排序方式: 共有118条查询结果,搜索用时 31 毫秒
101.
Federica Corallini Paola Secchiero Antonio Paolo Beltrami Daniela Cesselli Elisa Puppato Roberto Ferrari Carlo Alberto Beltrami Giorgio Zauli 《Cellular and molecular life sciences : CMLS》2010,67(8):1307-1314
The number of circulating mesenchymal stem cells (MSC), analyzed after acute myocardial infarction (AMI), was lower in AMI
patients who developed heart failure (HF) in the follow-up. Conversely, the circulating levels of tumor necrosis factor (TNF)-α,
and osteoprotegerin (OPG) were higher in AMI patients who developed HF with respect to the patients who did not develop HF.
In vitro exposure to TNF-α enhanced the migration of MSC in response to TNF-related apoptosis-inducing ligand (TRAIL) and
significantly increased the release of OPG by endothelial cells. On the contrary, OPG dose-dependently neutralized the in
vitro pro-migratory activity of TRAIL. Thus, TNF-α exhibits opposite effects on MSC migration driven by TRAIL: it is capable
of potentiating MSC migration as well as of inhibiting MSC migration as an indirect consequence of OPG induction, which might
result in a suboptimal recruitment of circulating MSC after AMI in those patients who develop HF in the follow-up. 相似文献
102.
Ioannidis JP Gwinn M Little J Higgins JP Bernstein JL Boffetta P Bondy M Bray MS Brenchley PE Buffler PA Casas JP Chokkalingam A Danesh J Smith GD Dolan S Duncan R Gruis NA Hartge P Hashibe M Hunter DJ Jarvelin MR Malmer B Maraganore DM Newton-Bishop JA O'Brien TR Petersen G Riboli E Salanti G Seminara D Smeeth L Taioli E Timpson N Uitterlinden AG Vineis P Wareham N Winn DM Zimmern R Khoury MJ;Human Genome Epidemiology Network the Network of Investigator Networks 《Nature genetics》2006,38(1):3-5
Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews. 相似文献
103.
Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract 总被引:1,自引:0,他引:1
Zara F Biancheri R Bruno C Bordo L Assereto S Gazzerro E Sotgia F Wang XB Gianotti S Stringara S Pedemonte M Uziel G Rossi A Schenone A Tortori-Donati P van der Knaap MS Lisanti MP Minetti C 《Nature genetics》2006,38(10):1111-1113
We describe a new autosomal recessive white matter disorder ('hypomyelination and congenital cataract') characterized by hypomyelination of the central and peripheral nervous system, progressive neurological impairment and congenital cataract. We identified mutations in five affected families, resulting in a deficiency of hyccin, a newly identified 521-amino acid membrane protein. Our study highlights the essential role of hyccin in central and peripheral myelination. 相似文献
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Nugent PE Sullivan M Cenko SB Thomas RC Kasen D Howell DA Bersier D Bloom JS Kulkarni SR Kandrashoff MT Filippenko AV Silverman JM Marcy GW Howard AW Isaacson HT Maguire K Suzuki N Tarlton JE Pan YC Bildsten L Fulton BJ Parrent JT Sand D Podsiadlowski P Bianco FB Dilday B Graham ML Lyman J James P Kasliwal MM Law NM Quimby RM Hook IM Walker ES Mazzali P Pian E Ofek EO Gal-Yam A Poznanski D 《Nature》2011,480(7377):344-347
Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after accreting matter in a binary system, but the secondary body could be anything from a main-sequence star to a red giant, or even another white dwarf. This uncertainty stems from the fact that no recent type Ia supernova has been discovered close enough to Earth to detect the stars before explosion. Here we report early observations of supernova SN 2011fe in the galaxy M101 at a distance from Earth of 6.4 megaparsecs. We find that the exploding star was probably a carbon-oxygen white dwarf, and from the lack of an early shock we conclude that the companion was probably a main-sequence star. Early spectroscopy shows high-velocity oxygen that slows rapidly, on a timescale of hours, and extensive mixing of newly synthesized intermediate-mass elements in the outermost layers of the supernova. A companion paper uses pre-explosion images to rule out luminous red giants and most helium stars as companions to the progenitor. 相似文献
109.
Paolo Palmieri 《Studies in history and philosophy of science》2005,36(2):223-240
Still today it remains unclear whether Galileo ever climbed the leaning tower of Pisa in order to drop bodies from its top. Some believe that he established the principle of equal speeds for falling bodies by means of an ingenious thought experiment. However, the reconstruction of that thought experiment circulating in the philosophical literature is no more than a cartoon. In this paper I will tell the story of the thought processes behind the cartoon. 相似文献
110.
PML targeting eradicates quiescent leukaemia-initiating cells 总被引:1,自引:0,他引:1
Ito K Bernardi R Morotti A Matsuoka S Saglio G Ikeda Y Rosenblatt J Avigan DE Teruya-Feldstein J Pandolfi PP 《Nature》2008,453(7198):1072-1078
The existence of a small population of 'cancer-initiating cells' responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia-initiating cells, particularly those that are in a quiescent state, are thought to be resistant to chemotherapy and targeted therapies, resulting in disease relapse. Chronic myeloid leukaemia is a paradigmatic haematopoietic stem cell disease in which the leukaemia-initiating-cell pool is not eradicated by current therapy, leading to disease relapse on drug discontinuation. Here we define the critical role of the promyelocytic leukaemia protein (PML) tumour suppressor in haematopoietic stem cell maintenance, and present a new therapeutic approach for targeting quiescent leukaemia-initiating cells and possibly cancer-initiating cells by pharmacological inhibition of PML. 相似文献