the prawnPalaemon serratus was mechanically dissociated and the cells separated by Percoll density-gradient centrifugation. The E and R cells had similar densities of around 1.05 g/ml. The F cells were separated into two distinct fractions with densities of 1.075 and 1.082 g/ml. The B cells sedimented at a density of 1.12 g/ml. The ratio between the two populations of F cells was found to vary during the intermolt cycle while B cells disappeared after the molt. When the density gradient fractions were incubated with³H-leucine, incorporation was highest in the F cell fractions. Measurements of -amylase activity, indicated that the two populations of F cells may be derived from the same cell type.     

Sex pheromone of the pine sawflyDiprion pini (Hymenoptera: Diprionidae): Chemical identification,synthesis and biological activity

The main component of the sex pheromone secretion of femaleDiprion pini L. (Hymenoptera: Diprionidae) from insects collected both in Finland and in France has been identified as athreo-3,7-dimethyl-2-tridecanol (8 ng per female) stereoisomer by GC-MS and synthesis. The secretion also contains lower and higher homologues in small amounts (1–4% of the main component). Combined gas chromatographic-electroantennographic detection showed activity in both natural and esterified extracts (acetates and propionates); the esters of the main component gave the largest responses. The acetates and propionates of the eight stereoisomers of 3,7-dimethyl-2-tridecanol were synthesized from enantiomerically highly enriched (>99% ee) building blocks. The stereochemistry of the main component was established to be (2S,3R,7R)-3,7-dimethyl-2-tridecanol by GC analysis of the natural material. It was purified by liquid chromatography prior to the GC analysis of both its pentafluorobenzoates and its isopropylcarbamates on a non-chiral polar column (ECD) and a chiral column (NPD), respectively. Field tests demonstrated that both the acetate and propionate of the main component (100 g of each applied on cotton roll dispensers) were active in attracting males, with or without the presence of several of the minor compounds. Experiments with smaller amounts of the acetate and the propionate (1 g in France and 50 g in Finland) demonstrated that the propionate was more active than the acetate, and that it also caught more males than a blend of the two compounds.     

苯甲醛缩氨基硫脲Cu(I)、Zn(Ⅱ)配合物的直接电化学合成

用电化学金属阳极氧化法在非水溶剂中合成了苯甲醛缩氨基硫脲（ＨＬ）与Ｃｕ（Ｉ）、Ｚｎ（Ⅱ）配合物,通过元素分析、红外光谱、紫外光谱、磁矩、摩尔电导等对配合物进行了表征。     

1-(3,5-二氯 4-异噻唑甲酰基)3-芳基脲及1-(3,5-二甲硫基 4-异噻唑甲酰基)3-芳基脲的合成

结构新颖的含异噻唑杂环脲类化合物被合成，其结构经元素分析，^1H NMR和IR所证实，异噻唑甲酰胺与芳基异氰酸酯的反应速率受芳基异氰酸酯的取代基影响，吸电子基使反应速度加快表明反应为亲核加成。     

新显色剂二溴对甲基偶氮羧磺的合成及其与锶显色反应的研究

报道了一种新型二溴对甲基偶氮羧磺染料的合成方法,及其与锶在0 48mol/L盐酸介质中形成的稳定的蓝色络合物.其最大吸收波长位于620nm处,表观摩尔吸光系数为8 88×104L·mol-1·cm-1,锶量在0～0 25μg/25mL范围内符合比尔定律.该试剂与其他测定锶的试剂相比,具有灵敏度高、选择性好等优点.     

聚氯乙烯－吡啶树脂的合成及其催化性能

聚氯乙烯与吡啶在浓氢氧化钠存在下制备了聚氯乙烯－吡啶树脂，它可用作相转移催化剂，对于许多有机反应具有良好的催化效果．     

超声波辐射法合成对、间羧基苯氧乙酸

用超声波辐射法合成了羧基苯氧乙酸，并通过IR、^1HNMR、^13C NMR对所合成的化合物进行了结构表征．通过正交实验，探索出了超声波辐射法合成羧基苯氧乙酸类化合物的最佳合成条件，这种合成方法具有反应条件温和、操作简便以及产率较高等特点。