Differentiation of the asteroid Ceres as revealed by its shape

The accretion of bodies in the asteroid belt was halted nearly 4.6 billion years ago by the gravitational influence of the newly formed giant planet Jupiter. The asteroid belt therefore preserves a record of both this earliest epoch of Solar System formation and variation of conditions within the solar nebula. Spectral features in reflected sunlight indicate that some asteroids have experienced sufficient thermal evolution to differentiate into layered structures. The second most massive asteroid--4 Vesta--has differentiated to a crust, mantle and core. 1 Ceres, the largest and most massive asteroid, has in contrast been presumed to be homogeneous, in part because of its low density, low albedo and relatively featureless visible reflectance spectrum, similar to carbonaceous meteorites that have suffered minimal thermal processing. Here we show that Ceres has a shape and smoothness indicative of a gravitationally relaxed object. Its shape is significantly less flattened than that expected for a homogeneous object, but is consistent with a central mass concentration indicative of differentiation. Possible interior configurations include water-ice-rich mantles over a rocky core.     

Single mimivirus particles intercepted and imaged with an X-ray laser

X-ray lasers offer new capabilities in understanding the structure of biological systems, complex materials and matter under extreme conditions. Very short and extremely bright, coherent X-ray pulses can be used to outrun key damage processes and obtain a single diffraction pattern from a large macromolecule, a virus or a cell before the sample explodes and turns into plasma. The continuous diffraction pattern of non-crystalline objects permits oversampling and direct phase retrieval. Here we show that high-quality diffraction data can be obtained with a single X-ray pulse from a non-crystalline biological sample, a single mimivirus particle, which was injected into the pulsed beam of a hard-X-ray free-electron laser, the Linac Coherent Light Source. Calculations indicate that the energy deposited into the virus by the pulse heated the particle to over 100,000?K after the pulse had left the sample. The reconstructed exit wavefront (image) yielded 32-nm full-period resolution in a single exposure and showed no measurable damage. The reconstruction indicates inhomogeneous arrangement of dense material inside the virion. We expect that significantly higher resolutions will be achieved in such experiments with shorter and brighter photon pulses focused to a smaller area. The resolution in such experiments can be further extended for samples available in multiple identical copies.     

板块构造启动的时间和机制:理论和经验探索

板块构造是指位于对流地幔圈层之上的岩石圈的水平运动,主要由岩石圈在俯冲带的下沉作用所致.板块构造是一个典型的、非平衡复杂体系的自组系统(selforganizing,far from equilibrium complex system,SOFFECS),其驱动力主要来自热边界层(岩石圈)的反向浮力,同时又受控于变形岩石圈与下覆粘性软流圈地幔的耗散作用.在太阳系内侧5个硅酸质行星中,板块构造仅发育于地球,这表明板块构造是硅酸质行星不太常见的一种热散逸方式.目前还不清楚这种构造活动和热散逸方式在地球上是从何时开始的.所有的硅酸质行星在形成初期可能都经历过一次短暂的岩浆海阶段.行星固结后,静止盖层模式是行星冷却的共同途径,即行星表面形成了一个不易活动的固化盖层,此时内部的热量只能通过拆沉作用、热点火山作用和岩浆浅部侵位等方式进行逃逸.由于地球早期温度较高,通过减压熔融形成的岩石圈结构不同于现代岩石圈,即地球早期岩石圈由厚的洋壳和薄的岩石圈地幔构成.这种岩石圈要产生反向浮力需要非常长的时间,因此地球早期即便有板块构造存在,其规模也比较零星.只有当地球冷却到一定程度,扩张中脊下部减压熔融形成薄的洋壳且大洋岩石圈只需几十个百万年就可以产生反向浮力时,才能形成与现今风格相似的、可持续性的板块构造.板块构造启动时间的认识最终取决于人们对相关地质记录(事件)的研究成果.板块构造的判别依据包括蛇绿岩、蓝片岩、超高压变质带、榴辉岩、被动大陆边缘、转换断层、指示克拉通陆块移动轨迹的古地磁研究以及岩浆岩地球化学和同位素构造判别等等.对地质记录的解释必须综合各方面的信息.本人认为现存的地质事件记录了地球构造随时间演化的过程,即太古代时期构造和岩浆活动剧烈,大约在1.9 Ga时开始出现近似的板块构造,在新元古代才开始出现与现代相似的、可持续的、具有深俯冲和板片拖曳特性的板块构造.     

Climate change and the resurgence of malaria in the East African highlands

The public health and economic consequences of Plasmodium falciparum malaria are once again regarded as priorities for global development. There has been much speculation on whether anthropogenic climate change is exacerbating the malaria problem, especially in areas of high altitude where P. falciparum transmission is limited by low temperature. The International Panel on Climate Change has concluded that there is likely to be a net extension in the distribution of malaria and an increase in incidence within this range. We investigated long-term meteorological trends in four high-altitude sites in East Africa, where increases in malaria have been reported in the past two decades. Here we show that temperature, rainfall, vapour pressure and the number of months suitable for P. falciparum transmission have not changed significantly during the past century or during the period of reported malaria resurgence. A high degree of temporal and spatial variation in the climate of East Africa suggests further that claimed associations between local malaria resurgences and regional changes in climate are overly simplistic.     

Mechanism of urea nitrogen binding by proposed oxidized starch gastrointestinal absorbents.

By use of 14-C label it was demonstrated that apparent binding of urea N to polyaldehyde starch was probably preceeded by hydrolysis to ammonium ion. Thus direct urea binding was not the mechanism through which ingested polyaldehyde starch might increase fecal N excretion in uremic patients.     

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

Type 1 diabetes is an autoimmune disease influenced by multiple genetic loci. Although more than 20 insulin-dependent diabetes (Idd) loci have been implicated in the nonobese diabetic (NOD) mouse model, few causal gene variants have been identified. Here we show that RNA interference (RNAi) can be used to probe candidate genes in this disease model. Slc11a1 encodes a phagosomal ion transporter, Nramp1, that affects resistance to intracellular pathogens and influences antigen presentation. This gene is the strongest candidate among the 42 genes in the Idd5.2 region; a naturally occurring mutation in the protective Idd5.2 haplotype results in loss of function of the Nramp1 protein. Using lentiviral transgenesis, we generated NOD mice in which Slc11a1 is silenced by RNAi. Silencing reduced the frequency of type 1 diabetes, mimicking the protective Idd5.2 region. Our results demonstrate a role for Slc11a1 in modifying susceptibility to type 1 diabetes and illustrate that RNAi can be used to study causal genes in a mammalian model organism.     

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

We characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed melanomas had markedly more ultraviolet (UV)-like C>T somatic mutations compared to sun-shielded acral, mucosal and uveal melanomas. Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS. Notably, we identified a recurrent UV-signature, an activating mutation in RAC1 in 9.2% of sun-exposed melanomas. This activating mutation, the third most frequent in our cohort of sun-exposed melanoma after those of BRAF and NRAS, changes Pro29 to serine (RAC1(P29S)) in the highly conserved switch I domain. Crystal structures, and biochemical and functional studies of RAC1(P29S) showed that the alteration releases the conformational restraint conferred by the conserved proline, causes an increased binding of the protein to downstream effectors, and promotes melanocyte proliferation and migration. These findings raise the possibility that pharmacological inhibition of downstream effectors of RAC1 signaling could be of therapeutic benefit.