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排序方式: 共有147条查询结果,搜索用时 15 毫秒
81.
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels 总被引:1,自引:1,他引:0
Alessia Peserico Fulvio Chiacchiera Valentina Grossi Antonio Matrone Dominga Latorre Marta Simonatto Aurora Fusella James G. Ryall Lydia W. S. Finley Marcia C. Haigis Gaetano Villani Pier Lorenzo Puri Vittorio Sartorelli Cristiano Simone 《Cellular and molecular life sciences : CMLS》2013,70(11):2015-2029
82.
83.
Antonio Di Tizzano 《Cellular and molecular life sciences : CMLS》1946,2(3):86-99
Summary After a short reference to the fundamental principles of the oxidation-reduction potential and the meaning of the symbolr
H introduced byClark, the author proceeds to set out, among the numerous applications which this important notion has found in various scientific fields, those found in Bacteriology and Hygiene.As regards Bacteriology, the oxidation-reduction potential of the sterile culture media and of various aerobic and anaerobic micro-organisms has been investigated in connection with their growth. The oxidation-reduction potential has proved to be a very good means of classification and identification of the various bacterial strains.Moreover, although the studies performed are not numerous the said oxidation-reduction potential has also been shown to have a great importance in the determination of the immunisation processes of the organism and in its serological behaviour.The oxidation-reduction potential, furthermore, has found very large applications in the field of alimentation, from the problem of fermentations, such as the alcoholic fermentation and the bread fermentation, to the distinction between raw and boiled milk by means ofSchardinger's reaction.In the future, the possibilities for application and development of the oxidation-reduction potential appear to be even more considerable. 相似文献
84.
This paper deals with the economic interpretation of the unobserved components model in the light of the apparent problem posed by previous work in that several practiced methodologies seem to lead to very different models of certain economic variables. A detailed empirical analysis is carried out to show how the failure in obtaining quasi-orthogonal components can seriously bias the interpretation of some decomposition procedures. Finally, the forecasting performance (in both the short and long run) of these decomposition models is analyzed in comparison with other alternatives. 相似文献
85.
Roberto Rodes Antonio Caballero Jesper Bevensee Jensen Timothy Braidwood Gibbon Neil Guerrero Gonzalez Idelfonso Tafur Monroy 《清华大学学报》2010,15(2):169-173
We theoretically analyze the channel capacity of a 5th-order Gaussian pulse-based ultra-wideband (UWB) system and experimentally demonstrate 2 Gbit/s UWB-over-fiber transmission systems incorporating wireless transmission. Both electrical and photonic UWB pulse generation methods are employed and its performance is compared. By utilizing optimum UWB pulse design and employing a digital signal processing (DSP) receiver, a bit-error-rate above the forward error correction (FEC) limit for 8 meters of wireless ... 相似文献
86.
87.
Zielinski CE Mele F Aschenbrenner D Jarrossay D Ronchi F Gattorno M Monticelli S Lanzavecchia A Sallusto F 《Nature》2012,484(7395):514-518
IL-17-producing CD4+ T helper cells (TH17) have been extensively investigated in mouse models of autoimmunity. However, the requirements for differentiation and the properties of pathogen-induced human TH17 cells remain poorly defined. Using an approach that combines the in vitro priming of naive T cells with the ex vivo analysis of memory T cells, we describe here two types of human TH17 cells with distinct effector function and differentiation requirements. Candida albicans-specific TH17 cells produced IL-17 and IFN-γ, but no IL-10, whereas Staphylococcus aureus-specific TH17 cells produced IL-17 and could produce IL-10 upon restimulation. IL-6, IL-23 and IL-1β contributed to TH17 differentiation induced by both pathogens, but IL-1β was essential in C. albicans-induced TH17 differentiation to counteract the inhibitory activity of IL-12 and to prime IL-17/IFN-γ double-producing cells. In addition, IL-1β inhibited IL-10 production in differentiating and in memory TH17 cells, whereas blockade of IL-1β in vivo led to increased IL-10 production by memory TH17 cells. We also show that, after restimulation, TH17 cells transiently downregulated IL-17 production through a mechanism that involved IL-2-induced activation of STAT5 and decreased expression of ROR-γt. Taken together these findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase. 相似文献
88.
Mackay TF Richards S Stone EA Barbadilla A Ayroles JF Zhu D Casillas S Han Y Magwire MM Cridland JM Richardson MF Anholt RR Barrón M Bess C Blankenburg KP Carbone MA Castellano D Chaboub L Duncan L Harris Z Javaid M Jayaseelan JC Jhangiani SN Jordan KW Lara F Lawrence F Lee SL Librado P Linheiro RS Lyman RF Mackey AJ Munidasa M Muzny DM Nazareth L Newsham I Perales L Pu LL Qu C Ràmia M Reid JG Rollmann SM Rozas J Saada N Turlapati L Worley KC Wu YQ Yamamoto A Zhu Y Bergman CM Thornton KR 《Nature》2012,482(7384):173-178
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics. 相似文献
89.
90.
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders 总被引:10,自引:0,他引:10
Jones B Jones EL Bonney SA Patel HN Mensenkamp AR Eichenbaum-Voline S Rudling M Myrdal U Annesi G Naik S Meadows N Quattrone A Islam SA Naoumova RP Angelin B Infante R Levy E Roy CC Freemont PS Scott J Shoulders CC 《Nature genetics》2003,34(1):29-31
Dietary fat is an important source of nutrition. Here we identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption. The Sar1 family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles. Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell. 相似文献