加速参考系中速度和力的变换

利用狭义相对论方法和MΦller变换得到了加速参考系和惯性参考系之间速度和力的变换关系。     

Construction of multivalent DNA vaccines forMycobacterium tuberculosis and its immunogenicity

The coding regions of Ag85B MPT-64, and ESAT-6 secreted proteins were cloned initially into the eukaryotic expression vector pJW4303, then transformed to E. coli Top 10 strain for plasmid DNA extraction and further analysis. Plasmids containing the right insertion were sequenced to confirm their identity. COS7 cells were transfected with a mixture containing serially diluted plasmid DNA encoding three secreted proteins and Lipofectin (Gibco). The supernatants and pellets prepared from various cell lines were run on SDS-PAGE gel and the expression of these proteins in COS7 cells were demonstrated by immunoblot using polyclonal or monoclonal antiserum of M.TBH37Rv. 21 days after first vaccination of C57BL-6 mice by all three recombinant eukaryotic expressing vectors, antibody titer for Ag85B reached 1∶3200. 21 days after second vaccination, the antibody titer reached 1∶102400. The highest antibody levels induced by multivalent vaccines after the second injection were equal to or even greater than the highest antibody levels of single DNA vaccine reported in literature after third injections. Antibody titer of MPT-64 was 1∶50 after the first injection and it reached 1∶200 after the second injection. No antigen-specific antibody against ESAT-6 was detected in sera harvested from immunized mice 21 days after both injections. Antigen-specific IFN-g level of Ag85B was 110 pg/mL while no antigen-specific IFN- g level of ESAT-6 and MPT-64 was detected even after third injections. To our knowledge, it is the first time that studies of polyvalent recombinant DNA vaccines against TB were carried out in C57BL-6 mice. Our results indicated that multiple DNA vaccines could be used to enhance protective responses against M.TB.     

Hajek定理的一种多维形式

文章对独立、同分布的线性秩统计量渐近正态分布的Hajck定理进行了推广,得到了k维秩线性统计量渐近正态性的结果。     

Mbius函数μ(n)及其关联

本文主要给出Mbius函数μ(n)的若干结论,同时还给出它与其他数论函数T(n)、S(n)、(n)之间的关联,并用多种不同的方法加以证明.     

新一代开放系统及互操作性研究

经历 2 0世纪 90年代的持续实践 ,采用“开放系统”的思想来集成大型的计算机系统已成为技术界不争的事实。然而 ,技术的发展使得传统的开放系统面临严峻的挑战 ,需要新的标准、技术来使开放系统体现高度的智能协作性及移动性。基于完善的开放系统的实际形成有赖于“互操作性”的实现这一原因 ,以互操作性为研究对象 ,以移动agent为研究工具 ,探讨了新一代开放系统实现机制以及未来发展的前景。     

两种数字生命的Swarm仿真研究

数字生命的概念是托马斯·雷最早在计算机上模拟实验提出的,以此为指导,介绍了复杂适应系统、Agent建模等理论知识,利用Swarm仿真平台构建了两种异类数字生命及共同生存的环境,模拟自然界生命体最基础的繁殖歼灭等生命现象,通过可视化窗口观察生命体个体及群体间的交互行为,得到结果的不可测性和突现性,实现了两种数字生命的Swarm仿真。     

基于Agent仿真的ATIS条件下路径选择行为研究

在复杂适应系统理论指导下,采用基于Agent的建模理论,对ATIS条件下出行者的路径选择行为从宏观、微观两个层面分别进行建模。按照建模结果,利用Repast平台建立了计算机仿真系统。在该仿真系统中对具有两条平行路径的路网上进行了仿真实验,实验结果表明ATIS系统对于出行者的出行规划有一定影响,而且ATIS的收益随着交通流量的增加有一定提高。研究结论为ATIS的应用提供了有益的参考。