某型号高速列车M车的振动舒适性分析

研究了如何在高速列车设计阶段预测机车振动舒适特性.首先采用ANSYS建立某型号高速列车M车的有限元模型,在MATLAB中采用频域法对功率谱密度进行处理;然后以轨道水平不平顺为例进行瞬态分析模拟出高速列车在运行时的整车响应,采集地板上某些节点加速度响应数据,进行相关处理后得出了M车对应的舒适度和平稳性指标.这种方法使理论设计阶段进行有效地评价高速列车在不同运行工况下的振动特性和旅客乘坐舒适性成为可能     

极坐标系下麦克斯韦方程的分裂时域有限差分方法

将直角坐标系下的分裂时域有限差分方法（S—FDTD）推广到极坐标系情形中,提出了极坐标系下,带有理想导体边界条件的麦克斯韦方程的分裂时域有限差分方法（PS—FDTD）,分析了此方法的相容性和截断误差,并通过对奇点的特殊处理给出了计算方法和步骤．数值算例验证了该方法的有效性．     

基于潜在语义分析的领域知识地图构建技术

信息过载现象普遍存在于产品设计过程中,而提升信息和知识检索的准确性是解决该问题的主要手段. 领域知识地图能够为知识检索引擎提供领域知识关联信息,以提升知识检索的准确性. 针对领域知识地图的构建,提出了一种半自动化的领域知识地图构建过程. 该过程采用领域专家定义领域特征集的方法来提升领域特征集的全面性和独立性,进一步采用潜在语义分析技术（LSA）消除领域特征集中存在的语义交叉. 通过分析领域知识相似度的分布,采用优先去除中距离的策略构建最终的知识地图. 最后给出数控领域知识地图的构建过程,证明了该方法的有效性.      

一种频域RS-LT级联码在短波通信中的应用研究

针对短波通信中同时存在误码和丢包的特点,提出了一种频域RS码与数字喷泉码串行级联的纠错纠删编码算法,并在FPGA芯片及短波电台终端上予以实现。频域RS码作为外码,LT码作为内码,使RS码和LT码互相促进,同时实现纠删和纠错,这是单独采用两种编码方法都无法达到的。仿真表明RS-LT级联编码可提高LT码译码成功概率。同时短波信道实测结果表明,编码模块的应用可有效提高短波电台正确接收概率。     

倾斜转弯导弹三回路鲁棒自动驾驶仪设计

针对倾斜转弯导弹,提出了最优/经典综合设计方法设计自动驾驶仪.该方法应用最优控制设计出俯仰/偏航混合通道三回路自动驾驶仪,设计中同时对开环系统的奇异值频域曲线进行约束,以保证系统具有一定的鲁棒性,获得的三回路自动驾驶仪结构简单,易于工程实现.仿真结果证实了其具有良好的跟踪性能和鲁棒性,也表明该自动驾驶仪能满足倾斜转弯导弹协调倾斜转弯的要求.     

一种基于动态服务规格的病态流控制方法

在区分服务网络确保转发(assured forwarding)服务中,提出一种基于动态服务规格(service profiles)的病态流控制机制。该机制在DS域的入口节点(ingress node)根据核心节点反馈的信息动态地调整病态流的当前服务规格和进入DS域的速率,达到控制病态流的目的。模拟实验表明,该机制可以有效地提高正常业务流的性能,控制由病态流引起的DS域内全局最大-最小不公平(global max-min unfairness)问题。     

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

The fraction of pyruvate dehydrogenase complex (PDC) in the active form is reduced by the activities of dedicated PD kinase isozymes (PDK1, PDK2, PDK3 and PDK4). Via binding to the inner lipoyl domain (L2) of the dihydrolipoyl acetyltransferase (E2 60mer), PDK rapidly access their E2-bound PD substrate. The E2-enhanced activity of the widely distributed PDK2 is limited by dissociation of ADP from its C-terminal catalytic domain, and this is further slowed by pyruvate binding to the N-terminal regulatory (R) domain. Via the reverse of the PDC reaction, NADH and acetyl-CoA reductively acetylate lipoyl group of L2, which binds to the R domain and stimulates PDK2 activity by speeding up ADP dissociation. Activation of PDC by synthetic PDK inhibitors binding at the pyruvate or lipoyl binding sites decreased damage during heart ischemia and lowered blood glucose in insulin-resistant animals. PDC activation also triggers apoptosis in cancer cells that selectively convert glucose to lactate. Received 25 August 2006; received after revision 20 November 2006; accepted 20 December 2006     

SET domain protein lysine methyltransferases: Structure, specificity and catalysis

Site- and state-specific lysine methylation of histones is catalyzed by a family of proteins that contain the evolutionarily conserved SET domain and plays a fundamental role in epigenetic regulation of gene activation and silencing in all eukaryotes. The recently determined three-dimensional structures of the SET domains from chromosomal proteins reveal that the core SET domain structure contains a two-domain architecture, consisting of a conserved anti-parallel β-barrel and a structurally variable insert that surround a unusual knot-like structure that comprises the enzyme active site. These structures of the SET domains, either in the free state or when bound to cofactor S-adenosyl-L-homocysteine and/or histone peptide, mimicking an enzyme/cofactor/substrate complex, further yield the structural insights into the molecular basis of the substrate specificity, methylation multiplicity and the catalytic mechanism of histone lysine methylation. Received 10 June 2006; accepted 22 August 2006     

Optimization of the cellular import of functionally active SH2-domain-interacting phosphopeptides

Phosphopeptides interacting with src homology 2 (SH2) domains can activate essential signaling enzymes in vitro. When delivered to cells, they may disrupt protein-protein interactions, thereby influencing intracellular signaling. We showed earlier that phosphopeptides corresponding to the inhibitory motif of Fcγ receptor IIb and a motif of the Grb2-associated binder 1 adaptor protein activate SH2-containing tyrosine phosphatase 2 in vitro. To study the ex vivo effects of these peptides, we have now compared different methods for peptide delivery: (i) permeabilization of the target cells and (ii) the use of cell-permeable vectors, which are potentially able to transport biologically active compounds into B cells. We found octanoyl-Arg₈ to be an optimal carrier for the delivery of phosphopeptides to the cells. With this strategy, the function of cell-permeable SHP-2-binding phosphopeptides was analyzed. These peptides modulated the protein phosphorylation in B cells in a dose- and time-dependent manner. Received 27 July 2006; received after revision 4 September 2006; accepted 18 September 2006     

地中海果蝇鸣声特征分析

利用计算机鸣声分析技术,对地中海果蝇鸣声的声学特征进行了全面分析,探讨了果蝇鸣声特征及其生物学意义,并将果蝇鸣声区分为3个部分．结果表明,地中海果蝇召唤歌为正弦波,IPI（两相邻脉冲的时间间隔）均值为2．9ms,基频约为366Hz;而其求爱歌由脉冲串组成,每个脉冲串大约持续0．1s,求爱歌的IPI均值为3．2ms,基频约为146Hz．此分析为果蝇鸣声的系统研究提供了基础数据．