丘脑-皮层动态功能连接特点和性别差异

利用丘脑-皮层连接的动态特性估计男性和女性丘脑-皮层功能连接的不同状态,并通过统计学方法分析性别对于动态丘脑-皮层功能连接模式的影响.结果表明:在男性和女性中各自发现了9个动态功能连接状态,且在9个状态中,男性的丘脑-皮层的功能连接显著高于女性的丘脑-皮层的功能连接,拓展了人们对于丘脑-皮层连接的理解,并且探讨了动态丘脑-皮层功能连接的性别差异.     

从认知语言学角度看时间隐喻的跨文化相似性

隐喻是人类借助具体概念理解抽象概念的一种手段和思维方式。在汉英两种语言中皆存在时间——空间隐喻、时间——金钱隐喻、时间——实体隐喻，这说明时间的隐喻性思维具有跨文化相似性，它在一定程度上为思维决定语言提供了例证。     

实验动物遗传工程——功能基因组时代的研究平台

本文就实验动物遗传工程在研究基因功能及其表达调控、阐明疾病发生机理、寻找药物治疗靶点等方面的技术突破做了综述.     

Research on Chinese Visible Human Project

" Visible Human Project (VHP)" was initiated by US National Library of Medicine in 1989, and in August 1991, the library signed a contract with Health Science Center of the University of Colorado to formally carry out the project. Accordingly, research team at the University of Colorado collected a structural data set of human body after obtaining successive sectional images. A digital image data set of a complete human male cadaver was acquired and made available for public use in November 1994, which aroused worldwide enthusiasm in this field, and remarkable social and economic benefit has been gained. Thereafter, some countries initiated their visible human project one after another. Korea started 5-year" Visible Korean Human (VKH)" project (Mar. 2000-Feb. 2005) in 2000, and the first data set derived from a patient with cerebroma was acquired in 2001. China began its project in 1999. The first data set of Chinese visible human was obtained at The Third Military Medical University in October 2002. Be     

Syntheses of oxysterol receptors‘(LXRs)ligands

The LXRs‘ and agonist,24S,25-epoxycholesterol 1,was synthesized stereoselectively(100%d.e.)in 56% overall yield from methyl hyodeoxycholanate 4 in 9 steps with des mosterol acetate 11 as the key intermediate and the modified Sharpless asymmetric dihydroxylation as the key step.The LXRα subtype selective agonist 5α,6α,24S,25-diepoxycholesterol 2 and the novel LXRs‘ ligand 5β,6β:24S,25-diepoxycholesterol 3 were also synthesized from 1.     

光子链图传播下Bhabha散射截面的严格计算

采用光子与电子（正电子）的最小电磁耦合模型，获得了光子链图传播子重整化的有限量。对其辐射修正作了相关的计算和讨论，从而得到了电子-正电子碰撞在链近似下的散射截面，并与最低阶的散射截面作了比较．     

Effects of niacin on nitric oxide synthase expression in rat lungs exposed to silica

The aim of this study was to evaluate the effects of niacin in diet on the expression of nitric oxide synthase (NOS) in rat lungs of the animal model of silicosis established by direct tracheal instillation of silica particles into rat lungs surgically. The niacin concentration in serum was analyzed by high performance liquid chromatography (HPLC). The expression of inducible nitric oxide synthase (iNOS) protein in paraffin-embedded lung sections was determined by streptavidin/peroxidase (SP) staining. Quantitative analysis by Image-Pro Plus was also performed on the expression of iNOS. The results showed that niacin concentration in serum of the niacin-treated rats was significantly higher than that in the control and silica-treated rats. After 7 days of silica instillation, iNOS integrated optical density (IOD) in rat lungs and total NOS and iNOS activities in bronchoalveolar lavage fluid (BALF) in silica-treated rats rose by 273420.75, 2.61 units/mL and 1.89 units/mL respectively, when compared with those in the control rats. Niacin treatment significantly reduced silica-induced iNOS IOD in rat lung tissues and total NOS and iNOS activities in BALF supernatant by 248292.35, 1.50 units/mL and 0.91 units/mL, respectively, as compared with those in silica-treated rats. Therefore, niacin can effectively attenuate the pathological expression of NOS in rat lung tissues induced by silica particles.     

移植法建立大鼠肝癌模型

用肿瘤肝脏移植的方法建立了大鼠肝癌模型，对该模型的特点及应用价值进行了探讨，从为该模型简单，实用，适合于基础及临床研究。     

Exploring the developmental potential of adult mammalian somatic cells

In the traditional ciews on developmental biology,the process of a mammal from a zygote to an adult individual follows continuous changes of space and time environments and is the result of different expressions of target genes.It has long been known that this process is irreversible and the terminal differentiated adult cells,such as cardiac myocytes andneurons,will not divide and differentiate.But recent reports on the two hottest fields—cloning medicine and stem cell biology doubted these concepts.This may lead to a further understanding of the potentiality of mammal development and may provide great chances for commercial andd clinical practice.     

Effect of the control proliferation of astrocyte on the formation of glial scars by antisenseGFAP retrovirus

Astrocytes play an important role in the formation of glial scars. In order to investigate the effect of inhibitingGFAP gene expression on normal, reactive astrocytes and on glial scar formation, the efficiency of the recombinant antisenseGFAP retrovirus (PLBskG) on the growth, cell cycle, morphology andGFAP gene expression of astrocytesin vitro and on the formation of glial scarsin vivo has been studied by cell growth curves, flow cytometry, immunocytochemistry,in situ hybridization, RT-PCR and Southern blot. The results confirm the recombinant retrovirus (PLBskG) produced growth suppression and G1 arrest of the normal and injured astrocytes. The infected cells become round or ellipoid. The cell processes become fine or retracted. The intensity of staining ofGFAP is reduced. Expression ofGFAP mRNA is down regulated. However, in the control experiment, no obvious effects on the morphology or synthesis ofGFAP on cultured normal and scratched astrocytes infected by primary retrovirus vector (PLXSN) have been observed. The supernatant of PLBskG has been injected into an injured site by microinjectionin vivo. The number and process lengths of GFAP positive cells are obviously reduced around the injured site. The formation of the glial scar is inhibited, showing that the recombinant antisenseGFAP retrovirus can effectively inhibit the growth andGFAP expression of normal and injured astrocytesin vitro and the formation of glial scarin vivo. It is suggested thatGFAP plays an important role in glial scar formation.