排序方式: 共有42条查询结果,搜索用时 375 毫秒
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Molecular mechanisms of desiccation tolerance in the resurrection glacial relic Haberlea rhodopensis
Tsanko S. Gechev Maria Benina Toshihiro Obata Takayuki Tohge Neerakkal Sujeeth Ivan Minkov Jacques Hille Mohamed-Ramzi Temanni Andrew S. Marriott Ed Bergström Jane Thomas-Oates Carla Antonio Bernd Mueller-Roeber Jos H. M. Schippers Alisdair R. Fernie Valentina Toneva 《Cellular and molecular life sciences : CMLS》2013,70(4):689-709
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Valentina Aprigliano 《Journal of forecasting》2020,39(8):1291-1304
This paper proposes a Bayesian vector autoregression (BVAR) model with the Kalman filter to forecast the Italian industrial production index in a pseudo real-time experiment. Minnesota priors are adopted as a general framework, but a different shrinkage pattern is imposed for both the VAR coefficients and the Kalman gain, depending on the informative contribution of each variable investigated at frequency level. Both a time-varying and a constant selection for the shrinkage are proposed. Overall, the new BVAR models significantly improve the forecasting performance in comparison with the more traditional versions based on standard Minnesota priors with a single shrinkage, equal for all the variables, and selected on the basis of some optimal criteria. Very promising results come out in terms of density forecasting as well. 相似文献
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Hennies HC Kornak U Zhang H Egerer J Zhang X Seifert W Kühnisch J Budde B Nätebus M Brancati F Wilcox WR Müller D Kaplan PB Rajab A Zampino G Fodale V Dallapiccola B Newman W Metcalfe K Clayton-Smith J Tassabehji M Steinmann B Barr FA Nürnberg P Wieacker P Mundlos S 《Nature genetics》2008,40(12):1410-1412
Gerodermia osteodysplastica is an autosomal recessive disorder characterized by wrinkly skin and osteoporosis. Here we demonstrate that gerodermia osteodysplastica is caused by loss-of-function mutations in SCYL1BP1, which is highly expressed in skin and osteoblasts. The protein localizes to the Golgi apparatus and interacts with Rab6, identifying SCYL1BP1 as a golgin. These results associate abnormalities of the secretory pathway with age-related changes in connective tissues. 相似文献
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Eduardo Suárez-Morales Alenka Goruppi Alessandra de Olazabal Valentina Tirelli 《Journal of Natural History》2017,51(31-32):1795-1834
Monstrilloid copepods collected during zooplankton surveys carried out over several years (2009–2016) in the Gulf of Trieste, northern Adriatic Sea, were examined. A total of seven species were found, of which six are undescribed, five of Cymbasoma and one of Monstrilla. These new species are described, illustrated and compared herein with its known congeners. Two of them are related to the C. rigidum species complex. One of these species is described based on both the male and the female; sexes were linked by identical details of the cephalic structure and the antennulary armature. Two previous reports of females attributed to C. tumorifrons from the Mediterranean relate to specimens that in fact belong to a new species, C. mediterranea. The most abundant species was M. grandis, which had a remarkable aggregation around the Trieste harbour in 2015. Male and female specimens of this assumedly widespread species were examined and the observed intra-specific morphological variability is reported and compared with previous illustrated reports; this nominal species probably this nominal species, probably represents a species complex. The addition of the new species here described brings the number of nominal species in the Mediterranean-Black Sea region to 26.
www.zoobank.org/urn:lsid:zoobank.org:pub:3D4B38E4-CCCD-4BD6-AC57-B59343A865F7 相似文献
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Stouffer AL Acharya R Salom D Levine AS Di Costanzo L Soto CS Tereshko V Nanda V Stayrook S DeGrado WF 《Nature》2008,451(7178):596-599
The M2 protein from influenza A virus is a pH-activated proton channel that mediates acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90% (ref. 1). Here we describe the crystal structure of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of the channel-blocking drug amantadine. pH-dependent structural changes occur near a set of conserved His and Trp residues that are involved in proton gating. The drug-binding site is lined by residues that are mutated in amantadine-resistant viruses. Binding of amantadine physically occludes the pore, and might also perturb the pK(a) of the critical His residue. The structure provides a starting point for solving the problem of resistance to M2-channel blockers. 相似文献
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The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease. 相似文献