时间分数阶Sharma-Tasso-Olver方程和Zakharov方程组的新精确解

利用推广的Kudryashov方法, 借助分数阶行波变换和一致分数阶导数, 给出非线性广义时间分数阶Sharma Tasso Olver方程和Zakharov方程组的若干双曲函数形式的精确解.     

On the origins and foundations of Laplacian determinism

In this paper I examine the foundations of Laplace’s famous statement of determinism in 1814, and argue that rather than derived from his mechanics, this statement is based on general philosophical principles, namely the principle of sufficient reason and the law of continuity. It is usually supposed that Laplace’s statement is based on the fact that each system in classical mechanics has an equation of motion which has a unique solution. But Laplace never proved this result, and in fact he could not have proven it, since it depends on a theorem about uniqueness of solutions to differential equations that was only developed later on. I show that the idea that is at the basis of Laplace’s determinism was in fact widespread in enlightenment France, and is ultimately based on a re-interpretation of Leibnizian metaphysics, specifically the principle of sufficient reason and the law of continuity. Since the law of continuity also lies at the basis of the application of differential calculus in physics, one can say that Laplace’s determinism and the idea that systems in physics can be described by differential equations with unique solutions have a common foundation.     

地方新建本科高校办学定位分析及应对策略

20世纪末以来，中国高等教育管理体制改革催生了一大批地方新建本科高校。这些高校是中国高等教育普及化的实践者，却存在办学层次、人才培养和服务面向定位不准确的问题。针对办学定位不准的原因分析，必须调整、优化地方新建本科高校的内部和外部环境，才能保证这些高校的可持续发展。     

涠洲岛两种石珊瑚在高温胁迫下共生细菌群落结构变化特征

石珊瑚中的块状珊瑚与枝状珊瑚对全球气候变暖胁迫的耐受能力明显不同,但其机制仍不清楚。本研究选择北部湾涠洲岛的一种属于块状珊瑚的海孔角蜂巢珊瑚(Favites halicora)和一种属于枝状珊瑚的浪花鹿角珊瑚(Acropora cytherea)为研究对象,通过室内模拟实验,分析高温胁迫下(26～34℃) 2种珊瑚共生细菌群落的响应特征。结果表明:共生细菌多样性具有差异性,A.cytherea共生细菌的多样性随着温度上升变化显著,Shannon指数由2.20变为4.05,而F.halicora变化幅度较小,在2.69～3.19波动;主导细菌存在差异,在门水平上,F.halicora占主导地位的共生细菌为Proteobacteria (29%～73%)、Cyanobacteria (7%～63%)和Bacteroidetes(3%～13%),而A. cytherea为Proteobacteria (49%～90%)、Cyanobacteria (1%～16%)、Bacteroidetes (3%～16%)、Firmicutes (1%～6%)和一个未分类的细菌门unclassified_k_norank(0.6%～21.0%);升温胁迫时,主导细菌的丰度变化存在差别,Bacteroidetes在F.halicora中显著降低,而在A.cytherea中显著升高,unclassified_k_norank在A.cytherea中也显著升高;随着温度升高,2种珊瑚共生细菌的变化趋势一致,但珊瑚中出现潜在致病菌Vibrio的温度不同,F.halicora在34℃胁迫时出现,A.cytherea在30℃和34℃胁迫时均出现。根据上述结果推测,珊瑚共生细菌的差异性可能是导致块状珊瑚比枝状珊瑚更耐受高温的重要原因。     

遥感与水动力模型相结合的宽大潮滩历史地形反演

潮滩作为陆海交互区,面积宽广,测量困难,历史地形资料缺失,已经严重影响到潮滩的开发利用。以辐射沙脊群潮滩为实验区,利用1987年前后的TM、MSS影像提取不同潮情下的系列水边线,运用Mike21水动力模型模拟遥感图像对应时刻下的瞬时海面高度,为水边线赋值,进而通过地形反复迭代得到数字高程模型。结果表明,在辐射沙脊群潮滩区,水边线法获取的地形结果与海图上测点的相关性较高,决定系数R~2达0.864,绝对平均误差0.37 m,均方根误差0.41 m,地形结果可用于进一步的潮滩地貌演变分析。     

