Crown ethers which influence cardiac and respiratory muscle contractility

Guinea-pig tracheal smooth muscle and heart muscle demonstrated a variety of in vitro positive and negative inotropic responses to concentrations of crown ethers in the nmole/1 to mumole/1 range. It is suggested that these ionophoretic compounds have potential as therapeutic agents.     

Homing behaviour of axons in the embryonic vertebrate brain

In embryonic nervous systems, growing axons must often travel long distances through diverse extracellular terrains to reach their postsynaptic partners. In most embryos, axons grow to their appropriate targets along particular tracts or nerves, as though they were following guidance cues confined to specific pathways. For example, in all vertebrates, axons from the retina invariably grow to the tectum along the well-defined optic tract. Yet, transplant experiments demonstrate that retinal axons make tectal projections even though they enter the brain at locations which are distinctly off the optic tract. Only recently has it become possible to label discreet growing projections in the embryonic vertebrate brain. Thus, it is not yet known whether displaced retinal axons grow directly towards the tectum or find it accidently, through random extension. To resolve this question, pioneering axons from normal and transplanted eyes in embryonic Xenopus were labelled using a short-survival horseradish peroxidase (HRP) method, and their orientation during growth was quantitatively assessed. The finding that the ectopic fibres head towards their distant targets implies that guidance cues are not restricted to specific pathways but are distributed throughout the embryonic brain. The significance of this result is discussed with respect to the ontogeny and evolution of the visual pathway.     

Naltrexone influence on hibernation

Summary In the garden dormouse, opiate receptor blockade by naltrexone decreased the score for sleeping behaviour during hibernation at 24.00 h, indicative of a possible involvement of endorphins in the control of hibernation.Acknowledgment. The author wishes to thank Dr B. Bondy, Dr J. Wissmann and Mr A. Wünsch for helpful assistance.     

The real exchange rate,fiscal policy and the role of wealth an analysis of equilibrium in a monetary union

This paper is concerned with the adjustment processes within a potential European monetary union and looks in particular at permanent asymmetric shocks that require an adjustment in a country's (or region's) real exchange rate. We first consider some of the implications of EMU and the question of asymmetries within the European economy. The presence of asymmetries and, in particular, different institutional structures in labour markets is a potential source of tension within a union and it could make a union difficult to sustain. However, automatic adjustment processes will be at work within a monetary union as a result of changes in relative price levels, which change real exchange rates, and also as a result of changes in wealth stocks. We use our econometric world model, NIGEM, to investigate the effects of asymmetric fiscal expansions and real exchange rate misalignments within a monetary union. In order to quantify the effects of such permanent asymmetric shocks we have introduced wealth into our model. Our simulations suggest that the principal impact of the fiscal expansion on both output and the price level will occur within the country in which the expansion occurs. Short-term gains are crowded out in the medium term, and while monetary union reduces crowding out in the short term, it increases the rate at which crowding out occurs thereafter. We also analyse the effects of real exchange rate misalignments and find that the processes of adjustment may be very protracted. This could cause strain on the union as adjustment costs are shared unequally.     

Daily melatonin injections inhibit short-day-induced testicular regression in hamsters

Summary Daily injections of melatonin were found to retard testicular regression in hamsters exposed to LD 10:14, if the injections occurred in the morning (i.e., 0.5 h after lights on), but not if they occurred in the afternoon (i.e., 6 h after lights on). These results indicate that appropriately timed injections of melatonin can at least partially block the inhibitory effects of short days on gonadal activity in the photoperiodic hamster.We wish to thank Susan Losee and Susan Stice for excellent technical assistance and Gary Ellis for his comments. This investigation was supported by NIH grants HD-09885, HD 12622 and Research Career Development Award HD-00249 (F. W. T.) from the National Institute of Child Health and Human Development.