排序方式: 共有14条查询结果,搜索用时 156 毫秒
11.
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers 总被引:21,自引:0,他引:21
12.
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis 总被引:27,自引:0,他引:27
Papanikolaou G Samuels ME Ludwig EH MacDonald ML Franchini PL Dubé MP Andres L MacFarlane J Sakellaropoulos N Politou M Nemeth E Thompson J Risler JK Zaborowska C Babakaiff R Radomski CC Pape TD Davidas O Christakis J Brissot P Lockitch G Ganz T Hayden MR Goldberg YP 《Nature genetics》2004,36(1):77-82
13.
Zou P Pinotsis N Lange S Song YH Popov A Mavridis I Mayans OM Gautel M Wilmanns M 《Nature》2006,439(7073):229-233
The Z-disk of striated and cardiac muscle sarcomeres is one of the most densely packed cellular structures in eukaryotic cells. It provides the architectural framework for assembling and anchoring the largest known muscle filament systems by an extensive network of protein-protein interactions, requiring an extraordinary level of mechanical stability. Here we show, using X-ray crystallography, how the amino terminus of the longest filament component, the giant muscle protein titin, is assembled into an antiparallel (2:1) sandwich complex by the Z-disk ligand telethonin. The pseudosymmetric structure of telethonin mediates a unique palindromic arrangement of two titin filaments, a type of molecular assembly previously found only in protein-DNA complexes. We have confirmed its unique architecture in vivo by protein complementation assays, and in vitro by experiments using fluorescence resonance energy transfer. The model proposed may provide a molecular paradigm of how major sarcomeric filaments are crosslinked, anchored and aligned within complex cytoskeletal networks. 相似文献
14.
Woyke T Teeling H Ivanova NN Huntemann M Richter M Gloeckner FO Boffelli D Anderson IJ Barry KW Shapiro HJ Szeto E Kyrpides NC Mussmann M Amann R Bergin C Ruehland C Rubin EM Dubilier N 《Nature》2006,443(7114):950-955
Symbioses between bacteria and eukaryotes are ubiquitous, yet our understanding of the interactions driving these associations is hampered by our inability to cultivate most host-associated microbes. Here we use a metagenomic approach to describe four co-occurring symbionts from the marine oligochaete Olavius algarvensis, a worm lacking a mouth, gut and nephridia. Shotgun sequencing and metabolic pathway reconstruction revealed that the symbionts are sulphur-oxidizing and sulphate-reducing bacteria, all of which are capable of carbon fixation, thus providing the host with multiple sources of nutrition. Molecular evidence for the uptake and recycling of worm waste products by the symbionts suggests how the worm could eliminate its excretory system, an adaptation unique among annelid worms. We propose a model that describes how the versatile metabolism within this symbiotic consortium provides the host with an optimal energy supply as it shuttles between the upper oxic and lower anoxic coastal sediments that it inhabits. 相似文献