烃族组成对柴油储存安定性影响研究

针对柴油储存过程中质量衰变问题，利用典型柴油样品，开展烃化合物对中国成品柴油储存安定性影响规律研究。烃组成分析测定结果表明，柴油中总芳烃和链烷烃之间存在很强的相关性（相关系数为0.90）。综合采用相关分析、逐步线性回归等方法，建立了安定性指标与烃组成的关联模型，拟合验证表明模型可靠，可以直接用于柴油储存安定性预测；研究确定了柴油储存安定性的主要影响物质，按照对储存安定性指标影响的严重程度将烃类物质分为三个等级，其中苊烯和三环芳烃对柴油质量衰变影响最大，链烷烃对十六烷值和热值影响最大。     

互联网金融环境下智能投顾对于投资行为的影响

基于国内知名网贷平台的数据，采用固定效应模型和双重差分分析方法，研究了智能投顾的使用对于投资者的投资金额和风险偏好的影响。实证结果表明，智能投顾的使用会减少投资者的单笔投资金额，增加投资者的总投资金额，并使得投资者的风险偏好趋于保守。研究结果丰富了智能投顾和行为金融学的研究内容，加深了智能投顾企业对于投资者行为的理解，使其可以更好地设计和完善相关服务。     

The stoichiometry of peptide-heparan sulfate binding as a determinant of uptake efficiency of cell-penetrating peptides

Binding to negatively charged heparan sulfates (HS) at the cell surface is considered the first step in the internalization of cationic cell-penetrating peptides (CPPs). However, little is known about the relation of the characteristics of the HS-CPP interaction such as affinity, stoichiometry, and clustering with uptake. In this study, we investigated a collection of mutants of a cyclic CPP derived from human lactoferrin with respect to HS binding and uptake. The thermodynamic parameters of HS binding were determined by isothermal titration calorimetry, clustering of HS was investigated by dynamic light scattering, and cellular uptake by flow cytometry and confocal microscopy. Whereas mutations of non-arginine amino acids that are conserved across lactoferrins of different mammalia only had a minor effect on uptake efficiency, changes in the number of arginine residues influenced the uptake significantly. In general, introduction of arginine residues and cyclization improved the HS affinity and the ability to cluster HS. In particular, there was a strong negative correlation between stoichiometry and uptake, indicating that crosslinking of HS is the driving force for the uptake of arginine-rich CPPs. Using glycan microarrays presenting a collection of synthetic HS, we show that a minimal chain length of HS is required for peptide binding.     

论专门用途英语与体育英语教学的融合——以福建体育职业技术学院为例

专门用途英语（ESP）教学理念对体育英语教学有现实指导意义,二者之间存在逻辑关联。以福建体育职业技术学院调查为例,指出我国高职院校体育英语教学现状不容乐观。针对问题,从教学目标、教学素材、教学关系、教学平台以及教学评价等维度,提出强化专门用途英语与体育英语教学融合的若干建议。     

Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen the inflammatory response and to mediate the endotoxin-induced endocytic retrieval of Toll-like receptor 4 (TLR4) in human macrophages. Depletion of CDC50A, the β-subunit that is crucial for the activity of multiple P4-ATPases, resulted in endotoxin-induced hypersecretion of proinflammatory cytokines, enhanced MAP kinase signaling and constitutive NF-κB activation. In addition, CDC50A-depleted THP-1 macrophages displayed reduced tolerance to endotoxin. Moreover, endotoxin-induced internalization of TLR4 was strongly reduced and coincided with impaired endosomal MyD88-independent signaling. The phenotype of CDC50A-depleted cells was also induced by separate knockdown of two P4-ATPases, namely ATP8B1 and ATP11A. We conclude that lipid flippases are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4.